Abstract
The agroprocessing industries are producing a large volumes of waste biomass that contains valuable nutrients which if recycled properly could save millions of dollars. This is the case for the tea industry which produces large amounts of biomass from the tea plant, Camellia sinensis. Here, we review bioactive compounds from tea leaves, flowers and fruits, and their applications in medicine. Compounds include vitamins, aromatic compounds, spermidine derivatives, polysaccharides, saponins, polysaccharides, fatty acids, flavanols, phenolic acids and methylxanthenes. Pharmacological properties include antioxidant, antimicrobial, anti-COVID, antiobesity, antidiabetic, antihypertensive and anticancer.
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References
Abdou AM, Abdallah HM, Mohamed MA, Fawzy GA, Abdel-Naim AB (2013) A new anti-inflammatory triterpene saponin isolated from Anabasis setifera. Arch Pharm Res 36:715–722. https://doi.org/10.1007/s12272-013-0075-9
Agarwal U, Pathak DP, Bhutani R, Kapoor G, Kant R (2017) Review on Camellia sinensis –Nature’s Gift. Int J Pharmacogn Phytochem Res 9:1119–1126. https://doi.org/10.25258/phyto.v9i08.9619
Alrawaiq NS, Abdullah A (2014) A review of flavonoid quercetin: metabolism, bioactivity and antioxidant properties. Int. J. Pharm Tech Res 6:933–941
Alves AB, Bragagnolo N (2002) Simultaneous determination of theobromine, theophylline and caffeine in teas by high performance liquid chromatography. Braz J Pharm Sci 38:237–243. https://doi.org/10.1093/chromsci/40.1.45
Augustin JM, Kuzina V, Andersen SB, Bak S (2011) Molecular activities, biosynthesis and evolution of triterpenoid saponins. Phytochemistry 72:435–457. https://doi.org/10.1016/j.phytochem.2011.01.015
Baldermann S, Yang Z, Sakai M, Fleischmann P, Morita A, Todoroki Y, Watanabe N (2013) Influence of exogenously applied abscisic acid on carotenoid content and water uptake in flowers of the tea plant (Camellia sinensis). J Sci Food Agric 93:1660–1664. https://doi.org/10.1002/jsfa.5944
Bansal S, Choudhary S, Sharma M, Kumar SS, Lohan S, Bhardwaj V, Syan N, Jyoti S (2013) Tea: a native source of antimicrobial agents. Int Food Res 53:568–584. https://doi.org/10.1016/j.foodres.2013.01.032
Bassoli BK, Cassolla P, Borba-Murad GR, Constantin J, Salgueiro-Pagadigorria CL, Bazotte RB, da Silva RS, de Souza HM (2008) Chlorogenic acid reduces the plasma glucose peak in the oral glucose tolerance test: effects on hepatic glucose release and glycaemia. Cell Cell Biochem Funct 26:320–328. https://doi.org/10.1002/cbf.1444
Bayala B, Bassole IH, Scifo R, Gnoula C, Morel L, Lobaccaro JM, Simpore J (2014) Anticancer activity of essential oils and their chemical components-a review. Am J Cancer Res 4:591–607
Bhardwaj VK, Singh R, Sharma J, Rajendran V, Purohit R, Kumar S (2020) Identification of bioactive molecules from Tea plant as SARS-CoV-2 main protease inhibitors. J Biomol Struct Dyn:1–13. https://doi.org/10.1080/07391102.2020.1766572
Bonheure D, Willson KC, Clifford MN (1992) Tea cultivation to consumption. In: Mineral Nutrition and Fertilizers. Champman, Hall, pp 2–6
Carneiro BM, Batista MN, Braga AC, Nogueira ML, Rahal P (2016) The green tea molecule EGCG inhibits Zika virus entry. Virology 496:215–218. https://doi.org/10.1016/j.virol.2016.06.012
Chen AY, Chen YC (2013) A review of the dietary flavonoid, kaempferol on human health and cancer chemoprevention. Food Chem 138:2099–2107. https://doi.org/10.1016/j.foodchem.2012.11.139
Chen ZM, Lin Z (2015) Tea and human health: biomedical functions of tea active components and current issues. J Zhejiang Univ Sci B 6:87–102. https://doi.org/10.1631/jzus.B1500001
Chen ZY, Zhu QY, Tsang D, Huang Y (2001) Degradation of green tea catechins in tea drinks. J Agric Food Chem 49:477–482. https://doi.org/10.1021/jf000877h
Chen Z, Mei X, Jin Y, Kim EH, Yang Z, Tu Y (2014) Optimisation of supercritical carbon dioxide extraction of essential oil of flowers of tea (Camellia sinensis L.) plants and its antioxidative activity. J Sci Food Agric 94:316–321. https://doi.org/10.1002/jsfa.6260
