Skip to main content
SpringerLink
Log in

Use of Molecular Modeling to Study Spermatogenesis: An Overview Using Proteins in Sertoli Cells

  • Chapter
  • First Online:
Molecular Mechanisms in Spermatogenesis

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1381))

Abstract

Computational structure prediction and analysis helps in understanding the structure and function of varied proteins, which otherwise becomes implausible to understand by experimental procedures. Computational techniques prove to be instrumental in understanding the molecular mechanisms that underlies physiological processes and thereby also assist in identification of potent inhibitors. Spermatogenesis, being an important cellular process that decides the fate of the progeny, holds numerous molecular interaction data, which when identified and visualized with computational structural insights, might yield a cohesive and clear-cut perception to the functionality of several proteins involved. The present chapter deals with a few selected applications of computational structure prediction towards understanding the structure of proteins and highlights how these insights are useful in providing a better understanding of different processes in spermatogenesis.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 139.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 179.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 179.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Similar content being viewed by others

References

  1. Cheng, C. Y., & Mruk, D. D. (2012). Pharmacological Reviews, 64, 16–64.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  2. Wong, E. W., Mruk, D. D., & Cheng, C. Y. (2008). Biochimica et Biophysica Acta, 1778, 692–708.

    Article  CAS  PubMed  Google Scholar 

  3. Wan, H. T., Mruk, D. D., Tang, E. I., Xiao, X., Cheng, Y. H., Wong, E. W., Wong, C. K., & Cheng, C. Y. (2014). Seminars in Cell & Developmental Biology, 30, 65–74.

    Article  CAS  Google Scholar 

  4. Gungor-Ordueri, N. E., Mruk, D. D., Wan, H. T., Wong, E. W., Celik-Ozenci, C., Lie, P. P., & Cheng, C. Y. (2014). Histology and Histopathology, 29, 977–989.

    CAS  PubMed  PubMed Central  Google Scholar 

  5. Cheng, C. Y., & Mruk, D. D. (2011). The Biochemical Journal, 435, 553–562.

    Article  CAS  PubMed  Google Scholar 

  6. Su, W., Mruk, D. D., & Cheng, C. Y. (2013). Critical Reviews in Biochemistry and Molecular Biology, 48, 153–172.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. Tang, E. I., Mruk, D. D., & Cheng, C. Y. (2013). The Journal of Endocrinology, 217, R13–R23.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. Tang, E. I., Xiao, X., Mruk, D. D., Qian, X. J., Mok, K. W., Jenardhanan, P., Lee, W. M., Mathur, P. P., & Cheng, C. Y. (2012). Spermatogenesis, 2, 117–126.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Su, L., Mruk, D. D., & Cheng, C. Y. (2010). Journal of Endocrinology.

    Google Scholar 

  10. Cheng, C. Y., Silvestrini, B., Grima, J., Mo, M. Y., Zhu, L. J., Johansson, E., Saso, L., Leone, M. G., Palmery, M., & Mruk, D. (2001). Biology of Reproduction, 65, 449–461.

    Article  CAS  PubMed  Google Scholar 

  11. Cheng, C. Y., Mo, M., Grima, J., Saso, L., Tita, B., Mruk, D., & Silvestrini, B. (2002). Contraception, 65, 265–268.

    Article  CAS  PubMed  Google Scholar 

  12. Grima, J., Silvestrini, B., & Cheng, C. Y. (2001). Biology of Reproduction, 64, 1500–1508.

    Article  CAS  PubMed  Google Scholar 

  13. Mok, K. W., Mruk, D. D., Lie, P. P., Lui, W. Y., & Cheng, C. Y. (2011). Reproduction, 141, 571–580.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  14. Su, L., Cheng, C. Y., & Mruk, D. D. (2010). The International Journal of Biochemistry & Cell Biology, 42, 1864–1875.

    Article  CAS  Google Scholar 

  15. Kopera, I. A., Su, L., Bilinska, B., Cheng, C. Y., & Mruk, D. D. (2009). Endocrinology, 150, 4724–4733.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  16. Qian, X., Cheng, Y. H., Jenardhanan, P., Mruk, D. D., Mathur, P. P., Xia, W., Silvestrini, B., & Cheng, C. Y. (2013). Spermatogenesis, 3, e24993.

    Article  PubMed  PubMed Central  Google Scholar 

  17. Su, L., Cheng, C. Y., & Mruk, D. D. (2009). The International Journal of Biochemistry & Cell Biology, 41, 2578–2587.

    Article  CAS  Google Scholar 

  18. Li, H., DeRosier, D. J., Nicholson, W. V., Nogales, E., & Downing, K. H. (2002). Structure, 10, 1317–1328.

    Article  CAS  PubMed  Google Scholar 

  19. Raynaud-Messina, B., & Merdes, A. (2007). Current Opinion in Cell Biology, 19, 24–30.

    Article  CAS  PubMed  Google Scholar 

  20. Lie, P. P., Mruk, D. D., Lee, W. M., & Cheng, C. Y. (2010). Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 365, 1581–1592.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  21. Tang, E. I., Mruk, D. D., & Cheng, C. Y. (2016). Seminars in Cell & Developmental Biology, 59, 35–45.

