Abstract
Surface Enhanced Raman Spectroscopy (SERS) takes the advantages of strongly increased signal of Raman scattering generated by local field enhancements near metallic nanostructures. The internal modes of the reporter molecule can be used for monitoring the signal, and appropriate placement of the reporter molecule on the metal nanoparticle surface is a well-appreciated challenge. Several approaches have been suggested for this purpose, and multipurpose functionalized hybrid nanoparticles are very promising for the detection of trace amounts of analyte. Simple and fast generation of nanoparticles and their modification with appropriate probe pave the way for new SERS applications.
Rapid and sensitive detection of trace amounts of analyte remain a challenge in numerous areas such as food industry, medical diagnosis, biodefence, and drug analysis. This chapter underlines the SERS-based, fast, sensitive, and selective biosensor applications regarding the most preferred surface preparation techniques. The latest labeled and label-free applications of Raman spectroscopy in biology and especially recent contributions to the biosensors are the main topics of this chapter. In addition, optimization strategies and the analytical performance of the SERS-based assays are presented in the scope of this chapter.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Similar content being viewed by others
References
Akin MS, Yilmaz M, Babur E et al (2014) Large area uniform deposition of silver nanoparticles through bio-inspired polydopamine coating on silicon nanowire arrays for practical SERS applications. J Mater Chem B 2:4894–4900. https://doi.org/10.1039/c4tb00616j
Albrecht MG, Creighton JA (1977) Anomalously intense Raman-spectra of pyridine at a silver electrode. J ACS 99:5215–5217
Al-Ogaidi I, Gou H, Al-kazaza AKA et al (2014) A gold@silica core–shell nanoparticle-based surface-enhanced Raman scattering biosensor for label-free glucose detection. Anal Chim Acta 811:76–80. https://doi.org/10.1016/j.aca.2013.12.009
Anema JR, Brolo AG, Marthandam P, Gordon R (2008) Enhanced Raman scattering from nanoholes in a copper film. J Phys Chem C 112:17051–17055. https://doi.org/10.1021/jp805785s
Baniukevic J, Boyaci IH, Bozkurt AG et al (2013) Magnetic gold nanoparticles in SERS-based sandwich immunoassay for antigen detection by well oriented antibodies. Biosens Bioelectron 43:281–288. https://doi.org/10.1016/j.bios.2012.12.014
Barhoumi A, Halas NJ (2010) Label-free detection of DNA hybridization using surface enhanced Raman spectroscopy. J Am Chem Soc 132:12792–12793. https://doi.org/10.1021/ja105678z
Bell SEJ, Sirimuthu NMS (2006) Surface-enhanced Raman spectroscopy (SERS) for sub-micromolar detection of DNA RNA mononucleotides. J Am Chem Soc 128:15580–15581. https://doi.org/10.1021/ja066263w
Berger M, Gray JA, Roth BL (2009) The expanded biology of serotonin. Annu Rev Med 60:355–366. https://doi.org/10.1146/annurev.med.60.042307.110802
Bi L, Rao Y, Tao Q et al (2013) Fabrication of large-scale gold nanoplate films as highly active SERS substrates for label-free DNA detection. Biosens Bioelectron 43:193–199
Bowden M, Song L, Walt DR (2005) Development of a microfluidic platform with an optical imaging microarray capable of attomolar target DNA detection. Anal Chem 77:5583–5588
Cai H, Huang B, Lin R et al (2018) A ‘“turn-off”’ SERS assay for kinase detection based on arginine N-phosphorylation process. Talanta 189:353–358
Campion A, Kambhampati P (1998) Surface-enhanced Raman scattering. Chem Soc Rev 27:241–250
Chen L, Mungroo N, Daikuara L, Neethirajan S (2015) Label-free NIR-SERS discrimination and detection of foodborne bacteria by in situ synthesis of Ag colloids. J Nanobiotechnol 13:1–9. https://doi.org/10.1186/s12951-015-0106-4
Cheong Y, Kim YJ, Kang H et al (2017) Rapid label-free identification of Klebsiella pneumoniae antibiotic resistant strains by the drop-coating deposition surface-enhanced Raman scattering method. Spectrochim Acta Part A Mol Biomol Spectrosc 183:53–59. https://doi.org/10.1016/j.saa.2017.04.044
Cho S-J, Idrobo J-C, Olamit J et al (2005) Growth mechanisms and oxidation resistance of gold-coated iron nanoparticles. Chem Mater 17:3181–3186. https://doi.org/10.1021/cm0500713
