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Placenta, Umbilical Cord, and Umbilical Cord Blood-Derived Cultured Stromal Cells

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Orthobiologics

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Abstract

Placenta, umbilical cord, and umbilical cord blood have emerged as an alternative source to obtain stromal cells. This chapter provides an overview of the cell sourcing options for stromal cells derived from placental tissue, umbilical cord, and umbilical cord blood. There are various methods of collection, isolation, and culture expansion of the stromal cells obtained from these complex tissues to be used for future cell therapies. Detailed information regarding these methods obtained from the literature are summarized in this chapter.

We also provide a brief summary on the preclinical data that supports the ongoing exploration of these neonatal sources as opportunities for cellular therapies in the musculoskeletal system. The stromal cells isolated and culture-expanded from these neonatal sources have shown low immunogenicity, significant immunomodulatory effects, and anti-inflammatory effects. These cells have also shown prominent osteogenic and chondrogenic differentiation, as well as paracrine effects that support the regenerative potential in musculoskeletal healing in tissues such as cartilage and tendons. Therefore, the use of stromal cells obtained from the neonatal tissue sources seems to be promising for future cell therapy and regenerative medicine.

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Authors and Affiliations

  1. Department of Health Sciences and Technology, SAIHST, Sungkyunkwan University, Seoul, South Korea

    Jin-A Kim & Chul-Won Ha

  2. Stem Cell & Regenerative Medicine Research Institute, Samsung Medical Center, Seoul, South Korea

    Jin-A Kim & Chul-Won Ha

  3. Department of Orthopedic Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea

    Chul-Won Ha

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  1. Jin-A Kim
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  2. Chul-Won Ha
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Editors and Affiliations

  1. Rizzoli Orthopaedic Institute, Bologna, Italy

    Giuseppe Filardo

  2. Orthopaedic & Sports Medicine Group, Santa Monica Orthopaedic & Sports Medicine, Santa Monica, CA, USA

    Bert R. Mandelbaum

  3. Orthopaedic Surgery and Biomedical Engineering, Cleveland Clinic, Cleveland, OH, USA

    George F. Muschler

  4. Hospital for Special Surgery, New York, NY, USA

    Scott A. Rodeo

  5. Institute for Medical Science in Sports, Osaka Health Science University, Osaka, Japan

    Norimasa Nakamura

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Kim, JA., Ha, CW. (2022). Placenta, Umbilical Cord, and Umbilical Cord Blood-Derived Cultured Stromal Cells. In: Filardo, G., Mandelbaum, B.R., Muschler, G.F., Rodeo, S.A., Nakamura, N. (eds) Orthobiologics. Springer, Cham. https://doi.org/10.1007/978-3-030-84744-9_5

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