    Article  CAS  Google Scholar 

  22. Hall, E. S., Hall, S. J., & Boekelheide, K. (1995). Fundamental and Applied Toxicology, 24, 173–182.

    Article  CAS  PubMed  Google Scholar 

  23. Russell, L. D., Saxena, N. K., & Turner, T. T. (1989). Tissue & Cell, 21, 361–379.

    Article  CAS  Google Scholar 

  24. Guttman, J. A., Kimel, G. H., & Vogl, A. W. (2000). Journal of Cell Science, 113(Pt 12), 2167–2176.

    Article  CAS  PubMed  Google Scholar 

  25. Tang, E. I., Lee, W. M., & Cheng, C. Y. (2016). Endocrinology, 157, 1644–1659.

    CAS  PubMed  PubMed Central  Google Scholar 

  26. Lowe, J., Li, H., Downing, K. H., & Nogales, E. (2001). Journal of Molecular Biology, 313, 1045–1057.

    Article  CAS  PubMed  Google Scholar 

  27. Dehmelt, L., & Halpain, S. (2005). Genome Biology, 6, 204.

    Article  PubMed  Google Scholar 

  28. Akhmanova, A., & Steinmetz, M. O. (2015). Nature Reviews. Molecular Cell Biology, 16, 711–726.

    Article  CAS  PubMed  Google Scholar 

  29. Panneerselvam, M., Muthu, K., Jayaraman, M., Sridharan, U., Jenardhanan, P., & Ramadas, K. (2013). Molecular BioSystems, 9, 1470–1488.

    Article  CAS  PubMed  Google Scholar 

  30. Trinczek, B., Brajenovic, M., Ebneth, A., & Drewes, G. (2004). Journal of Biological Chemistry, 279, 5915–5923.

    Article  CAS  PubMed  Google Scholar 

  31. Jenardhanan, P., Mannu, J., & Mathur, P. P. (2014). Molecular BioSystems, 10, 1845–1868.

    Article  CAS  PubMed  Google Scholar 

  32. Matenia, D., & Mandelkow, E. M. (2009). Trends in Biochemical Sciences, 34, 332–342.

    Article  CAS  PubMed  Google Scholar 

  33. Marx, A., Nugoor, C., Panneerselvam, S., & Mandelkow, E. (2010). FASEB Journal, 24, 1637–1648.

    Article  CAS  PubMed  Google Scholar 

  34. Rovelet-Lecrux, A., Charbonnier, C., Wallon, D., Nicolas, G., Seaman, M. N. J., Pottier, C., Breusegem, S. Y., Mathur, P. P., Jenardhanan, P., Le Guennec, K., Mukadam, A. S., Quenez, O., Coutant, S., Rousseau, S., Richard, A. C., Boland, A., Deleuze, J. F., Frebourg, T., Hannequin, D., & Campion, D. (2015). Molecular Psychiatry, 20, 1046–1056.

    Article  CAS  PubMed  Google Scholar 

  35. Drewes, G., Ebneth, A., & Mandelkow, E. M. (1998). Trends in Biochemical Sciences, 23, 307–311.

    Article  CAS  PubMed  Google Scholar 

  36. Rovina, D., Fontana, L., Monti, L., Novielli, C., Panini, N., Sirchia, S. M., Erba, E., Magnani, I., & Larizza, L. (2014). European Journal of Cell Biology, 93, 355–365.

    Article  CAS  PubMed  Google Scholar 

  37. Li, N., & Cheng, C. Y. (2016). Histology and Histopathology, 31, 961–968.

    CAS  PubMed  PubMed Central  Google Scholar 

  38. Mok, K. W., Mruk, D. D., & Cheng, C. Y. (2013). International Review of Cell and Molecular Biology, 301, 291–358.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  39. Li, L., & Guan, K. L. (2013). The Journal of Biological Chemistry, 288, 703–708.

    Article  CAS  PubMed  Google Scholar 

  40. Su, L., Mruk, D. D., Lui, W. Y., Lee, W. M., & Cheng, C. Y. (2011). Proceedings of the National Academy of Sciences, 108, 19623–19628.

    Article  CAS  Google Scholar 

  41. Su, L., Jenardhanan, P., Mruk, D. D., Mathur, P. P., Cheng, Y. H., Mok, K. W., Bonanomi, M., Silvestrini, B., & Cheng, C. Y. (2012). Advances in Experimental Medicine and Biology, 763, 318–333.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  42. Cheng, Y. H., Jenardhanan, P., Mathur, P. P., Qian, X., Xia, W., Silvestrini, B., & Cheng, C. Y. (2014). Current Molecular Pharmacology, 7, 147–153.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Centre for Bioinformatics, Pondicherry University, Puducherry, India

    Pranitha Jenardhanan

  2. Department of Biotechnology, BJM School of Biosciences, Indian Institute of Technology Madras, Chennai, India

    Manivel Panneerselvam

  3. Department of Biochemistry & Molecular Biology, School of Life Sciences, Pondicherry University, Puducherry, India

    Premendu P. Mathur

Authors
  1. Pranitha Jenardhanan
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Manivel Panneerselvam
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Premendu P. Mathur
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Sir Run Run Shaw Hospital (SRRSH), Zhejiang University School of Medicine, Hangzhou, Zhejiang, China

    C.Yan Cheng

  2. Sir Run Run Shaw Hospital (SRRSH), Zhejiang University School of Medicine, Hangzhou, Zhejiang, China

    Fei Sun

Rights and permissions

Reprints and permissions

Copyright information

© 2021 The Author(s), under exclusive license to Springer Nature Switzerland AG

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Jenardhanan, P., Panneerselvam, M., Mathur, P.P. (2021). Use of Molecular Modeling to Study Spermatogenesis: An Overview Using Proteins in Sertoli Cells. In: Cheng, C., Sun, F. (eds) Molecular Mechanisms in Spermatogenesis. Advances in Experimental Medicine and Biology, vol 1381. Springer, Cham. https://doi.org/10.1007/978-3-030-77779-1_10

Download citation

Publish with us

Policies and ethics

Search

Navigation