Choi N, Lee K, Lim DW et al (2012) Simultaneous detection of duplex DNA oligonucleotides using a SERS-based micro-network gradient chip. Lab Chip 12:5160–5167. https://doi.org/10.1039/c2lc40890bWe
Chon H, Lee S, Yoon S-Y et al (2011) Simultaneous immunoassay for the detection of two lung cancer markers using functionalized SERS nanoprobes. Chem Commun 47:12515–12517. https://doi.org/10.1039/C1CC15707h
Chon H, Lee S, Wang R et al (2014a) SERS-based immunoassay of anti-cyclic citrullinated peptide for early diagnosis of rheumatoid arthritis. RSC Adv 4:32924–32927. https://doi.org/10.1039/c4ra05149a
Chon H, Lee S, Yoon S-Y et al (2014b) SERS-based competitive immunoassay of troponin I and CK-MB markers for early diagnosis of acute myocardial infarction. Chem Commun 50:1058–1060. https://doi.org/10.1039/c3cc47850e
Combs ZA, Chang S, Clark T et al (2011) Label-free Raman mapping of surface distribution of protein A and IgG biomolecules. Langmuir 27:3198–3205. https://doi.org/10.1021/la104787w
Cozar IB, Colniţă A, Szöke-Nagy T et al (2019) Label-free detection of bacteria using surface-enhanced Raman scattering and principal component analysis. Anal Lett 52:177–189. https://doi.org/10.1080/00032719.2018.1445747
Culha M (2013) Surface-enhanced Raman free detection and identification scattering: an emerging label-technique for proteins. Appl Spectrosc OA 67:355–364. https://doi.org/10.1366/12-06895
Das G, Patra N, Gopalakrishanan A et al (2012) Surface enhanced Raman scattering substrate based on gold-coated anodic porous alumina template. Microelectron Eng 97:383–386. https://doi.org/10.1016/j.mee.2012.02.037
De Angelis F, Patrini M, Das G et al (2008) A hybrid plasmonic-photonic nanodevice for label-free detection of a few molecules. Nano Lett 8:2321–2327. https://doi.org/10.1021/nl801112e
Delong L, Danfeng L, Qiao Z et al (2015) Large-area high-performance SERS substrates prepared with a combination of mesoporous silica film and AuAg alloy film. Acta Chim Sin 73:41–46
Demirel G, Tamer U (2012) Isotropic and anisotropic dipeptide films based on gas phase deposition. Nanotechnology 23:1–6. https://doi.org/10.1088/0957-4484/23/22/225604
Deng YL, Juang YJ (2014) Black silicon SERS substrate: effect of surface morphology on SERS detection and application of single algal cell analysis. Biosens Bioelectron 53:37–42. https://doi.org/10.1016/j.bios.2013.09.032
Dong O, Lam DCC (2011) Silver nanoparticles as surface-enhanced Raman substrate for quantitative identification of label-free proteins. Mater Chem Phys 126:91–96. https://doi.org/10.1016/j.matchemphys.2010.12.005
Dong J, Chen Y, Guo M et al (2015) Effective hotspot arrays based on non-close-packed gold nanoshells in microporous polystyrene film on acupuncture needles. J Nanosci Nanotechnol 15:3987–3993
Driskell JD, Tripp RA (2010) Label-free SERS detection of microRNA based on affinity for an unmodified silver nanorod array substrate. Chem Commun 46:3298–3300. https://doi.org/10.1039/c002059a
Duan N, Chang B, Zhang H et al (2016) Salmonella typhimurium detection using a surface-enhanced Raman scattering-based aptasensor. Int J Food Microbiol 218:38–43. https://doi.org/10.1016/j.ijfoodmicro.2015.11.006
Dutta RK, Sharma PK, Pandey AC (2009) Surface enhanced Raman spectra of Escherichia coli cells using Zno nanoparticles. Dig J Nanomater Biostruct 4:83–87
El-Said WA, Fouad DM, El-Safty SA (2016) Ultrasensitive label-free detection of cardiac biomarker myoglobin based on surface-enhanced Raman spectroscopy. Sensors Actuators B Chem 228:401–409. https://doi.org/10.1016/j.snb.2016.01.041
Fabris L, Dante M, Nguyen TQ et al (2008) SERS aptatags: new responsive metallic nanostructures for heterogeneous protein detection by surface enhanced Raman spectroscopy. Adv Funct Mater 18:2518–2525
Ferguson BS, Buchsbaum SF, Swensen JS et al (2009) Integrated microfluidic electrochemical DNA sensor. Anal Chem 81:6503–6508. https://doi.org/10.1021/ac900923e
Fleischmann M, Hendra PJ, McQuillan AJ (1974) Raman spectra of pyridine adsorbed at a silver electrode. Chem Phys Lett 26:163–166
