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Differences in Respiratory Mechanics in Emphysema and Chronic Bronchitis Evaluated by Forced Oscillations

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XXVII Brazilian Congress on Biomedical Engineering (CBEB 2020)

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Abstract

Chronic obstructive pulmonary disease (COPD) includes emphysema and chronic bronchitis. These different phenotypes may introduce different characteristics that need to be known to improve COPD treatment. Thus, the objective of this study is to identify through the forced oscillations technique (FOT) the differences in respiratory mechanics in these phenotypes before and after bronchodilator (BD) use. In this cross-sectional study, the results of a sample of 30 volunteers are presented, being divided into control group (CG = 10), emphysema (ENF = 10) and chronic bronchitis (CB = 10). Spirometric and plethysmographic exams were also performed. Before BD, resistances were higher in CB than in controls, a fact that did not occur in a similar comparison in patients with ENF. It were observed increased resistances and impedance modulus in CB in comparison with ENF after BD use, which may be explained by secretion mobilization due to maximum expiratory effort during spirometry. These results provide evidence that the presence of CB results in greater respiratory work than that resulting from the presence of ENF. This new information on COPD phenotypes can contribute to improving the therapeutic strategies used, and consequently, to the assistance offered to these patients. The presented results also provide evidence that FOT is a useful tool in evaluation of the COPD phenotypes, adequately describing the disease’s physiology and clinical practice.

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References

  1. Oliveira PC (2013) Clinical presentations of COPD. Pulmão RJ 22(2):15–18

    Google Scholar 

  2. Murray CJ, Lopez AD (1997) Alternative projections of mortality and disability by cause 1990–2020: global burden of disease study. Lancet 349(9064):1498–1504

    Article  Google Scholar 

  3. Leung JM, Obeidat M, Sadatsafavi M, Sin DD (2019) Introduction to precision medicine in COPD. Eur Respir J

    Google Scholar 

  4. Izquierdo-Alonso JL, Rodriguez-Gonzalezmoro JM, de Lucas-Ramos P, Unzueta I, Ribera X, Anton E, Martin A (2013) Prevalence and characteristics of three clinical phenotypes of chronic obstructive pulmonary disease (COPD). Respir Med 107(5):724–731

    Article  Google Scholar 

  5. Miravitlles M, Soler-Cataluña JJ, Calle M, Molina J, Almagro P, Quintano JA, Trigueros JA, Cosío BG, Casanova C, Antonio Riesco J et al (2017) Spanish guidelines for management of chronic obstructive pulmonary disease (GesEPOC) 2017. Pharmacological treatment of stable phase. Arch Bronconeumol 53(6):324–335

    Google Scholar 

  6. Cheng Y, Tu X, Pan L, Lu S, Xing M, Li L, Chen X (2017) Clinical characteristics of chronic bronchitic, emphysematous and ACOS phenotypes in COPD patients with frequent exacerbations. Int J Chron Obstruct Pulmon Dis 12:2069–2074

    Article  Google Scholar 

  7. Koblizek V, Chlumsky J, Zindr V, Neumannova K, Zatloukal J, Zak J, Sedlak V, Kocianova J, Hejduk K, Pracharova S (2013) Chronic obstructive pulmonary disease: official diagnosis and treatment guidelines of the czech pneumological and phthisiological society; a novel phenotypic approach to COPD with patient-oriented care. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 157(2):189–201

    Article  Google Scholar 

  8. Calle Rubio M, Casamor R, Miravitlles M (2017) Identification and distribution of COPD phenotypes in clinical practice according to Spanish COPD guidelines: the FENEPOC study. Int J Chron Obstruct Pulmon Dis 12:2373–2383

    Article  Google Scholar 

  9. Trindade AM, Sousa TLF, Albuquerque ALP (2015) The interpretation of spirometry on pulmonary care: until where can we go with the use of its parameters? Revista Pulmão RJ 24(1):3–7

    Google Scholar 

  10. Qi GS, Zhou ZC, Gu WC, Xi F, Wu H, Yang WL, Liu JM (2013) Detection of the airway obstruction stage in asthma using impulse oscillometry system. J Asthma 50

