Abstract
While FDG is the most commonly used tracer in PET imaging, there are other radiotracers that may be used to aid in localizing an epileptogenic focus. Many of these radiotracers allow for neurotransmitter receptor imaging, levels of which are usually altered in epilepsy due to increased neuronal activity or low levels of inhibitory neurotransmitters [1]. For example, gamma-aminobutyric acid (GABA) is one of the most important inhibitory neurotransmitters, and 11C-flumazenil (FMZ) PET exams target the benzodiazepine sensitive sites of GABAA receptors. These exams usually show decreased tracer binding in epileptogenic foci [2], with increased accuracy as compared to FDG PET exams [3]. However, the common use of this exam is limited by the short half-life (20.38 minutes) of the radiotracer.
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Chiu, A., Zeineh, M. (2022). Future Trends in Epilepsy Imaging. In: Franceschi, A.M., Franceschi, D. (eds) Hybrid PET/MR Neuroimaging. Springer, Cham. https://doi.org/10.1007/978-3-030-82367-2_45
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DOI: https://doi.org/10.1007/978-3-030-82367-2_45
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