Foultier B, Moreno-Hagelsieb L, Flandre D, Remacle J (2005) Comparison of DNA detection methods using nanoparticles and silver enhancement. IEE Proc Nanobiotechnol 152:3–12. https://doi.org/10.1049/ip-nbt:20055017
Fu J, Park B, Zhao Y (2009) Limitation of a localized surface plasmon resonance sensor for Salmonella detection. Sensors Actuators B Chem 141:276–283. https://doi.org/10.1016/j.snb.2009.06.020
Gao R, Cheng Z, DeMello AJ, Choo J (2016) Wash-free magnetic immunoassay of the PSA cancer marker using SERS and droplet microfluidics. Lab Chip 16:1022–1029. https://doi.org/10.1039/c5lc01249j
Gerardo P, Candeloro P, Gentile F et al (2015) A microfluidic dialysis device for complex biological mixture SERS analysis. Microelectron Eng 144:37–41. https://doi.org/10.1016/j.mee.2015.02.015
Germain V, Brioude A, Ingert D, Pileni MP (2005) Silver nanodisks: size selection via centrifugation and optical properties. J Chem Phys 122:1–8. https://doi.org/10.1063/1.2734550
Gupta VK, Atar N, Yola ML et al (2013) A novel glucose biosensor platform based on Ag@AuNPs modified graphene oxide nanocomposite and SERS application. J Colloid Interface Sci 406:231–237. https://doi.org/10.1016/j.jcis.2013.06.007
Hatab NA, Hsueh C-H, Gaddis AL et al (2010) Free-standing optical gold bowtie nanoantenna with variable gap size for enhanced Raman spectroscopy. Nano Lett 10:4952–4955. https://doi.org/10.1021/nl102963g
He L, Langlet M, Bouvier P et al (2014) New insights into surface-enhanced Raman spectroscopy label-free detection of DNA on Ag°/TiO2 substrate. J Phys Chem C 118:25658–25670. https://doi.org/10.1021/jp507462y
Huang Z, Zhang R, Chen H et al (2019) Sensitive polydopamine bi-functionalized SERS immunoassay for microalbuminuria detection. Biosens Bioelectron 142:1–6. https://doi.org/10.1016/j.bios.2019.111542
Hughes J, Izake EL, Lott WB et al (2014) Ultra sensitive label free surface enhanced Raman spectroscopy method for the detection of biomolecules. Talanta 130:20–25. https://doi.org/10.1016/j.talanta.2014.06.012
Hunter R, Sohi AN, Khatoon Z et al (2019) Optofluidic label-free SERS platform for rapid bacteria detection in serum. Sensors Actuators B Chem 300:1–9. https://doi.org/10.1016/j.snb.2019.126907
Hwang J, Lee S, Choo J (2016) Application of a SERS-based lateral flow immunoassay strip for the rapid and sensitive detection of staphylococcal enterotoxin B. Nanoscale 8:11418–11425. https://doi.org/10.1039/c5nr07243c
Jain PK, Huang X, El-Sayed IH, El-Sayed MA (2007) Review of some interesting surface plasmon resonance-enhanced properties of Noble metal nanoparticles and their applications to biosystems. Plasmonics 2:107–118. https://doi.org/10.1007/s11468-007-9031-1
Jeanmaire DL, Van Duyne RP (1977) Surface raman spectroelectrochemistry. 1. Heterocyclic, aromatic, and aliphatic-amines adsorbed on anodized silver electrode. J Electroanal Chem Interfacial Electrochem 84:1–20
Ji W, Kitahama Y, Han X et al (2012) pH-dependent SERS by semiconductor-controlled charge-transfer contribution. J Phys Chem C 116:24829–24836. https://doi.org/10.1021/jp308805n
Joseph MM, Nair JB, Maiti KK, Sreelekha Therakathinal T (2017) Plasmonically enhanced galactoxyloglucan endowed gold nanoparticles exposed tumor targeting biodistribution envisaged in a surface-enhanced Raman scattering platform. Biomacromolecules 18:4041–4053. https://doi.org/10.1021/acs.biomac.7b01109
Kadam US, Schulz B, Lrudayaraj J (2014) Detection and quantification of alternative splice sites in Arabidopsis genes AtDCL2 and AtPTB2 with highly sensitive surface enhanced Raman spectroscopy (SERS) and gold nanoprobes. FEBS Lett 588:1637–1643. https://doi.org/10.1016/j.febslet.2014.02.061
Kahraman M, Wachsmann-Hogiu S (2015) Label-free and direct protein detection on 3D plasmonic nanovoid structures using surface-enhanced Raman scattering. Anal Chim Acta 856:74–81. https://doi.org/10.1016/j.aca.2014.11.019
Kamińska A, Witkowska E, Winkler K et al (2015) Detection of hepatitis B virus antigen from human blood: SERS immunoassay in a microfluidic system. Biosens Bioelectron 66:461–467. https://doi.org/10.1016/j.bios.2014.10.082
Kaminska A, Witkowska E, Kowalska A et al (2016) Rapid detection and identification of bacterial meningitis pathogens in ex vivo clinical samples by SERS method and principal component analysis. Anal Methods 8:4521–4529. https://doi.org/10.1039/c6ay01018k
