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Sema4A and Chronic Inflammation

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Chronic Inflammation

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Abstract

Semaphorins were originally identified as axon guidance factors involved in the development of the nervous system. However, accumulating evidence indicates that several semaphorins, so-called ‘immune semaphorins’, have important functions in various phases of pathological and physiological immune responses, such as cell–cell interactions, immune-cell activation, differentiation, and trafficking/migration. For example, Sema4A, a class IV transmembrane semaphorin, plays crucial roles in dendritic cells, macrophages, and T cells. In addition, Sema4A is involved in various chronic inflammatory diseases including multiple sclerosis, asthma/allergic rhinitis/ atopic dermatitis, and retinitis pigmentosa.

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Authors and Affiliations

  1. Department of Respiratory Medicine, Allergy and Rheumatic Disease, Osaka University Graduate School of Medicine, Suita, Osaka, Japan

    Daisuke Ito

  2. AMED-CREST, Suita, Osaka, Japan

    Atsushi Kumanogoh

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  1. Daisuke Ito
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  2. Atsushi Kumanogoh
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Correspondence to Atsushi Kumanogoh .

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Editors and Affiliations

  1. Interdisciplinary Program for Biomedical Sciences Institute for Academic Initiatives, Osaka University, Suita, Japan

    Masayuki Miyasaka

  2. Department of Immunobiology and Pharmacological Genetics Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama, Japan

    Kiyoshi Takatsu

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Ito, D., Kumanogoh, A. (2016). Sema4A and Chronic Inflammation. In: Miyasaka, M., Takatsu, K. (eds) Chronic Inflammation. Springer, Tokyo. https://doi.org/10.1007/978-4-431-56068-5_3

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