    Google Scholar 

  11. Pereira CAC, Moreira MAF (2002) Pletismografia—resistência das vias aéreas. J Pneumologia 28:139–150

    Google Scholar 

  12. King GG, Bates J, Berger KI, Calverley P, de Melo PL, Dellaca RL, Farre R, Hall GL, Ioan I, Irvin CG et al (2019) Technical standards for respiratory oscillometry. Eur Respir J

    Google Scholar 

  13. Dubois AB, Brody AW, Lewis DH, Burgess BF Jr (1956) Oscillation mechanics of lungs and chest in man. J Appl Physiol 8(6):587–594

    Article  Google Scholar 

  14. Ribeiro CO, Faria ACD, Lopes AJ, Melo PL (2018) Forced oscillation technique for early detection of the effects of smoking and COPD: contribution of fractional-order modeling. Int J Chronic Obstructive Pulm Dis 13:3281–3295

    Article  Google Scholar 

  15. Kaczka DW, Dellacá RL (2011) Oscillation mechanics of the respiratory system: applications to lung disease. Crit Rev Biomed Eng 39(4):337–359

    Article  Google Scholar 

  16. King GG (2011) Cutting edge technologies in respiratory research: lung function testing. Respirology 16(6):883–890

    Article  Google Scholar 

  17. Ribeiro CO, Faria AC, Lopes AJ, Melo PL (2018) Forced oscillation technique for early detection of the effects of smoking and chronic obstructive pulmonary disease: contribution of fractional-order modeling. Int J COPD 13:3281–3295

    Article  Google Scholar 

  18. Faria ACD, Dames da Silva KK, Costa GM, Lopes AJ, Melo PL (2012) Forced oscillation technique in the detection of smoking-induced respiratory changes. In: Hudak R, Penhaker M, Majernik J (eds) Biomedical engineering—technical applications in medicine vol 1. InTech, Croatia

    Google Scholar 

  19. Melo PLd, Werneck MM, Giannella-Neto A (2000) New impedance spectrometer for scientific and clinical studies of the respiratory system

    Google Scholar 

  20. Miranda IA, Dias Faria AC, Lopes AJ, Jansen JM, Lopes de Melo P (2013) On the respiratory mechanics measured by forced oscillation technique in patients with systemic sclerosis. PLoS ONE 8(4):

    Article  Google Scholar 

  21. Navajas D, Farre R (2001) Forced oscillation technique: from theory to clinical applications. Monaldi archives for chest disease = Archivio Monaldi per le malattie del torace/Fondazione clinica del lavoro, IRCCS [and] Istituto di clinica tisiologica e malattie apparato respiratorio, Universita di Napoli, Secondo ateneo 56(6):555–562

    Google Scholar 

  22. Cataluña JJS, Cosio B, Izquierdo JL, Campos JLL, Marin JM, Aguero R, Baloira A, Carrizo S, Esteban C, Galdiz JB et al (2012) Documento de consenso sobre o fenótipo de asma-COPD misto no Documento de Consenso da DPOC sobre o Fenótipo de Sobreposição COPD-Asma na DPOC. Archivos de Bronconeumologia 48(9):331–337

    Google Scholar 

  23. Bártholo TP, da Costa CH (2017) Fenótipos da DPOC: há interesse prático nesta avaliação? COPD phenotypes: is it interesting in clinical practice? Revista Pulmão 26:23–28

    Google Scholar 

  24. Global Initiative For Chronic Obstructive Lung Disease—UPDATE (2019) Global strategy for the diagnosis, management, and prevention of chronic obstrutive pulmonary disease

    Google Scholar 

  25. Pereira CAC, Sato T, Rodrigues SC (2007) Novos valores de referência para espirometria forçada em brasileiros adultos de raça branca. J Brasileiro Pneumologia 33

    Google Scholar 

  26. Neder JA, Andreoni S, Lerario MC, Nery L (1999) Valores de referência para testes de função pulmonar. II. Pressões respiratórias máximas e ventilação voluntária. Revista Brasileira de Pesquisa Médica e Biológica 32(0100-879X)