Kang B, Austin LA, El-Sayed MA (2012) Real-time molecular imaging throughout the entire cell cycle by targeted plasmonic-enhanced Rayleigh/Raman spectroscopy. Nano Lett 12:5369–5375. https://doi.org/10.1021/nl3027586
Kayran YU, Jambrec D, Schuhmann W (2019) Nanostructured DNA microarrays for dual SERS and electrochemical read-out. Electroanalysis 31:267–272. https://doi.org/10.1002/elan.201800579
Kneipp K, Wang Y, Kneipp H et al (1997) Single molecule detection using surface-enhanced Raman scattering (SERS). Phys Rev Lett 78:1667–1670. https://doi.org/10.1103/PhysRevLett.78.1667
Kneipp K, Kneipp H, Deinum G et al (1998a) Single-molecule detection of a cyanine dye in silver colloidal solution using near-infrared surface-enhanced Raman scattering. Appl Spectrosc 52:175–178
Kneipp K, Kneipp H, Kartha VB et al (1998b) Detection and identification of a single DNA base molecule using surface-enhanced Raman scattering (SERS). Rapid Commun 57:6281–6284. https://doi.org/10.1103/PhysRevE.57.R6281
Kneipp K, Kneipp H, Manoharan R et al (1998c) Near-infrared surface-enhanced Raman scattering can detect single molecules and observe “hot” vibrational transitions. J Raman Spectrosc 29:743–747. https://doi.org/10.1002/(SICI)1097-4555(199808)29:8%3C743:AID-JRS294%3E3.0.CO;2-M/98/080743-05
Kneipp K, Kneipp H, Itzkan I et al (1999) Surface-enhanced non-linear Raman scattering at the single-molecule level. Chem Phys 247:155–162
Kong K, Rowlands CJ, Elsheikha H, Notingher I (2012) Label-free molecular analysis of live Neospora caninum tachyzoites in host cells by selective scanning Raman micro-spectroscopy. Analyst 137:4119–4122. https://doi.org/10.1039/c2an35640f
Kong KV, Leong WK, Lam Z et al (2014) A rapid and label-free SERS detection method for biomarkers in clinical biofluids. Small 10:5030–5034. https://doi.org/10.1002/smll.201401713
Konry T, Hayman RB, Walt DR (2009) Microsphere-based rolling circle amplification microarray for the detection of DNA and proteins in a single assay. Anal Chem 81:5777–5782. https://doi.org/10.1021/ac900694y
Kubus L, Erdogan H, Piskin E, Demirel G (2012) Controlling uni directional wetting via surface chemistry and morphology. Soft Matter 8:11704–11707. https://doi.org/10.1039/c2sm26619a
Le Ru EC, Blackie E, Meyer M, Etchegoin PG (2007) Surface enhanced Raman scattering enhancement factors: a comprehensive study. J Phys Chem C 111:13794–13803. https://doi.org/10.1021/jp0687908
Lee S, Mayer KM, Hafner JH (2009) Improved localized surface plasmon resonance immunoassay with gold bipyramid substrates. Anal Chem 81:4450–4455. https://doi.org/10.1021/ac900276n
Lee M, Lee K, Kim KH et al (2012) SERS-based immunoassay using a gold array-embedded gradient microfluidic chip. Lab Chip 12:3720–3727. https://doi.org/10.1039/c2lc40353f
Li M, Cushing SK, Zhang J et al (2013a) Three-dimensional hierarchical plasmonic nano-architecture enhanced surface-enhanced Raman scattering immunosensor for cancer biomarker detection in blood plasma. ACS Nano 7:4967–4976. https://doi.org/10.1021/nn4018284
Li W, Zamani R, Rivera Gil P et al (2013b) CuTe nanocrystals: shape and size control, plasmonic properties, and use as SERS probes and photothermal agents. J Am Chem Soc 135:7098–7101. https://doi.org/10.1021/ja401428e
Li YT, Li DW, Cao Y, Long YT (2015) Label-free in-situ monitoring of protein tyrosine nitration in blood by surface-enhanced Raman spectroscopy. Biosens Bioelectron 69:1–7. https://doi.org/10.1016/j.bios.2015.01.011
Lin CC, Yang YM, Chen YF et al (2008) A new protein A assay based on Raman reporter labeled immunogold nanoparticles. Biosens Bioelectron 24:178–183. https://doi.org/10.1016/j.bios.2008.03.035
Lin J, Chen R, Feng S et al (2009) Rapid delivery of silver nanoparticles into living cells by electroporation for surface-enhanced Raman spectroscopy. Biosens Bioelectron 25:388–394. https://doi.org/10.1016/j.bios.2009.07.027
Liu Z, Bai L, Zhao G, Liu Y (2016) Sandwich-like layer-by-layer assembly of gold nanoparticles with tunable SERS properties. Beilstein J Nanotechnol 7:1028–1032. https://doi.org/10.3762/bjnano.7.95
