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Neuroglia in Psychiatric Disorders

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Astrocytes in Psychiatric Disorders

Part of the book series: Advances in Neurobiology ((NEUROBIOL,volume 26))

Abstract

In the twentieth century, neuropsychiatric disorders have been perceived solely from a neurone-centric point of view, which considers neurones as the key cellular elements of pathological processes. This dogma has been challenged thanks to the better comprehension of the brain functioning, which, even if far from being complete, has revealed the complexity of interactions that exist between neurones and neuroglia. Glial cells represent a highly heterogeneous population of cells of neural (astroglia and oligodendroglia) and non-neural (microglia) origin populating the central nervous system. The variety of glia reflects the innumerable functions that glial cells perform to support functions of the nervous system. Aberrant execution of glial functions contributes to the development of neuropsychiatric pathologies. Arguably, all types of glial cells are implicated in the neuropathology; however, astrocytes have received particular attention in recent years because of their pleiotropic functions that make them decisive in maintaining cerebral homeostasis. This chapter describes the multiple roles of astrocytes in the healthy central nervous system and discusses the diversity of astroglial responses in neuropsychiatric disorders suggesting that targeting astrocytes may represent an effective therapeutic strategy.

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Acknowledgments

We are grateful to Giorgia Menegoni for her help in preparing the figures.

BL’s work is supported by the National Natural Science Foundation of China (grant number 8187185), LiaoNing Revitalization Talents Program (grant number XLYC1807137), the Scientific Research Foundation for Returned Scholars of Education Ministry of China (grant number 20151098), LiaoNing Thousand Talents Program (grant number 202078), and “ChunHui” Program of Education Ministry of China (grant number 2020703). CS’s work is supported by a grant from the Italian Ministry of Education, University and Research (2015KP7T2Y_002) and a grant from Sapienza University of Rome (RM11916B7A8D0225). VP’s work is supported by a grant from the National Institute of General Medical Sciences of the National Institutes of Health (R01GM123971). VP is an Honorary Professor at University of Rijeka, Croatia.

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Authors and Affiliations

  1. Department of Physiology and Pharmacology “Vittorio Erspamer”, SAPIENZA University of Rome, Rome, Italy

    Caterina Scuderi

  2. Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, UK

    Alexei Verkhratsky

  3. Achucarro Center for Neuroscience, IKERBASQUE, Basque Foundation for Science, Bilbao, Spain

    Alexei Verkhratsky

  4. Department of Neurobiology, The University of Alabama at Birmingham, Birmingham, AL, USA

    Vladimir Parpura

  5. Department of Forensic Analytical Toxicology, School of Forensic Medicine, China Medical University, Shenyang, China

    Baoman Li

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  1. Caterina Scuderi
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  2. Alexei Verkhratsky
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  3. Vladimir Parpura
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  4. Baoman Li
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Correspondence to Caterina Scuderi .

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Editors and Affiliations

  1. Department of Forensic Analytical Toxicology, School of Forensic Medicine, China Medical University, Shenyang, China

    Baoman Li

  2. Department of Neurobiology, The University of Alabama at Birmingham, Birmingham, AL, USA

    Vladimir Parpura

  3. Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK

    Alexei Verkhratsky

  4. Department of Physiology and Pharmacology “Vittorio Erspamer”, Sapienza University of Rome, Rome, Italy

    Caterina Scuderi

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Scuderi, C., Verkhratsky, A., Parpura, V., Li, B. (2021). Neuroglia in Psychiatric Disorders. In: Li, B., Parpura, V., Verkhratsky, A., Scuderi, C. (eds) Astrocytes in Psychiatric Disorders. Advances in Neurobiology, vol 26. Springer, Cham. https://doi.org/10.1007/978-3-030-77375-5_1

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