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Novel Organic and Inorganic Nanoparticles as a Targeted Drug Delivery Vehicle in Cancer Treatment

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Emerging Nanomaterials for Advanced Technologies

Part of the book series: Nanotechnology in the Life Sciences ((NALIS))

Abstract

Cancer arises when the homeostatic balance between cell growth and death is disturbed. A current standard treatment for cancer not only targets cancer cells but also affects normal cells. Nanotechnology is the most advanced in the field of medicine. Nanoparticles or nanocarriers have a wide range of applications like targeted drug releasing capacity, sustainability, and high permeability at tumor tissues. Our aim is to couple anticancer drugs with nano-based encapsulation technology, for treating primary or advanced metastatic tumors. Organic and inorganic nanoparticles like polymeric micelles, liposomes, dendrimers, silica, gold, silver, carbon nanotubes, quantum dots, nanographene, and magnetic nanoparticles serve the above purpose. This review paper aims to cover the advantages of organic and inorganic nanoparticles as a novel drug carrier vehicle in cancer treatment in order to overcome the limitations of conventional drugs.

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Abbreviations

5FU:

5-Fluorouracil

AITC-SiQDs:

Allyl isothiocyanate-silicon QDs

AKT/mTOR:

Serine/threonine-specific protein kinase/mechanistic target of rapamycin kinase

APAF1:

Apoptotic protease activating factor 1

AuNPs:

Gold nanoparticle

Bcl-2 :

B-cell lymphoma 2

CNTs:

Carbon nanotubes

DSC:

Differential scanning calorimetry

EGF:

Epidermal growth factor

FA-NGO-PVP:

Folic acid-graphene oxide-polyvinylpyrrolidone

FDA:

Food and Drug Administration

GA-CdTe:

Gambogic acid-cadmium-tellurium

GO-PVCL:

Graphene oxide-poly N-vinyl caprolactam

HA:

Hyaluronic acid

HA-DOX-GQD@MSN:

Hyaluronic acid-doxorubicin-N-graphene quantum dots-mesoporous silica nanoparticles

HCC:

Hepatocellular carcinoma

HER2 genes:

Human epidermal growth factor receptor-2 genes

HPMA:

N-2-hydroxypropyl methacrylamide

IGF1R:

Type I insulin-like growth factor receptor

MALDI-MS:

Matrix-assisted laser desorption ionization-mass spectrometry

MMP:

Matrix Metallo Proteinases

NF-kB:

Nuclear factor-κB

NGO-HA:

Nanographene oxide-hyaluronic acid

NIPAAM:

N-isopropylacrylamide

NMR:

Nuclear magnetic resonance

PAMAM:

Polyamidoamine

PEDOT:PSS:

Poly 3,4-ethylenedioxythiophene-poly styrenesulfonate

PEG:

Polyethylene glycol

PEG-A:

Polyethylene glycol monoacrylate

PEG-PE:

Polyethylene glycol-phosphatidyl ethanolamine

PEO-PCL:

Polyethylene oxide-poly epsilon-caprolactone

PLA-PEG-PLL- DTPA:

Poly lactic acid-polyethylene glycol-poly L-lysine-diethylene Triamine pentaacetic acid

PLGA:

Poly D,L-lactic acid-co-glycolic acid

PLGA:

Polylactide-co-glycolide

PLH-PEG-biotin:

Poly L-histidine-polyethylene glycol-biotin

PPI:

Polypropylene imine

PTT:

Photothermal therapy

QDs:

Quantum dots

ROS:

Reactive oxygen species

SEM:

Scanning electron microscope

TEM:

Transmission electron microscopy

TPTN:

Theranostic polymeric nanoparticle

TRC-NPs:

Thermo-responsive chitosan-g-poly (N-vinylcaprolactam) nanoparticles

VP:

N-vinyl-2-pyrrolidone

γ-PGA:

Polyvinyl pyrrolidone and poly-γ-glutamic acid

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Author notes

  1. Kiruthiga Palanisamy, Gayathiri Gunasangkaran and Anjali K. Ravi contributed equally with all other contributors.

Authors and Affiliations

  1. Department of Biochemistry, Bharathiar University, Coimbatore, Tamil Nadu, India

    Saradhadevi Muthukrishnan, Kiruthiga Palanisamy, Gayathiri Gunasangkaran & Anjali K. Ravi

  2. Department of Human Genetics and Molecular Genetics, Bharathiar University, Coimbatore, Tamil Nadu, India

    A. Vijaya Anand

  3. Department of Food Science and Biotechnology, Sejong University, Seoul, South Korea

    Balamuralikrishnan Balasubramanian

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  1. Saradhadevi Muthukrishnan
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  2. A. Vijaya Anand
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  3. Kiruthiga Palanisamy
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  4. Gayathiri Gunasangkaran
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  5. Anjali K. Ravi
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  6. Balamuralikrishnan Balasubramanian
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Correspondence to Saradhadevi Muthukrishnan .

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Editors and Affiliations

  1. Department of Chemical Pathology, University of the Free State, Bloemfontein, Free State, South Africa

    Anand Krishnan

  2. Department of Environment Energy and Engineering, Kyonggi University, Suwon-si, Korea (Republic of)

    Balasubramani Ravindran

  3. Department of Food Science and Biotechnology, Sejong University, Seoul, Korea (Republic of)

    Balamuralikrishnan Balasubramanian

  4. Department of Physics, University of the Free State, Bloemfontein, South Africa

    Hendrik C. Swart

  5. School of Chemistry and Physics, University of KwaZulu Natal, Durban, South Africa

    Sarojini Jeeva Panchu

  6. Department of Botany, Mahatma Gandhi Central University/ Bihar, Motihari, Bihar, India

    Ram Prasad

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Muthukrishnan, S., Anand, A.V., Palanisamy, K., Gunasangkaran, G., Ravi, A.K., Balasubramanian, B. (2022). Novel Organic and Inorganic Nanoparticles as a Targeted Drug Delivery Vehicle in Cancer Treatment. In: Krishnan, A., Ravindran, B., Balasubramanian, B., Swart, H.C., Panchu, S.J., Prasad, R. (eds) Emerging Nanomaterials for Advanced Technologies. Nanotechnology in the Life Sciences. Springer, Cham. https://doi.org/10.1007/978-3-030-80371-1_4

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