Liu Z, Chen H, Jia Y et al (2018) A two-dimensional fingerprint nanoprobe based on black phosphorus for bio-SERS analysis and chemo-photothermal therapy. Nanoscale 10:18795–18804. https://doi.org/10.1039/c8nr05300f
Long DA (2002) Raman effect: a unified treatment of Raman scattering by molecules. Wiley, New York
Lv Y, Qin Y, Svec F, Tan T (2016) Molecularly imprinted plasmonic nanosensor for selective SERS detection of protein biomarkers. Biosens Bioelectron 80:433–441. https://doi.org/10.1016/j.bios.2016.01.092
Lyandres O, Shah NC, Yonzon CR et al (2005) Real-time glucose sensing by surface-enhanced Raman spectroscopy in bovine plasma facilitated by a mixed decanethiol/mercaptohexanol partition layer. Anal Chem 77:6134–6139. https://doi.org/10.1021/ac051357u
Mao Z, Song W, Chen L et al (2011) Metal-semiconductor contacts induce the charge-transfer mechanism of surface-enhanced Raman scattering. J Phys Chem C 115:18378–18383. https://doi.org/10.1021/jp206455a
Maxwell DJ, Emory SR, Nie S (2001) Nanostructured thin-film materials with surface-enhanced optical properties. Chem Mater 13:1082–1088. https://doi.org/10.1021/cm0009120
McCreery RL (2000) Raman spectroscopy for chemical analysis. Wiley, New York
Mirkin CA, Letsinger RL, Mucic RC, Storhoff JJ (1996) A DNA-based method for rationally assembling nanoparticles into macroscopic materials. Nature 382:607–609
Monaghan PB, McCarney KM, Ricketts A et al (2007) Bead-based DNA diagnostic assay for chlamydia using nanoparticle-mediated surface-enhanced resonance Raman scattering detection within a lab-on-a-chip format. Anal Chem 79:2844–2849. https://doi.org/10.1021/ac061769i
Murphy CJ, Gole AM, Hunyadi SE et al (2008) Chemical sensing and imaging with metallic nanorods. Chem Commun 1:544–557. https://doi.org/10.1039/b711069c
Neng J, Harpster MH, Zhang H et al (2010) A versatile SERS-based immunoassay for immunoglobulin detection using antigen-coated gold nanoparticles and malachite green-conjugated protein A/G. Biosens Bioelectron 26:1009–1015. https://doi.org/10.1016/j.bios.2010.08.015
Ngo HT, Freedman E, Odion RA et al (2018) Direct detection of unamplified pathogen RNA in blood lysate using an integrated lab-in-a- stick device and ultrabright SERS nanorattles. Sci Rep 8:1–13
Nie S, Emory SR (1997) Probing single molecules and single nanoparticles by surface-enhanced Raman scattering. Science 275:1102–1106. https://doi.org/10.1126/science.275.5303.1102
Nikoobakht B, El-Sayed MA (2003) Surface-enhanced Raman scattering studies on aggregated gold nanorods. J Phys Chem A 107:3372–3378. https://doi.org/10.1021/jp026770+
Orendorff CJ, Gole A, Sau TK, Murphy CJ (2005) Surface-enhanced Raman spectroscopy of self-assembled monolayers: sandwich architecture and nanoparticle shape dependence. Anal Chem 77:3261–3266. https://doi.org/10.1021/ac048176x
Orendorff CJ, Gearheart L, Jana NR, Murphy CJ (2006) Aspect ratio dependence on surface enhanced Raman scattering using silver and gold nanorod substrates. Phys Chem Chem Phys 8:165–170. https://doi.org/10.1039/b512573a
Otto A, Mrozek I, Grabhorn H, Akemann W (1992) Surface-enhanced Raman scattering. J Phys Condens Matter 4:1143–1212
Palonpon AF, Sodeoka M, Fujita K (2013) Molecular imaging of live cells by Raman microscopy. Curr Opin Chem Biol 17:708–715. https://doi.org/10.1016/j.cbpa.2013.05.021
Pang Y, Wan N, Shi L et al (2019) Dual-recognition surface-enhanced Raman scattering (SERS) biosensor for pathogenic bacteria detection by using vancomycin-SERS tags and aptamer-Fe3O4@Au. Anal Chim Acta 1077:288–296. https://doi.org/10.1016/j.aca.2019.05.059
Park T, Lee S, Seong GH et al (2005) Highly sensitive signal detection of duplex dye-labelled DNA oligonucleotides in a PDMS microfluidic chip: confocal surface-enhanced Raman spectroscopic study. Lab Chip 5:437–442. https://doi.org/10.1039/b414457k
Pavel I, McCarney E, Elkhaled A et al (2008) Label-free SERS detection of small proteins modified to act as bifunctional linkers. J Phys Chem C 112:4880–4883. https://doi.org/10.1021/jp710261y
Pazos-Perez N, Pazos E, Catala C et al (2016) Ultrasensitive multiplex optical quantification of bacteria in large samples of biofluids. Sci Rep 6:1–10. https://doi.org/10.1038/srep29014
