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Semaphorin3E/plexinD1 Axis in Asthma: What We Know So Far!

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Lung Inflammation in Health and Disease, Volume II

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1304))

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Abstract

Semaphorin3E belongs to the large family of semaphorin proteins. Semaphorin3E was initially identified as axon guidance cues in the neural system. It is universally expressed beyond the nervous system and contributes to regulating essential cell functions such as cell migration, proliferation, and adhesion. Binding of semaphorin3E to its receptor, plexinD1, triggers diverse signaling pathways involved in the pathogenesis of various diseases from cancer to autoimmune and allergic disorders. Here, we highlight the novel findings on the role of semaphorin3E in airway biology. In particular, we highlight our recent findings on the function and potential mechanisms by which semaphorin3E and its receptor, plexinD1, impact airway inflammation, airway hyperresponsiveness, and remodeling in the context of asthma.

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Acknowledgments

This work was supported by the Canadian Institutes of Health Research grant (MOP # 115115) and the Research Manitoba Chair to A. S. G.

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Authors and Affiliations

  1. Department of Immunology, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB, Canada

    Latifa Koussih & Abdelilah S. Gounni

  2. Department des sciences experimentales, Universite de Saint Boniface, Winnipeg, Manitoba, Canada

    Latifa Koussih

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  1. Latifa Koussih
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  2. Abdelilah S. Gounni
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Correspondence to Abdelilah S. Gounni .

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  1. Department of Molecular & Cellular Physiology, Albany Medical College, Albany, NY, USA

    Yong-Xiao Wang

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Koussih, L., Gounni, A.S. (2021). Semaphorin3E/plexinD1 Axis in Asthma: What We Know So Far!. In: Wang, YX. (eds) Lung Inflammation in Health and Disease, Volume II. Advances in Experimental Medicine and Biology, vol 1304. Springer, Cham. https://doi.org/10.1007/978-3-030-68748-9_12

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