Chen Y, Zhou Y, Zeng L, Dong F, Tu Y, Yang Z (2018) Occurrence of functional molecules in the flowers of tea (Camellia sinensis) plants: Evidence for a second resource. Molecules 23:790. https://doi.org/10.3390/molecules23040790
Cherng YG, Tsai CC, Chung HH, Lai YW, Kuo SC, Cheng JT (2013) Antihyperglycemic action of sinapic acid in diabetic rats. J Agric Food Chem 61:12053–12059. https://doi.org/10.1021/jf403092b
Choi SJ, Park SY, Park JS, Park SK, Jung MY (2016) Contents and compositions of policosanols in green tea (Camellia sinensis) leaves. Food Chem 204:94–101. https://doi.org/10.1016/j.foodchem.2016.02.027
Coffin CS, Lee SS (2015) New paradigms in hepatitis B management: only diamonds are forever. Br Med Bull 116:79–91. https://doi.org/10.1093/bmb/ldv039
Commisso M, Toffali K, Strazzer P, Stocchero M, Ceoldo S, Baldan B, Levi M, Guzzo F (2016) Impact of phenylpropanoid compounds on heat stress tolerance in carrot cell cultures. Front Plant Sci 7:1439. https://doi.org/10.3389/fpls.2016.01439
Da Silva PM (2013) Tea: A new perspective on health benefits. Int Food Res 53:558–567. https://doi.org/10.1016/j.foodres.2013.01.038
Das PR, Eun JB (2016) Phenolic acids in tea and coffee and their health benefits. In: Phenolic Acids: Properties, food sources and health effects. Nova Science Publishers, pp 129–194
Davis W, Lamson MS, Matthew S, Brignall ND (2000) Antioxidants and cancer III: quercetin. Altern Med Rev 5:196–208
Del Rio D, Stewart AJ, Mullen W, Burns J, Lean ME, Brighenti F, Crozier A (2004) HPLC-MSn analysis of phenolic compounds and purine alkaloids in green and black tea. J Agric Food Chem 52:2807–2815. https://doi.org/10.1021/jf0354848
Deryabin PG, Lvov DK, Botikov AG, Ivanov V, Kalinovsky T, Niedzwiecki A, Rath M (2008) Effects of a nutrient mixture on infectious properties of the highly pathogenic strain of avian influenza virus A/H5N1. Biofactors 33:85–97. https://doi.org/10.1002/biof.5520330201
Dhananjaya BL, Nataraju A, Gowda CR, Sharath BK, D’souza CJ (2009) Vanillic acid as a novel specific inhibitor of snake venom 5′-nucleotidase: a pharmacological tool in evaluating the role of the enzyme in snake envenomation. Biochemistry (moscow). Biochem Mosc 74:1315–1319. https://doi.org/10.1134/s0006297909120037
Dinda B, Debnath S, Mohanta BC, Harigaya Y (2010) Naturally occurring triterpenoid saponins. Chem Biodivers 7:2327–2580. https://doi.org/10.1002/cbdv.200800070
Dong F, Zhou Y, Zeng L, Peng Q, Chen Y, Zhang L, Su X, Watanabe N, Yang Z (2016) Elucidation of differential accumulation of 1-phenylethanol in flowers and leaves of tea (Camellia sinensis) plants. Molecules 21:1106. https://doi.org/10.3390/molecules21091106
Du LL, Fu QY, Xiang LP, Zheng XQ, Lu JL, Ye JH, Li QS, Polito CA, Liang YR (2016) Tea polysaccharides and their bioactivities. Molecules 21:1449. https://doi.org/10.20944/preprints201609.0013
Dulloo AG, Duret C, Rohrer D, Girardier L, Mensi N, Fathi M, Chantre P, Vandermander J (1999) Efficacy of a green tea extract rich in catechin polyphenols and caffeine in increasing 24-h energy expenditure and fat oxidation in humans. Am J Clin Nutr 70:1040–1045. https://doi.org/10.1093/ajcn/70.6.1040
Eng QY, Thanikachalam PV, Ramamurthy S (2018) Molecular understanding of Epigallocatechin gallate (EGCG) in cardiovascular and metabolic diseases. J Ethnopharmacol 210:296–310. https://doi.org/10.1016/j.jep.2017.08.035
Facchini PJ, Hagel J, Zulak KG (2002) Hydroxycinnamic acid amide metabolism: physiology and biochemistry. Can J Bot 80:577–589. https://doi.org/10.1139/b02-065
Fernandez PL, Pablos F, Martın MJ, Gonzalez AG (2002) Multi-element analysis of tea beverages by inductively coupled plasma atomic emission spectrometry. Food Chem 76:483–489. https://doi.org/10.1016/S0308-8146(01)00312-0
Forrest GI, Bendall DS (1969) The distribution of polyphenols in the tea plant (Camellia sinensis L.). Biochem J 113:741–755. https://doi.org/10.1042/bj1130741
Fredholm BB (1985) On the mechanism of action of theophylline and caffeine. Acta Med Scand 217:149–153. https://doi.org/10.1111/j.0954-6820.1985.tb01650.x
