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Plant Polysaccharides in Pharmaceutical Applications

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Bioactive Natural Products for Pharmaceutical Applications

Part of the book series: Advanced Structured Materials ((STRUCTMAT,volume 140))

Abstract

Plant polysaccharides are the by-products of photosynthesis within the plants and are being extracted from different parts of the plants, such as leaves, pods, fruits, seeds, cereals, stems, roots, rhizomes, corms, exudates, etc. The important advantages for the uses of plant polysaccharides include easy availability from the nature as plant resources are abundant, sustainable and low cost production, biodegradability, biocompatibility, water solubility, swelling ability, etc. Since long, numerous plant polysaccharides have already been explored and exploited as excipients in a variety of common pharmaceutical dosage forms, such as suspensions, emulsions, gels, tablets, capsules, beads, microparticles, nanoparticles, liposomes, transdermal formulations, buccal formulations, nasal formulations, ophthalmic formulations, etc. The current chapter presents a brief review on the pharmaceutical applications of various plant polysaccharides.

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References

  • Adhikari SNR, Panda S (2017) Buccal patches of atenolol formulated using fenugreek (Trigonella foenum-graecum L.) seed mucilage. Polim Med 47:5–11

    Article  Google Scholar 

  • Ahuja M, Kumar A, Yadav P, Singh K (2013) Mimosa pudica seed mucilage: Isolation, characterization and evaluation as tablet disintegrant and binder. Int J Biol Macromol 57:105–110

    Article  CAS  Google Scholar 

  • Ahuja M, Kumar S, Kumar A (2013) Evaluation of mucoadhesive potential of gum cordia, an anionic polysaccharide. Int J Biol Macromol 55:109–112

    Article  CAS  Google Scholar 

  • Ali SA, Nayak AK, Sen KK, Prabhakar T (2019) Preparation and characterization of vetiver oil encapsulated polymeric microcapsules for sedative and hypnotic activity. Int J Res Pharm Sci 10:3616–3625

    Article  CAS  Google Scholar 

  • Avachat A, Gujar KN, Wagh KV (2013) Development and evaluation of tamarind seed glucan-based mucoadhesive buccal films of rizatriptan benzoate. Carbohydr Polym 91:537–542

    Article  CAS  Google Scholar 

  • Avachat AM, Dash RR, Shrotriya SN (2011) Recent investigations of plant based natural gums, mucilages and resins in novel drug delivery systems. Indian J Pharm Educ Res 45:86–99

    Google Scholar 

  • Avlani D, Agarwal V, Khattry V, Biswas GR, Majee SB (2019) Exploring properties of sweet basil seed mucilage in development of pharmaceutical suspensions and surfactant-free stable emulsions. Int J Appl Pharm 11:124–129

    Article  CAS  Google Scholar 

  • Basu S, Chakraborty S, Bandyopadhyay AK (2007) Development and evaluation of a mucoadhesive nasal gel of midazolam prepared with Linum usitatissimum L. seed mucilage. Sci Pharm 77:899–910

    Google Scholar 

  • Bera H, Abbasi YF, Hasnain MS, Nayak AK (2019) Sterculia gum in drug delivery applications. In: Hasnain MS, Nayak AK, (eds.,), Natural polysaccharides in drug delivery and biomedical applications. Academic Press, Elsevier Inc., pp 223–247

    Google Scholar 

  • Bera H, Boddupalli S, Nandikonda S, Kumar S, Nayak AK (2015) Alginate gel-coated oil-entrapped alginate–tamarind gum–magnesium stearate buoyant beads of risperidone. Int J Biol Macromol 78:102–111

    Article  CAS  Google Scholar 

  • Bera H, Boddupalli S, Nayak AK (2015) Mucoadhesive-floating zinc-pectinate-sterculia gum interpenetrating polymer network beads encapsulating ziprasidone HCl. Carbohydr Polym 131:108–118

    Article  CAS  Google Scholar 

  • Bera H, Kandukuri SG, Nayak AK, Boddupalli S (2015) Alginate-sterculia gum gel-coated oil-entrapped alginate beads for gastroretentive risperidone delivery. Carbohydr Polym 120:74–84

    Article  CAS  Google Scholar 

  • Builders PF, Anwunobi AP, Mbah CC, Adikwu MU (2013) New direct compression excipient from tiger nut starch: physicochemical and functional properties. AAPS PharmSciTech 14:818–827

    Article  CAS  Google Scholar 

  • Builders PF, Arhewoh MI (2016) Pharmaceutical applications of native starch in conventional drug delivery. Starch/Stärke 68:1–10

    Article  CAS  Google Scholar 

  • Burapapadh K, Takeuchi H, Sriamornsak P (2012) Novel pectin-based nanoparticles prepared from nanoemulsion templates for improving in vitro dissolution and in vivo absorption of poorly water-soluble drug. Eur J Pharm Biopharm 82:250–261

