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Metabolic Reprogramming and Cancer

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Essential Aspects of Immunometabolism in Health and Disease

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Abstract

Cancer cell metabolism reprograming has been investigated for many years. What started with the idea that cancer cells had respiratory deficiencies and survived by adapting to use the glycolytic pathway, is understood today as a complex and dynamic set of changes in metabolic pathways that are influenced by intrinsic (mutations, oncogene activity) and/or extrinsic (nutrient availability) factors. Metabolic reprogramming allows cancer cells to survive, proliferate and guarantee redox balance even in very adverse conditions. Moreover, metabolites secreted or depleted from the microenvironment by cancer cells influence the activity of stromal cells causing, for example, immune suppression. In this chapter, we will address cancer cell metabolism reprograming, identifying mechanisms that control metabolic pathways, as well, as the effects of these alterations on the tumor microenvironment and cancer cells themselves.

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Authors and Affiliations

  1. Instituto de Ciências Biomédicas, Universidade de São Paulo, Sao Paulo, Brazil

    Ana Paula Lepique, Enrique Boccardo & Flávia Sardela de Miranda

Authors
  1. Ana Paula Lepique
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  2. Enrique Boccardo
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  3. Flávia Sardela de Miranda
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Corresponding author

Correspondence to Ana Paula Lepique .

Editor information

Editors and Affiliations

  1. Laboratory of Transplantation Immunobiology, Department of Immunology, Institute of Biomedical Sciences IV, University of São Paulo, São Paulo, Brazil

    Niels Olsen Saraiva Camara

  2. Department of Pharmacology, University of São Paulo, São Paulo, Brazil

    Jose C Alves-Filho

  3. Laboratory of Immunometabolism, Department of Genetics, Evolution, Microbiology, and Immunology, Institute of Biology, University of Campinas, Campinas, São Paulo, Brazil

    Pedro Manoel Mendes de Moraes-Vieira

  4. Bernardo’s Lab, Center for Natural and Human Sciences, Federal University of ABC, São Paulo, Brazil

    Vinicius Andrade-Oliveira

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Lepique, A.P., Boccardo, E., de Miranda, F.S. (2022). Metabolic Reprogramming and Cancer. In: Camara, N.O.S., Alves-Filho, J.C., Moraes-Vieira, P.M.M.d., Andrade-Oliveira, V. (eds) Essential Aspects of Immunometabolism in Health and Disease. Springer, Cham. https://doi.org/10.1007/978-3-030-86684-6_9

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