George KO, Kinyanjui T, Wanyoko J, Wachira F (2013) Extraction and analysis of tea (Camellia sinensis) seed oil from different clones in Kenya. Afr J Biotechnol 12:841–846. https://doi.org/10.3390/ijms12117708
Ghosh HN (2006) Tea and health: science behaind the myths. UBSPD
Goli AH, Barzegar M, Sahari MA (2005) Antioxidant activity and total phenolic compounds of pistachio (Pistachia vera) hull extracts. Food Chem 92:521–525. https://doi.org/10.1016/j.foodchem.2004.08.020
Gramza-Michałowska A, Bajerska-Jarzębowska J (2007) Leaves of Camellia sinensis: Ordinary brewing plant or super antioxidant source. Food, pp. 56–64
Granato D, do Prado-Silva L, Alvarenga VO, Zielinski AA, Bataglion GA, de Morais DR, Eberlin MN, Sant’Ana AD (2016) Characterization of binary and ternary mixtures of green, white and black tea extracts by electrospray ionization mass spectrometry and modeling of their in vitro antibacterial activity. Lwt-Food Sci Technol 65:414–420. https://doi.org/10.1016/j.lwt.2015.08.037
Guimarães AC, Meireles LM, Lemos MF, Guimarães MC, Endringer DC, Fronza M, Scherer R (2019) Antibacterial activity of terpenes and terpenoids present in essential oils. Molecules 24:2471. https://doi.org/10.3390/molecules24132471
Guo X, Song C, Ho CT, Wan X (2018) Contribution of l-theanine to the formation of 2, 5-dimethylpyrazine, a key roasted peanutty flavor in Oolong tea during manufacturing processes. Food Chem 263:18–28. https://doi.org/10.1016/j.foodchem.2018.04.117
Hamao M, Matsuda H, Nakamura S, Nakashima S, Semura S, Maekubo S, Wakasugi S, Yoshikawa M (2011) Anti-obesity effects of the methanolic extract and chakasaponins from the flower buds of Camellia sinensis in mice. Bioorg Med Chem 19:6033–6041. https://doi.org/10.1016/j.bmc.2011.08.042
Hara Y (2001) Green tea: health benefits and applications. CRC Press
Heleno SA, Ferreira IC, Calhelha RC, Esteves AP, Martins A, Queiroz MJ (2014) Cytotoxicity of Coprinopsis atramentaria extract, organic acids and their synthesized methylated and glucuronate derivatives. Food Res Int 55:170–175. https://doi.org/10.1016/j.foodres.2013.11.012
Heleno SA, Martins A, Queiroz MJ, Ferreira IC (2015) Bioactivity of phenolic acids: Metabolites versus parent compounds. Food Chem 13:173–501. https://doi.org/10.1016/j.foodchem.2014.10.057
Hemaiswarya S, Soudaminikkutty R, Narasumani ML, Doble M (2011) Phenylpropanoids inhibit protofilament formation of Escherichia coli cell division protein FtsZ. J Med Microbiol 60:1317–1312. https://doi.org/10.1099/jmm.0.030536-0
Henning SM, Yang J, Hsu M, Lee RP, Grojean EM, Ly A, Tseng CH, Heber D, Li Z (2018) Decaffeinated green and black tea polyphenols decrease weight gain and alter microbiome populations and function in diet-induced obese mice. Eur J Nutr 57:2759–2769. https://doi.org/10.1007/s00394-017-1542-8
Hollman PC, Van Trijp JM, Buysman MN, vd Gaag MS, Mengelers MJ, De Vries JH, Katan MB (1997) Relative bioavailability of the antioxidant flavonoid quercetin from various foods in man. FEBS Lett 418:52–156. https://doi.org/10.1016/s0014-5793(97)01367-7
Huang Q, Chen S, Chen H, Wang Y, Wang Y, Hochstetter D, Xu P (2013) Studies on the bioactivity of aqueous extract of pu-erh tea and its fractions: In vitro antioxidant activity and α-glycosidase inhibitory property, and their effect on postprandial hyperglycemia in diabetic mice. Food Chem Toxicol 53:75–83. https://doi.org/10.1016/j.fct.2012.11.039
Ishii T, Mori T, Ichikawa T, Kaku M, Kusaka K, Uekusa Y, Akagawa M, Aihara Y, Furuta T, Wakimoto T, Kan T (2010) Structural characteristics of green tea catechins for formation of protein carbonyl in human serum albumin. Bio organ Med Chem 18:4892–4896. https://doi.org/10.1016/j.bmc.2010.06.021
Jia S, Wang Y, Hu J, Ding Z, Liang Q, Zhang Y, Wang H (2016) Mineral and metabolic profiles in tea leaves and flowers during flower development. Plant Physiol Biochem 106:316–326. https://doi.org/10.1016/j.plaphy.2016.06.013
Jin Z, Du X, Xu Y, Deng Y, Liu M, Zhao Y, Zhang B, Li X, Zhang L, Peng C, Duan Y (2020) Structure of Mpro from COVID-19 virus and discovery of its inhibitors. Bio Rxiv doi. https://doi.org/10.1101/2020.02.26.964882
