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Subtle Variants of Hyperparathyroidism: Normohormonal Hyperparathyroidism

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Innovations in Modern Endocrine Surgery

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Abstract

The introduction of serum calcium measurement in metabolic and renal panels has increased recognition of normohormonal hyperparathyroidism (NHHPT), the entity in which elevated serum calcium is accompanied by a normal but non-suppressed parathyroid hormone (PTH). Because of its biochemical subtlety, there are important diagnostic and management nuances to consider in approaching this subset of patients, most notably the exclusion of other causes of hypercalcemia. This chapter provides a comprehensive review of NHHPT, including presentation and symptoms, serologic and imaging evaluation, intraoperative challenges, and postoperative considerations. The goal of parathyroid surgery in this cohort is normocalcemia.

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Author information

Authors and Affiliations

  1. Department of Otolaryngology – Head and Neck Surgery, Stanford University School of Medicine, Stanford, CA, USA

    Julia E. Noel & Lisa A. Orloff

  2. Department of Otolaryngology – Head and Neck Surgery, University of Cincinnati College of Medicine, Cincinnati, OH, USA

    David L. Steward

Authors
  1. Julia E. Noel
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  2. David L. Steward
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  3. Lisa A. Orloff
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Correspondence to Lisa A. Orloff .

Editor information

Editors and Affiliations

  1. Department of Otolaryngology – Head and Neck Surgery, Henry Ford Hospital System, Detroit, MI, USA

    Michael C. Singer

  2. Department Otolaryngology and Endocrinology, Augusta University Thyroid and Parathyroid Center, Augusta University, Augusta, GA, USA

    David J. Terris

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Noel, J.E., Steward, D.L., Orloff, L.A. (2021). Subtle Variants of Hyperparathyroidism: Normohormonal Hyperparathyroidism. In: Singer, M.C., Terris, D.J. (eds) Innovations in Modern Endocrine Surgery. Springer, Cham. https://doi.org/10.1007/978-3-030-73951-5_8

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  • DOI: https://doi.org/10.1007/978-3-030-73951-5_8

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-73950-8

  • Online ISBN: 978-3-030-73951-5

  • eBook Packages: MedicineMedicine (R0)

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