    Article  CAS  Google Scholar 

  • Das B, Dutta S, Nayak AK, Nanda U (2014) Zinc alginate-carboxymethyl cashew gum microbeads for prolonged drug release: Development and optimization. Int J Biol Macromol 70:505–515

    Article  CAS  Google Scholar 

  • Das B, Nayak AK, Nanda U (2013) Topical gels of lidocaine HCl using cashew gum and Carbopol 940: Preparation and in vitro skin permeation. Int J Biol Macromol 62:514–517

    Article  CAS  Google Scholar 

  • Datta R, Bandyopadhyay AK (2006) A new nasal drug delivery system for diazepam using natural mucoadhesive polysaccharide obtained from tamarind seeds. Saudi Pharm J 14:115–119

    CAS  Google Scholar 

  • Dey S, Nandy BC, De JN, Hasnain MS, Nayak AK (2019) Tamarind gum in drug delivery applications. In: Hasnain MS, Nayak AK, (eds.,), Natural polysaccharides in drug delivery and biomedical applications. Academic Press, Elsevier Inc., pp 285–306

    Google Scholar 

  • Dhupal M, Gupta MK, Tripathy DR, Kumar M, Yi DK, Nanda SS, Chowdhury D (2019) Recent advances in pharmaceutical applications of natural carbohydrate polymer gum tragacanth, In: Nayak AK, Hasnain MS, Pal D, (eds.,), Natural Polymers for pharmaceutical applications, volume I: plant derived polymers. Apple Academic Press, USA, pp 49–85

    Google Scholar 

  • Dilbaghi N, Kaur H, Ahuja M, Kumar S (2013) Evaluation of tropicamide-loaded tamarind seed xyloglucan nanoaggregates for ophthalmic delivery. Carbohydr Polym 94:286–291

    Article  CAS  Google Scholar 

  • Dodi G, Pala A, Barbu E, Peptanariu D, Hritcu D, Popa MI, Tamba BI (2016) Carboxymethyl guar gum nanoparticles for drug delivery applications: Preparation and preliminary in-vitro investigations. Mater Sci Eng C 63:628–636

    Article  CAS  Google Scholar 

  • El-Gibaly I (2002) Oral delayed-release system based on Zn pectinate gel (ZPG) microparticles as an alternative carrier to calcium pectinate beads for colonic drug delivery. Int J Pharm 232:199–211

    Article  CAS  Google Scholar 

  • Gaikar N, Sandhya P (2012) Evaluation of Aegle marmelos fruit mucilage for binding properties. Int J Pharm Sci Res 3:620–622

    CAS  Google Scholar 

  • Gemede HF, Haki GD, Beyene F, Rakshit SK, Woldegiorgis AZ (2018) Indigenous Ethiopian okra (Abelmoschus esculentus) mucilage: a novel ingredient with functional and antioxidant properties. Food Sci Nutr 6:563–571

    Article  CAS  Google Scholar 

  • George B, Suchithra TV (2019) Plant-derived bioadhesives for wound dressing and drug delivery system. Fitoterapia 137:104241

    Article  CAS  Google Scholar 

  • Gheraldi E, Tavanti A, Celandroni F, Lupetti A, Blandizzi C, Boldrini E, Campa M, Senesi S (2000) Effect of novel mucoadhesive polysaccharide obtained from tamarind seeds on the intraocular penetration of gentamicin and ofloxacin in rabbits. J Antimicrob Chemother 46:831–834

    Article  Google Scholar 

  • Gheraldi E, Tavanti A, Davini P, Celandroni F, Salvetti S, Parisio E et al (2004) A mucoadhesive polymer extracted from tamarind seed improves the intraocular penetration and efficacy of rufloxacin in topical treatment of experimental bacterial keratitis. Antimicrob Agents Chemother 48:3396–3401

    Article  CAS  Google Scholar 

  • Gowthamarajan K, Jawahar N, Wake P, Jain K, Sood S (2012) Development of buccal tablets for curcumin using Anacardium occidentale gum. Carbohydr Polym 88:1177–1183

    Article  CAS  Google Scholar 

  • Guru PR, Bera H, Das M, Hasnain MS, Nayak AK (2018) Aceclofenac-loaded Plantago ovata F. husk mucilage-Zn+2-pectinate controlled-release matrices. Starch/Stärke 70:1700136

    Article  CAS  Google Scholar 

  • Guru PR, Nayak AK, Sahu RK (2013) Oil-entrapped sterculia gum-alginate buoyant systems of aceclofenac: Development and in vitro evaluation. Colloids Surf B: Biointerf 104:268–275

    Article  CAS  Google Scholar 

  • Hadebe S, Ngubane P, Serumula M, Musabayane C (2014) Transdermal delivery of insulin by amidated pectin hydrogel matrix patch in streptozotocin-induced diabetic rats: effects on some selected metabolic parameters. PLoS ONE 9(7).