Joshi R, Gulati A (2011) Biochemical attributes of tea flowers (Camellia sinensis) at different developmental stages in the Kangra region of India. Sci Hortic 130:266–274. https://doi.org/10.1016/j.scienta.2011.06.007
Joubert E, Muller CJ, De Beer D, Johnson R, Chellan N, Louw J (2012) The potential role of phenolic acids in tea and herbal teas in modulating effects of obesity and diabetes. In: Phenolic acids: composition, applications and health benefits, 1st edn. Nova Science Publishers, New York, pp 172–211
Juneja LR, Chu DC, Okubo T, Nagato Y, Yokogoshi H (1999) L-theanine—a unique amino acid of green tea and its relaxation effect in humans. Trends Food Sci Technol 10:199–204. https://doi.org/10.1016/S0924-2244(99)00044-8
Jung UJ, Lee MK, Park YB, Jeon SM, Choi MS (2006) Antihyperglycemic and antioxidant properties of caffeic acid in db/db mice. J Pharmacol Exp Ther 318:476–483. https://doi.org/10.1124/jpet.106.105163
Kakuda T, Takihara T, Sakane I, Mortelmans K (1994) Antimicrobial activity of tea extracts against periodontopathic bacteria. Nippon Nōgei Kagakukaishi 68:241–243. https://doi.org/10.1271/nogeikagaku1924.68.241
Kao YH, Chang HH, Lee MJ, Chen CL (2006) Tea, obesity, and diabetes. Mol Nutr Food Res 50:88–210. https://doi.org/10.1002/mnfr.200500109
Karimi E, Jaafar HZ, Ghasemzadeh A, Ebrahimi M (2015) Fatty acid composition, antioxidant and antibacterial properties of the microwave aqueous extract of three varieties of Labisia pumila Benth. Biol Res 48:9. https://doi.org/10.1186/0717-6287-48-9
Katiyar S, Mukhtar HA (1996) Tea in chemoprevention of cancer. Int J Oncol 8:221–238. https://doi.org/10.3892/ijo.8.2.221
Kato M, Kitao N, Ishida M, Morimoto H, Irino F, Mizuno K (2009) Expression for caffeine biosynthesis and related enzymes in Camellia sinensis. Z Naturforsch C J Biosci 65:245–256. https://doi.org/10.1515/znc-2010-3-413
Khan SH, Iqbal J (2016) Recent advances in the role of organic acids in poultry nutrition. J Appl Anim Res 44:359–369. https://doi.org/10.1080/09712119.2015.1079527
Koch W, Kukula-Koch W, Komsta Ł, Marzec Z, Szwerc W, Głowniak K (2018) Green tea quality evaluation based on its catechins and metals composition in combination with chemometric analysis. Molecules 23:1689. https://doi.org/10.3390/molecules23071689
Kubo I, Muroi H, Himejima M (1992) Antimicrobial activity of green tea flavor components and their combination effects. J Agr Food Chem 40:245–248. https://doi.org/10.1021/jf00014a015
Kumar S, Pandey AK (2013) Chemistry and biological activities of flavonoids: an overview. Sci World J:1–16. https://doi.org/10.1155/2013/162750
Kumari M, Pattnaik B, Rajan SY, Shrikant S, Surendra SU (2017) EGCG-A Promis anti-cancer. Phytochemistry 3:8–10. https://doi.org/10.21276/aimdr.2017.3.2.DE3
Kuroda Y, Hara Y (2004) Health effects of tea and its catechins. Springer
Lee SR, Suh SI, Kim SP (2000) Protective effects of the green tea polyphenol (−)-epigallocatechin gallate against hippocampal neuronal damage after transient global ischemia in gerbils. Neurosci Lett 287:191–194. https://doi.org/10.1016/s0304-3940(00)01159-9
Li C, Wang Y (2009) Mineral elements in different varieties of Camellia sinensis. Agr Sci Tech-Hunan 10:105–107
Liang YR, Liu ZS, Xu YR, Hu YL (1990) A study on chemical composition of two special green teas (Camellia sinensis). J Sci Food Agric 53:541–548. https://doi.org/10.1002/jsfa.2740530411
Lin YS, Wu SS, Lin JK (2003) Determination of tea polyphenols and caffeine in tea flowers (Camellia sinensis) and their hydroxyl radical scavenging and nitric oxide suppressing effects. J Agric Food Chem 51:975–980. https://doi.org/10.1021/jf020870v
Ma SJ, Mizutani M, Hiratake J, Hayashi K, Yagi K, Watanabe N, Sakata K (2014) Substrate specificity of 8-primeverosidase, aroma formation during oolong tea and black tea. Biosci Biotech Bioch 65:2719–2729. https://doi.org/10.1021/jf001077%2B
Makris DP, Boskou G, Andrikopoulos NK (2007) Polyphenolic content and in vitro antioxidant characteristics of wine industry and other agri-food solid waste extracts. J Food Compos Anal 20:125–132. https://doi.org/10.1016/j.jfca.2006.04.010