Pearson B, Mills A, Tucker M et al (2018) Rationalizing and advancing the 3-MPBA SERS sandwich assay for rapid detection of bacteria in environmental and food matrices. Food Microbiol 72:89–97. https://doi.org/10.1016/j.fm.2017.11.007
Perumal J, Dinish U, Bendt AK et al (2018) Identification of mycolic acid forms using surface-enhanced Raman scattering as a fast detection method for tuberculosis. Int J Nanomedicine 13:6029–6038. https://doi.org/10.2147/IJN.S171400
Pham X-H, Shim S, Kim T-H et al (2017) Glucose detection using 4-mercaptophenyl boronic acid-incorporated silver nanoparticles-embedded silica-coated graphene oxide as a SERS substrate. Biochip J 11:46–56. https://doi.org/10.1007/s13206-016-1107-6
Procházka M (2016) Surface enhanced Raman spectroscopy bioanalytical, biomolecular and medical applications. Springer International Publishing, Basel
Quagliano LG (2004) Observation of molecules adsorbed on III-V semiconductor quantum dots by surface-enhanced Raman scattering. J Am Chem Soc 126:7393–7398. https://doi.org/10.1021/ja031640f
Raman CV, Kariamanikkam KS (1928) A new type of secondary radiation. Nature 121:501–502
Sanles-Sobrido M, Rodrıguez-Lorenzo L, Lorenzo-Abalde S et al (2009) Label-free SERS detection of relevant bioanalytes on silver-coated carbon nanotubes: the case of cocaine. Nanoscale 1:153–158. https://doi.org/10.1039/b9nr00059c
Sarau G, Lahiri B, Banzer P et al (2013) Enhanced Raman scattering of Graphene using arrays of split ring resonators. Adv Opt Mater 1:151–157. https://doi.org/10.1002/adom.201200053
Schultz DA (2003) Plasmon resonant particles for biological detection. Curr Opin Biotechnol 14:13–22. https://doi.org/10.1016/S0958-1669(02)00015-0
Schwarzmeier K, Knauer M, Ivleva NP et al (2013) Bioaerosol analysis based on a label-free microarray readout method using surface-enhanced Raman scattering. Anal Bioanal Chem 405:5387–5392. https://doi.org/10.1007/s00216-013-6984-0
Seefeld TH, Zhou W-J, Corn RM (2011) Rapid microarray detection of DNA and proteins in microliter volumes with SPR imaging measurements. Langmuir 27:6534–6540. https://doi.org/10.1021/la200649n
Sikirzhytski V, Virkler K, Lednev IK (2010) Discriminant analysis of Raman spectra for body fluid identification for forensic purposes. Sensors 10:2869–2884. https://doi.org/10.3390/s100402869
Sivanesan A, Witkowska E, Adamkiewicz W et al (2014) Nanostructured silver–gold bimetallic SERS substrates for selective identification of bacteria in human blood. Analyst 139:1037–1043. https://doi.org/10.1039/c3an01924a
Smith E, Dent G (2005) Modern Raman spectroscopy: a practical approach. J Raman Spectrosc 36:835. https://doi.org/10.1002/jrs.13200956
Smith R, Wrightb KL, Ashton L (2016) Raman spectroscopy: an evolving technique for live cell studies. Analyst 141:3590–3600. https://doi.org/10.1039/c6an00152a
Song C, Wei Y, Da B et al (2016) In situ growth of monolayer porous gold nanoparticles film as high-performance SERS substrates. Mater Res Exp 3:1–9. https://doi.org/10.1088/2053-1591/3/7/075013
Stevenson CL, Vo-Dinh T (1996) Modern tecchniques in Raman spectroscopy. Wiley, West Sussex
Stiles PL, Dieringer JA, Shah NC, Duyne RPV (2008) Surface-enhanced Raman spectroscopy. Annu Rev Anal Chem 1:601–626
Stosch R, Yaghobian F, Weimann T et al (2011) Lithographical gap-size engineered nanoarrays for surface-enhanced Raman probing of biomarkers. Nanotechnology 22:1–6. https://doi.org/10.1088/0957-4484/22/10/105303
Strelau KK, Kretschmer R, Möller R et al (2010) SERS as tool for the analysis of DNA-chips in a microfluidic platform. Anal Bioanal Chem 396:1381–1384. https://doi.org/10.1007/s00216-009-3374-8
Strobel HA, Heineman WR (1989) Chemical instrumentation: a systematic approach. Wiley, New York
Su J, Wang D, Nörbel L et al (2017) Multicolor gold−silver nano-mushrooms as ready-to-use SERS probes for ultrasensitive and multiplex DNA/miRNA detection. Anal Chem 89:2531–2538. https://doi.org/10.1021/acs.analchem.6b04729
Su SR, Chen YY, Li KY et al (2019) Electrohydrodynamically enhanced drying droplets for concentration of Salmonella bacteria prior to their detections using antibody-functionalized SERS-reporter submicron beads. Sens Actuators B Chem 283:384–389
