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Pharmacological Effects of Natural Components Against Ovarian Cancer and Mechanisms

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Ovarian Cancer: Molecular & Diagnostic Imaging and Treatment Strategies

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1330))

Abstract

Ovarian cancer, one of the three leading malignancies in women, has high incidence and mortality worldwide. It is hard to diagnose until very late stages and the 5-year survival rate is very low, due mostly to its distant metastasis. Chemotherapy is currently the most common treatment to inhibit cancer growth, but long-term use could result in resistance and tumor recurrence in addition to damages to normal tissues and functions of the patients. In order to achieve safe and curative effects against cancers, many investigators have focused their attention on traditional Chinese herbal medicines. Paclitaxel, a natural antitumor agent, has significant effects on advanced malignancies including ovarian cancer and is in the standard front-line treatment. Additional natural anticancer substances have continually been discovered for their high effectiveness and low side-effects in ovarian cancer prevention and therapy. In this chapter, we summarize recent work on a selected group of natural components, including lignans, ellagic acid, luteolin, mangiferin, and Acanthopanax senticosus, which have all been demonstrated to reduce the progress of epithelial ovarian cancer in a dose-depend manner, by both in vitro and in vivo experiments. The mechanisms of the anticancer activities by these natural components involve expression suppression of MMP2 and MMP9.

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Acknowledgments

This work was supported by grants of the National Natural Science Foundation of China (NSFC30970119, 81030029, 81271786, NSFC-NIH 81161120416, 81671980, 81871623) and College students’ Innovation & Entrepreneurship project in Heilongjiang Province (201410226047 J.J.K, D.Y.; 201510226020 D.S.L, L.Y., T.L., L.Q., L.L.G.; 201610226095 H.Y.W., Z.H.S. T.T.G., S.J.H., S.G.; 201610226094 Y.Y.Q., M.Y.; 201710226073 S.J.H., S.G.). H.D.L. is supported by a scholarship from China Scholarship Council, CSC No. 201508230143, for an academic visit to the University of Calgary (Univ. of Calgary ID number: 30016355). We also thank the Health and Family Planning Commission of Heilongjiang Province (2016-188), the Fundamental Research Funds for the Provincial Universities (2017JCZX57), University Nursing Program for Young Scholars with Creative Talents in Heilongjiang Province (UNPYSCT-2018064), the China Postdoctoral Science Foundation (2018M630380), and the Heilongjiang Postdoctoral Financial Assistance (LBH-Z18198) program for their support.

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Authors and Affiliations

  1. Systemomics Center, College of Pharmacy, and Genomics Research Center (State-Province Key Laboratories of Biomedicine-Pharmaceutics of China), Harbin Medical University, Harbin, China

    Huidi Liu & Shu-Lin Liu

  2. HMU-UCCSM Centre for Infection and Genomics, Harbin, China

    Huidi Liu & Shu-Lin Liu

  3. Department of Biochemistry and Molecular Biology, University of Calgary, Calgary, Canada

    Huidi Liu

  4. Department of Microbiology, Immunology and Infectious Diseases, University of Calgary, Calgary, Canada

    Shu-Lin Liu

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  1. Huidi Liu
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  2. Shu-Lin Liu
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Correspondence to Shu-Lin Liu .

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  1. Dept. Veterinary Pathobiology, University of Missouri-Columbia Dept. Veterinary Pathobiology, COLUMBIA, MO, USA

    Heide Schatten

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Liu, H., Liu, SL. (2021). Pharmacological Effects of Natural Components Against Ovarian Cancer and Mechanisms. In: Schatten, H. (eds) Ovarian Cancer: Molecular & Diagnostic Imaging and Treatment Strategies. Advances in Experimental Medicine and Biology, vol 1330. Springer, Cham. https://doi.org/10.1007/978-3-030-73359-9_4

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