Man S, Gao W, Zhang Y, Huang L, Liu C (2010) Chemical study and medical application of saponins as anti-cancer agents. Fitoterapia 81:703–714. https://doi.org/10.1016/j.fitote.2010.06.004
Mandal M, Das K, Nandi DK, Das B, Sreenivas RJ (2019) Analysis Of Fatty Acids From Oil Of Green Tea (Camellia Sinensis L) By Gas Chromatography Coupled With Flame Ionization Detector And Its Anticancer And Antibacterial Activity In Vitro. Int J Pharm Pharm Sci 11:104–111. https://doi.org/10.22159/ijpps.2019v11i3.29888
Mani-López E, García HS, López-Malo A (2012) Organic acids as antimicrobials to control Salmonella in meat and poultry products. Food Res Int 45:713–721. https://doi.org/10.1016/j.foodres.2011.04.043
Manir MM, Kim JK, Lee BG, Moon SS (2012) Tea catechins and flavonoids from the leaves of Camellia sinensis inhibit yeast alcohol dehydrogenase. Bioorg Med Chem 20:2376–2378. https://doi.org/10.1016/j.bmc.2012.02.002
Maqbool MA, Aslam M, Akbar W, Iqbal Z (2018) Biological importance of vitamins for human health: A review. J Agric Sci 2:50–58
Martínez-Pinilla E, Oñatibia-Astibia A, Franco R (2015) The relevance of theobromine for the beneficial effects of cocoa consumption. Front Pharmacol 6. https://doi.org/10.3389/fphar.2015.00030
Mishra A, Sharma AK, Kumar S, Saxena AK, Pandey AK (2013) Bauhinia variegata leaf extracts exhibit considerable antibacterial, antioxidant, and anticancer activities. Biomed Res Int 915436:10. https://doi.org/10.1155/2013/915436
Monobe M, Nomura S, Ema K, Matsunaga A, Nesumi A, Yoshida K, Maeda-Yamamoto M, Horie H (2015) Quercetin glycosides-rich tea cultivars (Camellia sinensis L.) in Japan. Food Sci Technol Res 21:333–340. https://doi.org/10.3136/fstr.21.333
Muhlemann JK, Maeda H, Chang CY, San Miguel P, Baxter I, Cooper B, Perera MA, Nikolau BJ, Vitek O, Morgan JA, Dudareva N (2012) Developmental changes in the metabolic network of snapdragon flowers. PLoS One 7:40381. https://doi.org/10.1371/journal.pone.0040381
Mukoyama A, Ushijima H, Nishimura S, Koike H, Toda M, Hara Y, Shimamura T (1991) Inhibition of rotavirus and enterovirus infections by tea extracts. Jpn J Med Sci Biol 44:81–186. https://doi.org/10.7883/yoken1952.44.181
Nagao T, Hase T, Tokimitsu I (2007) A green tea extract high in catechins reduces body fat and cardiovascular risks in humans. Obesity (Silver Spring) 15:1473–1483. https://doi.org/10.1038/oby.2007.176
Narayan MS, Bhattacharya B, Dhanaraj N, Seshadri R (1988) Free and bound triacontanol in tea leaves. J Sci Food Agric 43:229–233. https://doi.org/10.1002/jsfa.2740430305
Neelam KA, Sharma KK (2020) Phenylpropanoids and its derivatives: biological activities and its role in food, pharmaceutical and cosmetic industries. Crit Rev Food Sci Nutr:1–21. https://doi.org/10.1080/10408398.2019.1653822
Neish AC (1960) Biosynthetic pathways of aromatic compounds. Annu Rev Plant Physiol 11:55–80. https://doi.org/10.1146/annurev.pp.11.060160.000415
Nie SP, Xie MY (2011) A review on the isolation and structure of tea polysaccharides and their bioactivities. Food Hydrocoll 25:144–149. https://doi.org/10.1016/j.foodhyd.2010.04.010
Nurminen ML, Niittynen L, Korpela R, Vapaatalo H (1999) Coffee, caffeine and blood pressure: a critical review. Eur J Clin Nutr 53:831–839. https://doi.org/10.1038/sj.ejcn.1600899
Ozarowski M, Piasecka A, Paszel-Jaworska A, Chaves DS, Romaniuk A, Rybczynska M, Gryszczynska A, Sawikowska A, Kachlicki P, Mikolajczak PL, Seremak-Mrozikiewicz A (2018) Comparison of bioactive compounds content in leaf extracts of Passiflora incarnata, P. caerulea and P. alata and in vitro cytotoxic potential on leukemia cell lines. Rev Bras Farmacogn 28:179–191. https://doi.org/10.1016/j.bjp.2018.01.006
Paduch R, Trytek M, Król SK, Kud J, Frant M, Kandefer-Szerszeń M, Fiedurek J (2016) Biological activity of terpene compounds produced by biotechnological methods. Pharm Biol 54:1096–1107. https://doi.org/10.3109/13880209.2015.1103753