Tamer U, Cetin D, Suludere Z et al (2013) Gold-coated iron composite nanospheres targeted the detection of Escherichia coli. Int J Mol Sci 14:6223–6240. https://doi.org/10.3390/ijms14036223
Temur E, BoyacI IH, Tamer U et al (2010) A highly sensitive detection platform based on surface-enhanced Raman scattering for Escherichia coli enumeration. Anal Bioanal Chem 397:1595–1604. https://doi.org/10.1007/s00216-010-3676-x
Tessier PM, Velev OD, Kalambur AT et al (2000) Assembly of gold nanostructured films templated by colloidal crystals and use in surface-enhanced Raman spectroscopy. J Am Chem Soc 122:9554–9555. https://doi.org/10.1021/ja0022831
Toccafondi C, La Rocca R, Scarpellini A et al (2015) Thin nanoporous alumina-based SERS platform for single cell sensing. Appl Surf Sci 351:738–745
Torul H, Çiftçi H, Dudak FC et al (2014) Glucose determination based on a two component self-assembled monolayer functionalized surface- enhanced Raman spectroscopy (SERS) probe. Anal Methods 6:5097–5104. https://doi.org/10.1039/c4ay00559g
Torul H, Ciftci H, Cetin D et al (2015) Paper membrane-based SERS platform for the determination of glucose in blood samples. Anal Bioanal Chem 407:8243–8251. https://doi.org/10.1007/s00216-015-8966-x
Tuyen LD, Liu AC, Huang C-C et al (2012) Doubly resonant surface-enhanced Raman scattering on gold nanorod decorated inverse opal photonic crystals. Opt Express 20:29266–29275. https://doi.org/10.1364/OE.20.029266
Wang Y, Schlücker S (2013) Rational design and synthesis of SERS labels. Analyst 138:2224–2238. https://doi.org/10.1039/c3an36866a
Wang Y, Ravindranath S, Irudayaraj J (2011a) Separation and detection of multiple pathogens in a food matrix by magnetic SERS nanoprobes. Anal Bioanal Chem 399:1271–1278. https://doi.org/10.1007/s00216-010-4453-6
Wang Z, Zong S, Chen H et al (2011b) Silica coated gold nanoaggregates prepared by reverse microemulsion method: dual mode probes for multiplex immunoassay using SERS and fluorescence. Talanta 86:170–177. https://doi.org/10.1016/j.talanta.2011.08.054
Wang J, Duan G, Liu G et al (2015a) Fabrication of gold and silver hierarchically micro/nanostructured arrays by localized electrocrystallization for application as SERS substrates. J Mater Chem C 3:5709–5714. https://doi.org/10.1039/c5tc00790a
Wang P, Xia M, Liang O et al (2015b) Label-free SERS selective detection of dopamine and serotonin using graphene-Au nanopyramid heterostructure. Anal Chem 87:10255–10261. https://doi.org/10.1021/acs.analchem.5b01560
Wang C, Wang J, Li M et al (2016a) A rapid SERS method for label-free bacteria detection using polyethylenimine-modified Au-coated magnetic microspheres and Au@Ag nanoparticles. Analyst 141:6226–6238. https://doi.org/10.1039/c6an01105e
Wang P, Pang S, Chen J et al (2016b) Label-free mapping of single bacterial cells using surface-enhanced Raman spectroscopy. Analyst 141:1356–1362. https://doi.org/10.1039/c5an02175h
Wen C, Liao F, Liu S et al (2013) Bi-functional ZnO–RGO–Au substrate: photocatalysts for degrading pollutants and SERS substrates for real-time monitoring. Chem Commun 49:3049–3051. https://doi.org/10.1039/c3cc37877b
Wilson SM, Bacic A (2012) Preparation of plant cells for transmission electron microscopy to optimize immunogold labeling of carbohydrate and protein epitopes. Nat Protoc 7:1716–1727. https://doi.org/10.1038/nprot.2012.096
Woo M-A, Lee S-M, Kim G et al (2009) Multiplex immunoassay using fluorescent-surface enhanced Raman spectroscopic dots for the detection of bronchioalveolar stem cells in murine lung. Anal Biochem 81:1008–1015. https://doi.org/10.1021/ac802037x
Wu X, Xu C, Tripp RA et al (2013) Detection and differentiation of foodborne pathogenic bacteria in mung bean sprouts using field deployable label-free SERS devices. Analyst 138:3005–3012
Wu X, Huang Y-W, Park B et al (2015) Differentiation and classification of bacteria using vancomycin functionalized silver nanorods array based surface-enhanced Raman spectroscopy and chemometric analysis. Talanta 139:96–103. https://doi.org/10.1016/j.talanta.2015.02.045
Xu W, Xu S, Ji X et al (2005) Preparation of gold colloid monolayer by immunological identification. Colloids Surf B Biointerfaces 40:169–172. https://doi.org/10.1016/j.colsurfb.2004.10.027
