Skip to main content
SpringerLink
Log in

Biomarkers and Pulmonary Function Test

  • Chapter
  • First Online:
Pulmonary Function Measurement in Noninvasive Ventilatory Support

  • 828 Accesses

Abstract

A biomarker is an objectively measured characteristic that indicates normal or pathological state. Biomarkers of pulmonary function are clinical signs, radiological findings, or laboratory findings that reflect lung functions. In this chapter, we have classified biological markers of pulmonary functions in seven groups as clinical markers, lung volume and pressure markers, radiological markers, lung tissue, blood, sputum, and exhaled breath markers.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 159.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Abbreviations

BMI:

Body mass index

CalvNO:

Alveolar nitric oxide

CC-16:

Club cell protein 16

CCL18:

CC chemokine ligand 18

CO:

Carbon monoxide

COPD:

Chronic obstructive pulmonary disease

CRP:

C-reactive protein

CT:

Computerized tomography

DLCO:

Diffusing capacity for carbon monoxide

DNA:

Deoxyribonucleic acid

EBC:

Exhaled breath condensate

EGFR:

Epidermal growth factor receptor

FEF25–75:

Forced expiratory flow at 25–75% of lung volume

FeNO:

Fractional excretion of nitric oxide

FEV1:

Forced expiratory volume in 1 s

FVC:

Forced vital capacity

GSH-Px:

Glutathione peroxidase

GST:

Glutathione-S-transferase

He:

Helium

HNP:

Human neutrophil peptide

ICAM-1:

Intracellular adhesion molecule-1

ICAM-2:

Intracellular adhesion molecule-2

IGFBP-2:

Insulin-like growth factor-binding protein 2

IL-8:

Interleukin-8

IPF:

Idiopathic pulmonary fibrosis

KL-6:

Krebs von den Lungen-6

MEP:

Maximal expiratory pressure

MIP:

Maximal inspiratory pressure

MMP:

Matrix metalloproteinase

NE:

Neutrophil elastase

PaCO2:

Arterial blood partial pressure of carbon dioxide

PaO2:

Arterial blood partial pressure of oxygen

PFT:

Pulmonary function test

PON1:

Paraoxonase 1

ROS:

Reactive oxygen species

RV:

Residual volume

SOD:

Superoxide dismutase

SP-A:

Surfactant protein A

SP-D:

Surfactant protein D

sRAGE:

Soluble receptor for advanced glycation end products

TLC:

Total lung capacity

TNF-α:

Tumor necrosis factor-α

TOS:

Total oxidative status

VEGF:

Vascular endothelial growth factor

VOCs:

Volatile organic compounds

References

  1. Biomarkers Definitions Working Group. Biomarkers and surrogate endpoints: preferred definitions and conceptual framework. Clin Pharmacol Ther. 2001;69:89–95.

    Article  Google Scholar 

  2. Hollander Z, DeMarco ML, Sadatsafavi M, et al. Biomarker development in COPD. Moving from P values to products to impact patient care. Chest. 2017;151:455–67.

    Article  Google Scholar 

  3. Dempsey T, Scanlon PD. Pulmonary function tests for the generalist: a brief review. Mayo Clin Proc. 2018;93:763–71.

    Article  Google Scholar 

  4. Crossley D, Renton M, Khan M, et al. CT densitometry in emphysema: a systematic review of its clinical utility. Int J Chron Obstruct Pulmon Dis. 2018;13:547–63.

    Article  CAS  Google Scholar 

  5. Cherneva RV, Kostadinov DT. Biomarkers in COPD – challenging, real or illusive. Folia Med. 2018;60:351–63.

    Article  Google Scholar 

  6. Bradford E, Jacobson S, Varasteh J, et al. The value of blood cytokines and chemokines in assessing COPD. Respir Res. 2017;18:180–9.

    Article  Google Scholar 

  7. Mendy A, Forno E, Niyonsenga T, et al. Blood biomarkers as predictors of long-term mortality in COPD. Clin Respir J 2018;12:1891–1899.

    Google Scholar 

  8. Tong X, Wang D, Liu S, et al. The YKL-40 protein is a potential biomarker for COPD: a meta-analysis and systematic review. Int J Chron Obstruct Pulmon Dis. 2018;13:409–18.

    Article  CAS  Google Scholar 

  9. Bafadhel M, Pavord ID, Russell REK. Eosinophils in COPD: just another biomarker? Lancet Respir Med. 2017;5:747–59.

    Article  CAS  Google Scholar 

  10. Zinellu E, Zinellu A, Fois AG, et al. Circulating biomarkers of oxidative stress in chronic obstructive pulmonary disease: a systematic review. Respir Res. 2016;17:150.

    Article  Google Scholar 

  11. Guiot J, Moermans C, Henket M, et al. Blood biomarkers in idiopathic pulmonary fibrosis. Lung. 2017;195:273–80.

    Article  CAS  Google Scholar 

  12. Hayton C, Terrington D, Wilson AM, et al. Breath biomarkers in idiopathic pulmonary fibrosis: a systematic review. Respir Res. 2019;20:7.

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Anesthesiology and Reanimation, Marmara University School of Medicine, Istanbul, Turkey

    Ruslan Abdullayev & Seniyye Ulgen Zengin

Authors
  1. Ruslan Abdullayev
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Seniyye Ulgen Zengin
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Intensive Care Unit, Hospital General Universitario Morales Meseguer, Murcia, Spain

    Antonio M. Esquinas

Rights and permissions

Reprints and permissions

Copyright information

© 2021 The Author(s), under exclusive license to Springer Nature Switzerland AG

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Abdullayev, R., Zengin, S.U. (2021). Biomarkers and Pulmonary Function Test. In: Esquinas, A.M. (eds) Pulmonary Function Measurement in Noninvasive Ventilatory Support. Springer, Cham. https://doi.org/10.1007/978-3-030-76197-4_10

Download citation

  • DOI: https://doi.org/10.1007/978-3-030-76197-4_10

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-76196-7

  • Online ISBN: 978-3-030-76197-4

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics

Search

Navigation