Pang J, Choi Y, Park T (2008) Ilex paraguariensis extract ameliorates obesity induced by high-fat diet: potential role of AMPK in the visceral adipose tissue. Arch Biochem Biophys 476:178–185. https://doi.org/10.1016/j.abb.2008.02.019
Quan H, Qiong-Yao Y, Jiang S, Chang-Yun X, Ze-Jie L, Pu-Ming H (2011) Structural characterization and antioxidant activities of 2 water-soluble polysaccharide fractions purified from tea (Camellia sinensis) flower. J Food Sci 76:62–71. https://doi.org/10.1111/j.1750-3841.2011.02063.x
Rana A, Singh HP, Gulati A (2015) Investigation of major phenolic antioxidants from Camellia sinensis fruits. Cogent Chem 1:1080652. https://doi.org/10.1080/23312009.2015.1080652
Rana A, Sharma E, Rawat K, Sharma R, Verma S, Padwad Y, Gulati A (2016) Screening and purification of catechins from underutilized tea plant parts and their bioactivity studies. J Food Sci Tech 53:4023–4032. https://doi.org/10.1007/s13197-016-2406-6
Rao JM, Natarajan CP, Seshadri R (1987) A study on the occurrence of N-triacontanol, a plant growth regulator, in tea. J Sci Food Agric 39:95–99. https://doi.org/10.1002/jsfa.2740390202
Ravichandran R (2002) Carotenoid composition, distribution and degradation to flavour volatiles during black tea manufacture and the effect of carotenoid supplementation on tea quality and aroma. Food Chem 78:23–28. https://doi.org/10.1016/S0308-8146(01)00303-X
Reto M, Figueira ME, Filipe HM, Almeida CM (2007) Analysis of vitamin K in green tea leafs and infusions by SPME–GC-FID. Food Chem 100:405–411. https://doi.org/10.1016/j.foodchem.2005.09.016
Rice-Evans CA, Miller NJ, Paganga G (1996) Structure-antioxidant activity relationships of flavonoids and phenolic acids. Free Radic Biol Med 20:933–956. https://doi.org/10.1016/0891-5849(95)02227-9
Saijo R, Takeo T (1973) Volatile and non-volatile forms of aroma compounds in tea leaves and their changes due to injury. Agric Biol Chem 37:1367–1373. https://doi.org/10.1080/00021369.1973.10860844
Sakanaka S, Aizawa M, Kim M, Yamamoto T (1996) Inhibitory effects of green tea polyphenols on growth and cellular adherence of an oral bacterium, Porphyromonas gingivalis. Biosci Biotech Bioch 60:745–749. https://doi.org/10.1271/bbb.60.745
Sandeep K, Nisha S (2012) Green tea polyphenols: versatile cosmetic ingredient. Int J Adv Res Pharm Bio Sci 1:348–363
Sanderson GW, Selvendran RR (1965) The organic acids in tea plants. A study of the non-volatile organic acids separated on silica gel. J Sci Food Agric 16:251–258. https://doi.org/10.1002/jsfa.2740160504
Sanderson GW, Berkowitz JE, Co H, Graham HN (1972) Biochemistry of tea fermentation: products of the oxidation of tea flavanols in a model tea fermentation system. J Food Sci 37:399–404. https://doi.org/10.1111/j.1365-2621.1972.tb02648.x
Schinzari V, Barnaba V, Piconese S (2015) Chronic hepatitis B virus and hepatitis C virus infections and cancer: Synergy between viral and host factors. Clin Microbiol Infect 21:969–974. https://doi.org/10.1016/j.cmi.2015.06.026
Schwalfenberg G, Genuis SJ, Rodushkin I (2013) The benefits and risks of consuming brewed tea: beware of toxic element contamination. J Toxicol. https://doi.org/10.1155/2013/370460
Semwal DK, Semwal RB, Combrinck S, Viljoen A (2016) Myricetin: A dietary molecule with diverse biological activities. Nutrients 8:90. https://doi.org/10.3390/nu8020090
Seo HS, Jo JK, Ku JM, Choi HS, Choi YK, Woo JK, Kang SY, Nam KW, Park N, Jang BH, Shin YC (2015) Induction of caspase-dependent extrinsic apoptosis by apigenin through inhibition of signal transducer and activator of transcription 3 (STAT3) signalling in HER2-overexpressing BT-474 breast cancer cells. Biosci Rep 35. https://doi.org/10.1042/BSR20150165
Sharma E, Joshi R, Gulati A (2018a) L-Theanine: an astounding sui generis integrant in tea. Food Chem 242:601–610. https://doi.org/10.1016/j.foodchem.2017.09.046
Sharma R, Verma S, Rana S, Rana A (2018b) Rapid screening and quantification of major organic acids in citrus fruits and their bioactivity studies. J Food Sci Tech. https://doi.org/10.1007/s13197-018-3045-x
