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Epitranscriptomics and Diseases

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Epitranscriptomics

Part of the book series: RNA Technologies ((RNATECHN,volume 12))

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Abstract

The role of epitranscriptomics, i.e., RNA base modification, as a component of a “methylome” in disease has emerged as a result of the development of next generation sequencing and other related state-of-art technologies. Epitranscriptomic state is controlled by writing, erasing, and reading methylation, which is mediated by enzymatic reactions. More than 20 methyltransferases have been identified so far. Epitranscriptomic mechanisms are involved in the development of diseases such as cancer of mice and humans. In this review article, we discuss recent developments in epitranscriptomics for the further application of epitranscriptomic knowledge for use as diagnostic tools and therapeutic approaches.

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Acknowledgments

We wish to thank the members of our laboratories. This work was supported in part by a Grant-in-Aid for Scientific Research from the Ministry of Education, Culture, Sports, Science, and Technology (17H04282, 17K19698, 18K16356, and 18K16355); and Japan Agency for Medical Research and Development (AMED) (16cm0106414h0001 and 17cm0106414h0002). Partial support was received from the Princess Takamatsu Cancer Research Fund. Partial institutional endowments were received from Hirotsu Bio Science Inc. (Tokyo, Japan); Kinshu-kai Medical Corporation (Osaka, Japan); Kyowa-kai Medical Corporation (Osaka, Japan); IDEA Consultants Inc. (Tokyo, Japan); and Unitech Co. Ltd. (Chiba, Japan).

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  1. Osaka University Graduate School of Medicine, Center of Medical Innovation and Translational Research, Osaka, Japan

    Masamitsu Konno & Hideshi Ishii

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  1. Masamitsu Konno
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  2. Hideshi Ishii
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Correspondence to Hideshi Ishii .

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  1. Nanobiomedical Center, Adam Mickiewicz University, Poznań, Poland

    Stefan Jurga

  2. Nanobiomedical Center of the Adam Mickiewicz University, Poznań and, Institute of Bioorganic Chemistry of the Polish Academy of Sciences, Poznań, Poland

    Jan Barciszewski

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Konno, M., Ishii, H. (2021). Epitranscriptomics and Diseases. In: Jurga, S., Barciszewski, J. (eds) Epitranscriptomics. RNA Technologies, vol 12. Springer, Cham. https://doi.org/10.1007/978-3-030-71612-7_4

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