Abstract
Histoplasma capsulatum is a major endemic mycosis. Our laboratories have demonstrated that H. capsulatum produces extracellular vesicles (EV) that are loaded with diverse compounds that influence virulence. We have further shown that H. capsulatum dynamically regulates the loading and release of fungal EV in response to stimuli and growth conditions. This chapter details the current knowledge of EV biology in H. capsulatum and the impact of this information on our understanding of this important process that is closely linked to pathogenesis.
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Acknowledgement
J.D.N., E.S.N., and D.Z-M were supported in part by NIH R21AI124797. LRA received financial support from Inova Fiocruz/Fundação Oswaldo Cruz [Grant number VPPCB-07-FIO-18-2-52] and CNPq [Grant number 442317/2019-0]. L.R.A is a research fellow awardee from CNPq.
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Zamith-Miranda, D., Alves, L.R., Nakayasu, E.S., Nosanchuk, J.D. (2021). Lessons Learned from Studying Histoplasma capsulatum Extracellular Vesicles. In: Rodrigues, M., Janbon, G. (eds) Fungal Extracellular Vesicles. Current Topics in Microbiology and Immunology, vol 432. Springer, Cham. https://doi.org/10.1007/978-3-030-83391-6_2
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DOI: https://doi.org/10.1007/978-3-030-83391-6_2
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