Sharma R, Rana A, Kumar S (2020) Phytochemical investigation and bioactivity studies of flowers obtained from different cultivars of C. sinensis plant. Natural Product Research. (ID: 1844696, https://doi.org/10.1080/14786419.2020.1844696)
Sies H, Stahl W, Sundquist AR (1992) Antioxidant functions of vitamins: Vitamins E and C, Beta-Carotene, and other carotenoids A. Ann N Y Acad Sci 669:7–20. https://doi.org/10.1111/j.1749-6632.1992.tb17085.x
Singh S, Sharma B, Kanwar SS, Kumar A (2016) Lead phytochemicals for anticancer drug development. Front Plant Sci 7:1667. https://doi.org/10.3389/fpls.2016.01667
Song Y, Manson JE, Buring JE, Sesso HD, Liu S (2005) Associations of dietary flavonoids with risk of type 2 diabetes, and markers of insulin resistance and systemic inflammation in women: a prospective study and cross-sectional analysis. J Am Coll Nutr 24:376–384. https://doi.org/10.1080/07315724.2005.10719488
Stahl W, Sies H (2005) Bioactivity and protective effects of natural carotenoids. Biochim Biophys Acta Mol basis Dis 1740:101–107. https://doi.org/10.1016/j.bbadis.2004.12.006
Sulochana KN, Rajesh M, Ramakrishnan S (2001) Insulin receptor tyrosine kinase activity in monocytes of type 2 diabetes mellitus patients receiving oral L-lysine. Indian J Biochem Biophys 38:331–334. http://hdl.handle.net/123456789/15312
Sung YY, Kim DS, Kim HK (2015) Akebia quinata extract exerts anti-obesity and hypolipidemic effects in high-fat diet-fed mice and 3T3-L1 adipocytes. J Ethnopharmacol 168:7–24. https://doi.org/10.1016/j.jep.2015.03.051
Sur P, Chaudhuri T, Vedasiromoni JR, Gomes A, Ganguly DK (2001) Antiinflammatory and antioxidant property of saponins of tea [Camellia sinensis (L) O. Kuntze] root extract. Phytother Res 15:174–176. https://doi.org/10.1002/ptr.696
Suzuki Y, Shioi Y (2003) Identification of chlorophylls and carotenoids in major teas by high-performance liquid chromatography with photodiode array detection. J Agric Food Chem 51:5307–5314. https://doi.org/10.1021/jf030158d
Suzuki T, Waller GR (1985) Purine alkaloids of the fruits of Camellia sinensis L. and Coffea arabica L. during fruit development. Ann. Bot 56:537–542. https://doi.org/10.1093/oxfordjournals.aob.a087038
Tamura M, Ochiai K (2012) Exploring the possible applications of catechin (gel) for oral care of the elderly and disabled individuals. Jpn Dent Sci Rev 48:126–134. https://doi.org/10.1016/j.jdsr.2012.02.004
Tanaka T, Matsuo Y, Kouno I (2013) Biochemical and physicochemical characteristics of green tea polyphenols. Green Tea Polyphenols: Nutraceuticals of Modern Life. CRC Press
Tea G (2005) Functional foods and products from Japanese. In: Asian functional foods. CRC Press, pp 547–558
Tuan HQ, Thinh ND, Minh TNT (2016) Changes in composition of flavour precursor amino acid in leaves of tea (Camellia sinensis) during orthodox black tea processing. J Sci Technol 55:1–7. https://doi.org/10.15625/0866-708X/55/1/8318
Van RO, Zwaluw NL, Groot LC (2013) Literature review on the role of dietary protein and amino acids in cognitive functioning and cognitive decline. Amino Acids 45:1035–1045. https://doi.org/10.1007/s00726-013-1583-0
Waltner-Law ME, Wang XL, Law BK, Hall RK, Nawano M, Granner DK (2002) Epigallocatechin gallate, a constituent of green tea, represses hepatic glucose production. J Biol Chem 277:34933–34940. https://doi.org/10.1074/jbc.M204672200
Wang Y, Yu L, Zhang J, Xiao J, Wei X (2010) Study on the purification and characterization of a polysaccharide conjugate from tea flowers. Int J Biol Macromol 47:266–270. https://doi.org/10.1016/j.ijbiomac.2010.04.011
Wang Y, Sun D, Chen H, Qian L, Xu P (2011) Fatty acid composition and antioxidant activity of tea (Camellia sinensis L.) seed oil extracted by optimized supercritical carbon dioxide. Int J Mol Sci 12:7708–7719. https://doi.org/10.3390/ijms12117708
Wang Y, Huang S, Shao S, Qian L, Xu P (2012) Studies on bioactivities of tea (Camellia sinensis L.) fruit peel extracts: Antioxidant activity and inhibitory potential against α-glucosidase and α-amylase in vitro. Ind Crop Prod 37:520–526. https://doi.org/10.1016/j.indcrop.2011.07.031
