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NMDA Blockade

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Abstract

NMDA antagonists play an important role as anesthetics and analgesic agents. Ketamine may be used as a dissociative anesthetic and/or a nonopioid adjuvant in treatment of pain by offering significant analgesia while minimizing respiratory depression and offering relative hemodynamic stability. Methadone is a synthetic opioid with NMDA antagonistic and monoaminergic properties. It exhibits similar analgesia to morphine, but with a significantly longer half-life.

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Further Reading

  • Domino EF. Taming the ketamine tiger. Anesthesiology. 2010;70:469.

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  • Morgan and Mikhail. Clinical Anesthesiology, 5th edition; 2013:189–198.

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Author information

Authors and Affiliations

  1. Department of Anesthesiology & Perioperative Care, University of California- Irvine, Orange, CA, USA

    Austin H. Nguyen & Ariana M. Nelson

Authors
  1. Austin H. Nguyen
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  2. Ariana M. Nelson
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Corresponding author

Correspondence to Ariana M. Nelson .

Editor information

Editors and Affiliations

  1. Department of Anesthesiology, University of Minnesota, Minneapolis, MN, USA

    Ratan K. Banik

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Nguyen, A.H., Nelson, A.M. (2022). NMDA Blockade. In: Banik, R.K. (eds) Anesthesiology In-Training Exam Review. Springer, Cham. https://doi.org/10.1007/978-3-030-87266-3_72

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  • DOI: https://doi.org/10.1007/978-3-030-87266-3_72

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-87265-6

  • Online ISBN: 978-3-030-87266-3

  • eBook Packages: MedicineMedicine (R0)

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