Abstract
Phagocytes play critical roles in the maintenance of organismal homeostasis and immunity. Central to their role is their ability to take up and process exogenous material via the related processes of phagocytosis and macropinocytosis. The mechanisms and functions underlying macropinocytosis have remained severely understudied relative to phagocytosis. In recent years, however, there has been a renaissance in macropinocytosis research. Phagocytes can engage in various forms of macropinocytosis including an “induced” form and a “constitutive” form. This chapter, however, will focus on constitutive macropinocytosis and its role in the maintenance of immunity. Functions previously attributed to macropinocytosis, including antigen presentation and immune surveillance, will be revisited in light of recent revelations and emerging concepts will be highlighted.
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I would like to thank the editors for their critical reading of this manuscript and Elizabeth Tamas and Gerone Gonzales for their help with the figures.
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Canton, J. (2022). Macropinocytosis in Phagocyte Function and Immunity. In: Commisso, C. (eds) Macropinocytosis. Subcellular Biochemistry, vol 98. Springer, Cham. https://doi.org/10.1007/978-3-030-94004-1_6
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