Wei X, Chen M, Xiao J, Liu Y, Yu L, Zhang H, Wang Y (2010) Composition and bioactivity of tea flower polysaccharides obtained by different methods. Carbohyd Polym 79:418–422. https://doi.org/10.1016/j.carbpol.2009.08.030
Winterhalter P, Rouseff RL (2001) Carotenoid-derived aroma compounds. American Chemical Society
Wu LY, Juan CC, Hwang LS, Hsu YP, Ho PH, Ho LT (2004) Green tea supplementation ameliorates insulin resistance and increases glucose transporter IV content in a fructose-fed rat model. Eur J Nutr 43:116–124. https://doi.org/10.1007/s00394-004-0450-x
Xu R, Ye H, Sun Y, Tu Y, Zeng X (2012) Preparation, preliminary characterization, antioxidant, hepatoprotective and antitumor activities of polysaccharides from the flower of tea plant (Camellia sinensis). Food Chem Toxicol 50:2473–2480. https://doi.org/10.1016/j.fct.2011.10.047
Xu DP, Li Y, Meng X, Zhou T, Zhou Y, Zheng J, Zhang JJ, Li HB (2017) Natural antioxidants in foods and medicinal plants: Extraction, assessment and resources. Int J Mol Sci 18(96). https://doi.org/10.3390/ijms18010096
Xue CC, Zhang AL, Lin V, Da Costa C, Story DF (2007) Complementary and alternative medicine use in Australia: a national population-based survey. J Altern Complement Med 13:643–650. https://doi.org/10.1089/acm
Yanaida Y, Kohno H, Yoshida K, Hirose Y, Yamada Y, Mori H, Tanaka T (2002) Dietary silymarin suppresses 4-nitroquinoline 1-oxide-induced tongue carcinogenesis in male F344 rats. Carcinogenesis 23:787–794. https://doi.org/10.1093/carcin/23.5.787
Yang Z, Tu Y, Baldermann S, Dong F, Xu Y, Watanabe N (2009) Isolation and identification of compounds from the ethanolic extract of flowers of the tea (Camellia sinensis) plant and their contribution to the antioxidant capacity. LWT-Food Sci Technol 42:1439–1443. https://doi.org/10.1016/J.LWT.2009.03.017
Yang Z, Dong F, Baldermann S, Murata A, Tu Y, Asai T, Watanabe N (2012) Isolation and identification of spermidine derivatives in tea (Camellia sinensis) flowers and their distribution in floral organs. J Sci Food Agric 92:2128–2132. https://doi.org/10.1002/jsfa.5596
Yao L, Jiang Y, Datta N, Singanusong R, Liu X, Duan J, Raymont K, Lisle A, Xu Y (2004) HPLC analyses of flavanols and phenolic acids in the fresh young shoots of tea (Camellia sinensis) grown in Australia. Food Chem 84:253–263. https://doi.org/10.1016/S0308-8146(03)00209-7
Yin MC, Lin CC, Wu HC, Tsao SM, Hsu CK (2009) Apoptotic effects of protocatechuic acid in human breast, lung, liver, cervix, and prostate cancer cells: potential mechanisms of action. J Agr Food Chem 57:6468–6473. https://doi.org/10.1021/jf9004466
Yoshikawa M, Morikawa T, Yamamoto K, Kato Y, Nagatomo A, Matsuda H (2005) Floratheasaponins A− C, acylated oleanane-type triterpene oligoglycosides with anti-hyperlipidemic activities from flowers of the tea plant (Camellia sinensis). J Nat Prod 68:1360–1365. https://doi.org/10.1021/np0580614
Zaprometov MN (1967) Biochemistry of phenolic compounds. Usp Sovrem Biol
Zhang L, Ho CT, Zhou J, Santos JS, Armstrong L, Granato D (2019) Chemistry and biological activities of processed Camellia sinensis teas: A comprehensive review. Compr Rev Food Sci F. https://doi.org/10.1111/1541-4337.12479
Zhao X, Chen S, Wang S, Shan W, Wang X, Lin Y, Su F, Yang Z, Yu X (2020) Defensive responses of tea plants (Camellia sinensis) against tea green leafhopper attack: a multi-omics study. Front Plant Sci 10:1705. https://doi.org/10.3389/fpls.2019.01705
Acknowledgments
Authors are also thankful to Council of Scientific and Industrial Research (CSIR) New Delhi India and Department of Science & Technology, New Delhi, for award of Women Scientist Scheme (WOS-A) to RS (GAP- 0239). AR is thankfull to BIRAC, DBT India for financial support through BIPP scheme.
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Sharma, R., Rana, A., Kumar, D., Kumar, S. (2021). Exploration of Bioactive Constituents from Abandoned Parts of the Tea Plant. In: Rana, A., Saneja, A., Kumar, S., Lichtfouse, E. (eds) Sustainable Agriculture Reviews 56. Sustainable Agriculture Reviews, vol 56. Springer, Cham. https://doi.org/10.1007/978-3-030-84405-9_6
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