Xu W, Ling X, Xiao J et al (2012) Surface enhanced Raman spectroscopy on a flat graphene surface. Proc Natl Acad Sci U S A 109:9281–9286. https://doi.org/10.1073/pnas.1205478109
Yan Z, Du W, Tu L et al (2015) A facile high-performance SERS substrate based on broadband near-perfect optical absorption. J Raman Spectrosc 46:795–801
Yang D, Zhou H, Haisch C et al (2016) Reproducible E. coli detection based on label-free SERS and mapping. Talanta 146:457–463. https://doi.org/10.1016/j.talanta.2015.09.006
Yazgan NN, Boyaci IH, Temur E et al (2010) A high sensitive assay platform based on surface-enhanced Raman scattering for quantification of protease activity. Talanta 82:631–639
Yazgan NN, Boyacı İH, Topcu A, Tamer U (2012) Detection of melamine in milk by surface-enhanced Raman spectroscopy coupled with magnetic and Raman-labeled nanoparticles. Anal Bioanal Chem 403:2009–2017. https://doi.org/10.1007/s00216-012-5971-1
Yilmaz M, Senlik E, Biskin E et al (2014) Combining 3-D plasmonic gold nanorod arrays with colloidal nanoparticles as a versatile concept for reliable, sensitive, and selective molecular detection by SERS. PhysChemChemPhys 16:5563–5570. https://doi.org/10.1039/c3cp55087g
Yilmaz M, Ozdemir M, Erdogan H et al (2015) Micro-/nanostructured highly crystalline organic semiconductor films for surface-enhanced Raman spectroscopy applications. Adv Funct Mater 25:5669–5676
Yu Q, Guan P, Qin D et al (2008) Inverted size-dependence of surface-enhanced Raman scattering on gold nanohole and nanodisk arrays. Nano Lett 8:1923–1928. https://doi.org/10.1021/nl0806163
Yue W, Yang Y, Wang Z et al (2012) Surface-enhanced Raman scattering on gold nanorod pairs with interconnection bars of different widths. Sens Actuators B Chem 171–172:734–738. https://doi.org/10.1016/j.snb.2012.05.064
Yue W, Yang Y, Wang Z et al (2013) Gold split-ring resonators (SRRs) as substrates for surface-enhanced Raman scattering. J Phys Chem C 117:21908–21915. https://doi.org/10.1021/jp404332n
Yüksel S, Schwenkbier L, Pollok S et al (2015) Label-free detection of Phytophthora ramorum using surface-enhanced Raman spectroscopy. Analyst 140:7254–7262. https://doi.org/10.1039/c5an01156f
Zhang X, Whitney AV, Zhao J et al (2006) Advances in contemporary nanosphere lithographic techniques. J Nanosci Nanotechnol 6:1920–1934
Zhang H, Liu M, Zhou F et al (2015a) Physical deposition improved SERS stability of morphology controlled periodic micro/nanostructured arrays based on colloidal templates. Small 11:844–853
Zhang L, Li X, Ong L et al (2015b) Cellulose nanofibre textured SERS substrate. Colloids Surf A Physicochem Eng Asp 468:309–314. https://doi.org/10.1016/j.colsurfa.2014.12.056
Zhang L, Guan C, Wang Y, Liao J (2016) Highly effective and uniform SERS substrates fabricated by etching multi-layered gold nanoparticle arrays. Nanoscale 8:5928–5937. https://doi.org/10.1039/c6nr00502k
Zheng T, Gao Z, Luo Y et al (2016) Manual-slide-engaged paper chip for parallel SERS-immunoassay measurement of clenbuterol from swine hair. Electrophoresis 37:418–424. https://doi.org/10.1002/elps.201500324
Zhou H, Yang D, Ivleva NP et al (2014) SERS detection of bacteria in water by in situ coating with Ag nanoparticles. Anal Chem 86:1525–1533. https://doi.org/10.1021/ac402935p
Zhu J, Du H, Zhang Q et al (2019) SERS detection of glucose using graphene-oxide- wrapped gold nanobones with silver coating. J Mater Chem C 7:3322–3334. https://doi.org/10.1039/c8tc05942j
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2021 The Author(s), under exclusive license to Springer Nature Switzerland AG
About this chapter
Cite this chapter
Tamer, U. et al. (2021). SERS Sensor Applications in Environmental Analysis and Biotechnology. In: Saglam, N., Korkusuz, F., Prasad, R. (eds) Nanotechnology Applications in Health and Environmental Sciences. Nanotechnology in the Life Sciences. Springer, Cham. https://doi.org/10.1007/978-3-030-64410-9_11
Download citation
DOI: https://doi.org/10.1007/978-3-030-64410-9_11
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-030-64409-3
Online ISBN: 978-3-030-64410-9
eBook Packages: Biomedical and Life SciencesBiomedical and Life Sciences (R0)