    Google Scholar 

  27. Singh D, Agusti A, Anzueto A, Barnes PJ, Bourbeau J, Celli BR, Criner GJ, Frith P, Halpin DMG, Han M et al (2019) Global strategy for the diagnosis, management, and prevention of chronic obstructive lung disease: the GOLD science committee report. Eur Respir J

    Google Scholar 

  28. Di Mango AM, Lopes AJ, Jansen JM, Melo PL (2006) Changes in respiratory mechanics with increasing degrees of airway obstruction in COPD: detection by forced oscillation technique. Respir Med 100(3):399–410

    Article  Google Scholar 

  29. Cavalcanti JV, Lopes AJ, Jansen JM, Melo PL (2006) Detection of changes in respiratory mechanics due to increasing degrees of airway obstruction in asthma by the forced oscillation technique. Respir Med 100(12):2207–2219

    Article  Google Scholar 

  30. Cavalcanti JA, Lopes AJ, Jansen JM, Melo PL (2006) Técnica de oscilações forçadas na análise da resposta broncodilatadora em voluntários sadios e indivíduos portadores de asma brônquica com resposta positiva. J Brasileiro de Paneumologia 91–98

    Google Scholar 

  31. Johannessen A, Lehmann S, Omenaas ER, Eide GE, Bakke PS, Gulsvik A (2006) Post-bronchodilator spirometry reference values in adults and implications for disease management. Am J Respir Crit Care Med 173(12):1316–1325

    Article  Google Scholar 

  32. Ribeiro FCV, Lopes AJ, Melo PL (2018) Reference values for respiratory impedance measured by the forced oscillation technique in adult men and women. Clin Respir J 12(6):2126–2135

    Article  Google Scholar 

  33. Fujimoto K, Kitaguchi Y, Kanda S, Urushihata K, Hanaoka M, Kubo K (2011) Comparison of efficacy of long-acting bronchodilators in emphysema dominant and emphysema nondominant chronic obstructive pulmonary disease. Int J Chron Obstruct Pulmon Dis 6:219–227

    Article  Google Scholar 

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Author information

Authors and Affiliations

  1. Biomedical Instrumentation Laboratory, Institute of Biology and Faculty of Engineering, State University of Rio de Janeiro, Vila Isabel, Rio de Janeiro, Brazil

    E. M. Teixeira & P. L. Melo

  2. Pulmonary Function Laboratory, State University of Rio de Janeiro, Pedro Ernesto University Hospital, Rio de Janeiro, Brazil

    A. J. Lopes

  3. Laboratory of Clinical and Experimental, Research in Vascular Biology, State University of Rio de Janeiro, Rio de Janeiro, Brazil

    P. L. Melo

Authors
  1. E. M. Teixeira
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  2. A. J. Lopes
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  3. P. L. Melo
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Corresponding author

Correspondence to P. L. Melo .

Editor information

Editors and Affiliations

  1. Department of Electrical Engineering, Universidade Federal do Espírito Santo, Vitória, Brazil

    Teodiano Freire Bastos-Filho

  2. Department of Electrical Engineering, Universidade Federal do Espírito Santo, Vitória, Brazil

    Eliete Maria de Oliveira Caldeira

  3. Department of Electrical Engineering, Universidade Federal do Espírito Santo, Vitória, Brazil

    Anselmo Frizera-Neto

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Teixeira, E.M., Lopes, A.J., Melo, P.L. (2022). Differences in Respiratory Mechanics in Emphysema and Chronic Bronchitis Evaluated by Forced Oscillations. In: Bastos-Filho, T.F., de Oliveira Caldeira, E.M., Frizera-Neto, A. (eds) XXVII Brazilian Congress on Biomedical Engineering. CBEB 2020. IFMBE Proceedings, vol 83. Springer, Cham. https://doi.org/10.1007/978-3-030-70601-2_44

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  • DOI: https://doi.org/10.1007/978-3-030-70601-2_44

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-70600-5

  • Online ISBN: 978-3-030-70601-2

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