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Stem Cell Therapy for Stroke

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Stem Cell Therapy for Vascular Diseases

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Abstract

Stroke is one of the leading causes of disability and death around the world. As effectiveness of treatments for this pathology continues to advance, the number of people living with the sequelae is increasing as well. The current treatments, intravenous tissue plasminogen activator (tPA) and mechanical thrombectomy have improved the survival of patients in the acute setting by restoring blood flow through the brain vasculature. However, due to various complicating factors (timing of presentation, capabilities of medical centers, comorbidities of patient), not all patients receive these therapies, and for those that do, many have incurred brain damage prior to revascularization. Preclinical research over the past few decades has shown that in animal models of stroke, stem cell therapy can improve recovery and functional outcome in the post-ischemic brain. Although proven successful in preclinical trials, the clinical application of stem cells in stroke remains an area of active research to determine the effectiveness and safety profile in humans. However, studies are encouraging, and although there are many questions that remain to be answered, stem cell therapy for stroke appears to be a promising treatment for patients suffering from this devastating neurological disorder.

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  1. Department of Neurosurgery, Yale University School of Medicine, New Haven, CT, USA

    S. M. Robert & C. Matouk

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Correspondence to C. Matouk .

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Editors and Affiliations

  1. Department of Surgery, Vascular Surgery Section, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil

    Tulio Pinho Navarro

  2. Postgraduate Program in Sciences Applied to Surgery, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil

    Lara Lellis Navarro Minchillo Lopes

  3. Vascular Biology and Therapeutics Program and the Departments of Surgery and Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, CT, USA

    Alan Dardik

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Robert, S.M., Matouk, C. (2021). Stem Cell Therapy for Stroke. In: Navarro, T.P., Minchillo Lopes, L.L.N., Dardik, A. (eds) Stem Cell Therapy for Vascular Diseases. Springer, Cham. https://doi.org/10.1007/978-3-030-56954-9_15

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