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A Role for Fructose Metabolism in Development of Sheep and Pig Conceptuses

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Recent Advances in Animal Nutrition and Metabolism

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1354))

Abstract

The period of conceptus (embryo and extraembryonic membrane) development between fertilization and implantation in mammalian species is critical as it sets the stage for placental and fetal development. The trophectoderm and endoderm of pre-implantation ovine and porcine conceptuses undergo elongation, which requires rapid proliferation, migration, and morphological modification of the trophectoderm cells. These complex events occur in a hypoxic intrauterine environment and are supported through the transport of secretions from maternal endometrial glands to the conceptus required for the biochemical processes of cell proliferation, migration, and differentiation. The conceptus utilizes glucose provided by the mother to initiate metabolic pathways that provide energy and substrates for other metabolic pathways. Fructose, however, is in much greater abundance than glucose in amniotic and allantoic fluids, and fetal blood during pregnancy. Despite this, the role(s) of fructose is largely unknown even though a switch to fructosedriven metabolism in subterranean rodents and some cancers are key to their adaptation to hypoxic environments.

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Abbreviations

BNC:

Binucleated trophoblast giant cells

DHAP:

Dihydroxyacetone phosphate

ESR1:

Estrogen receptor α

F1P:

Fructose-1-phosphate

F6P:

Fructose-6-phosphate

G6P:

Glucose-6-phosphate

G6PDH:

Glucose-6-phosphate dehydrogenase

GAP:

Glyceraldehyde-3-phosphate

HIF1A:

Hypoxia inducible factor-1α

IFNT:

Interferon tau

KHK:

Ketohexokinase

LE:

Luminal epithelia

NAD+/NADH:

Nicotinamide adenine dinucleotide

NADP+/NADPH:

Nicotinamide adenine dinucleotide phosphate

OXTR:

Oxytocin receptor

PFK:

Phosphofructokinase-1

PGF2α:

Prostaglandin F2α

PHGDH:

Phosphoglycerate dehydrogenase

PPP:

Pentose phosphate pathway

PSPH:

Phosphoserine phosphatase

SHMT:

Serine hydroxymethyltransferase

SLC2A:

Facilitative glucose transporter family

SLC5A:

Sodium-dependent glucose transporter family

TCA:

Tricarboxylic acid cycle

TGC:

Multinucleated trophoblast giant cell

UDP-glcNAc:

Uridine diphosphate N-acetylglucosamine

VEGF:

Vascular endothelial growth factor

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Acknowledgements

Work in our laboratories was supported by Agriculture and Food Research Initiative Competitive Grant no. 2018-67015-28093 from the USDA National Institute of Food and Agriculture.

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Authors and Affiliations

  1. Departments of Animal Science and Veterinary Integrative Biosciences, Texas A&M University, College Station, TX, 77843, USA

    Robyn M. Moses, Avery C. Kramer, Heewon Seo, Guoyao Wu, Gregory A. Johnson & Fuller W. Bazer

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  1. Robyn M. Moses
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  2. Avery C. Kramer
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  3. Heewon Seo
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  4. Guoyao Wu
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  5. Gregory A. Johnson
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  6. Fuller W. Bazer
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Correspondence to Fuller W. Bazer .

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  1. Department of Animal Science, Texas A&M University, College Station, TX, USA

    Guoyao Wu

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Moses, R.M., Kramer, A.C., Seo, H., Wu, G., Johnson, G.A., Bazer, F.W. (2022). A Role for Fructose Metabolism in Development of Sheep and Pig Conceptuses. In: Wu, G. (eds) Recent Advances in Animal Nutrition and Metabolism. Advances in Experimental Medicine and Biology, vol 1354. Springer, Cham. https://doi.org/10.1007/978-3-030-85686-1_3

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