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Long Non-coding RNAs in Rheumatology

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Long Noncoding RNA

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1363))

Abstract

The last decade has seen an enormous increase in long non-coding RNA (lncRNA) research within rheumatology. LncRNAs are arbitrarily classed as non-protein encoding RNA transcripts that exceed 200 nucleotides in length. These transcripts have tissue and cell specific patterns of expression and are implicated in a variety of biological processes. Unsurprisingly, numerous lncRNAs are dysregulated in rheumatoid conditions, correlating with disease activity and cited as potential biomarkers and targets for therapeutic intervention. In this chapter, following an introduction into each condition, we discuss the lncRNAs involved in rheumatoid arthritis, osteoarthritis and systemic lupus erythematosus. These inflammatory joint conditions share several inflammatory signalling pathways and therefore not surprisingly many commonly dysregulated lncRNAs are shared across these conditions. In the interest of translational research only those lncRNAs which are strongly conserved have been addressed. The lncRNAs discussed here have diverse roles in regulating inflammation, proliferation, migration, invasion and apoptosis. Understanding the molecular basis of lncRNA function in rheumatology will be crucial in fully determining the inflammatory mechanisms that drive these conditions.

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Authors and Affiliations

  1. Institute of Inflammation and Ageing, MRC Versus Arthritis Centre for Musculoskeletal Ageing Research, University of Birmingham, Birmingham, UK

    Susanne N. Wijesinghe & Simon W. Jones

  2. Department of Pharmacy and Pharmacology, University of Bath, Bath, UK

    Mark A. Lindsay

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  1. Susanne N. Wijesinghe
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  2. Mark A. Lindsay
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Correspondence to Simon W. Jones .

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  1. Molecular Cell and Developmental Biology, University of California, Santa Cruz, Santa Cruz, CA, USA

    Susan Carpenter

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Wijesinghe, S.N., Lindsay, M.A., Jones, S.W. (2022). Long Non-coding RNAs in Rheumatology. In: Carpenter, S. (eds) Long Noncoding RNA. Advances in Experimental Medicine and Biology, vol 1363. Springer, Cham. https://doi.org/10.1007/978-3-030-92034-0_4

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