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Role of the J Domain Protein Family in the Survival and Pathogenesis of Plasmodium falciparum

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Heat Shock Proteins of Malaria

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1340))

Abstract

Plasmodium falciparum has dedicated an unusually large proportion of its genome to molecular chaperones (2% of all genes), with the heat shock protein 40 (Hsp40) family (now called J domain proteins, JDPs) exhibiting evolutionary radiation into 49 members. A large number of the P. falciparum JDPs (PfJDPs) are predicted to be exported, with certain members shown experimentally to be present in the erythrocyte cytosol (PFA0660w and PFE0055c) or erythrocyte membrane (ring-infected erythrocyte surface antigen, RESA). PFA0660w and PFE0055c are associated with an exported plasmodial Hsp70 (PfHsp70-x) within novel mobile structures called J-dots, which have been proposed to be dedicated to the trafficking of key membrane proteins such as erythrocyte membrane protein 1 (PfEMP1). Well over half of the PfJDPs appear to be essential, including the J-dot PfJDP, PFE0055c, while others have been found to be required for growth under febrile conditions (e.g. PFA0110w, the ring-infected erythrocyte surface antigen protein [RESA]) or involved in pathogenesis (e.g. PF10_0381 has been shown to be important for protrusions of the infected red blood cell membrane, the so-called knobs). Here we review what is known about those PfJDPs that have been well characterised, and may be directly or indirectly involved in the survival and pathogenesis of the malaria parasite.

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Acknowledgements

TD and GLB are thankful for financial assistance from The University of Notre Dame Australia. E-RP gratefully acknowledges funding from the Victoria University Research Development Grant Scheme. AGM is kindly supported by the Australian Research Council (DP180103212) and the National Health and Medical Research Council of Australia (APP1182369).

Author information

Authors and Affiliations

  1. The Vice Chancellery, The University of Notre Dame Australia, Fremantle, WA, Australia

    Tanima Dutta & Gregory L. Blatch

  2. The Institute of Immunology and Infectious Diseases, Murdoch University, Murdoch, WA, Australia

    Tanima Dutta & Gregory L. Blatch

  3. College of Health and Biomedicine, Victoria University, Melbourne, VIC, Australia

    Eva-Rachele Pesce

  4. Research School of Biology, The Australian National University, Canberra, Australia

    Alexander G. Maier

  5. Biomedical Biotechnology Research Unit, Department of Biochemistry and Microbiology, Rhodes University, Grahamstown, South Africa

    Gregory L. Blatch

  6. Faculty of Health Sciences, Higher Colleges of Technology, Sharjah, United Arab Emirates

    Gregory L. Blatch

Authors
  1. Tanima Dutta
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  2. Eva-Rachele Pesce
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  3. Alexander G. Maier
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  4. Gregory L. Blatch
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Corresponding author

Correspondence to Gregory L. Blatch .

Editor information

Editors and Affiliations

  1. Department of Biochemistry, University of Venda, Thohoyandou, South Africa

    Addmore Shonhai

  2. Department of Cell Biology, University of Geneva, Genève, Switzerland

    Didier Picard

  3. The Vice Chancellery, The University of Notre Dame Australia, Fremantle, WA, Australia

    Gregory L. Blatch

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Dutta, T., Pesce, ER., Maier, A.G., Blatch, G.L. (2021). Role of the J Domain Protein Family in the Survival and Pathogenesis of Plasmodium falciparum. In: Shonhai, A., Picard, D., Blatch, G.L. (eds) Heat Shock Proteins of Malaria. Advances in Experimental Medicine and Biology, vol 1340. Springer, Cham. https://doi.org/10.1007/978-3-030-78397-6_4

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