    Google Scholar 

  • Haghighi M, Yarmand MS, Emam-Djomeh Z, McClements DJ, Saboury AA, Rafiee-Tehrani M (2018) Design and fabrication of pectin-coated nanoliposomal delivery systems for a bioactive polyphenolic: Phloridzin. Int J Biol Macromol 112:626–637

    Article  CAS  Google Scholar 

  • Hasnain MS, Guru PR, Rishishwar P, Ali S, Ansari MT, Nayak AK (2020) Atenolol-releasing buccal patches made of Dillenia indica L. fruit gum: preparation and ex vivo evaluations. SN Appl Sci 2:57

    Article  CAS  Google Scholar 

  • Hasnain MS, Javed MN, Alam MS, Rishishwar P, Rishishwar S, Ali S, Nayak AK, Beg S (2019) Purple heart plant leaves extract-mediated silver nanoparticle synthesis: optimization by Box-Behnken design. Mater Sci Eng C 99:1105–1114

    Article  CAS  Google Scholar 

  • Hasnain MS, Nayak AK, Ansari MT, Pal D (2019b) Pharmaceutical applications of locust bean gum. In: Nayak AK, Hasnain MS, Pal D (eds.,), Natural polymers for pharmaceutical applications, volume I: plant derived polymers. Apple Academic Press, USA, 2019: pp139–162

    Google Scholar 

  • Hasnain MS, Rishishwar P, Ali S (2017a) Floating-bioadhesive matrix tablets of hydralazine HCl made of cashew gum and HPMC K4M. Int J Phar Pharm Sci 9:124–129

    Article  CAS  Google Scholar 

  • Hasnain MS, Rishishwar P, Ali S (2017b) Use of cashew bark exudate gum in the preparation of 4% lidocaine HCl topical gels. Int J Phar Pharm Sci 9:146–150

    Article  CAS  Google Scholar 

  • Hasnain MS, Rishishwar P, Ali S, Alkahtani S, Tabish M, Milivojevic M, Ansari MT, Nayak AK (2020) Formulation and ex vivo skin permeation of lidocaine HCl topical gels using dillenia (Dillenia indica L.) fruit gum. Rev Mex Ing Quím 19:1465–1476

    Article  CAS  Google Scholar 

  • Hasnain MS, Rishishwar P, Ali S, Nayak AK (2020) Preparation and evaluation of aceclofenac dental pastes using dillenia fruit gum for periodontitis treatment. SN Appl Sci 2:1–8

    Article  Google Scholar 

  • Hasnain MS, Rishishwar P, Rishishwar S, Ali S, Nayak AK (2018a) Isolation and characterization of Linum usitatisimum polysaccharide to prepare mucoadhesive beads of diclofenac sodium. Int J Biol Macromol 116:162–172

    Article  CAS  Google Scholar 

  • Hasnain MS, Rishishwar P, Rishishwar S, Ali S, Nayak AK (2018b) Extraction and characterization of cashew tree (Anacardium occidentale) gum; use in aceclofenac dental pastes. Int J Biol Macromol 116:1074–1081

    Article  CAS  Google Scholar 

  • Jana S, Maiti S, Jana S, Sen KK, Nayak AK (2019) Guar gum in drug delivery applications. In: Hasnain MS, Nayak AK, (eds.,), Natural polysaccharides in drug delivery and biomedical applications. Academic Press, Elsevier Inc., pp 187–201

    Google Scholar 

  • Jana S, Saha A, Nayak AK, Sen KK, Basu SK (2013) Aceclofenac-loaded chitosan-tamarind seed polysaccharide interpenetrating polymeric network microparticles. Colloids Surf B: Biointerf 105:303–309

    Article  CAS  Google Scholar 

  • Jena AK, Das M, De A, Mitra D, Samanta A (2014) Determination of efficacy of a natural tablet binder: Characterization and in- vitro release study. Asian J Pharm Clin Res 7:164–168

    CAS  Google Scholar 

  • Jena AK, Nayak AK, De A, Mitra D, Samanta A (2018) Development of lamivudine containing multiple emulsions stabilized by gum odina. Future J Pharm Sci 4:71–79

    Article  Google Scholar 

  • Jha AK, Bhattacharya A (2008) Preparation and in vitro evaluation of sweet potato starch blended sodium alginate microbeads. Adv Nat Appl Sci 2:122–128

    CAS  Google Scholar 

  • Kaleemullah M, Jiyauddin K, Thiban E, Rasha S, Al-Dhalli S, Budiasih S, Gamal OE, Fadli A, Eddy Y (2017) Development and evaluation of ketoprofen sustained release matrix tablet using Hibiscus rosa-sinensis leaves mucilage. Saudi Pharm J 25:770–779

    Article  CAS  Google Scholar 

  • Ketousetuo K, Bandyopadhyay AK (2007) Development of oxytocin nasal gel using natural mucoadhesive agent obtained from the fruits of Dellinia indica L. Sci Asia 33:57–60

    Article  CAS  Google Scholar 

  • Khunkitti W, Aromdee C, Vorarat S, Chitropas P (2006) The potential of jackfruit starch for use as suspending agent and emulsifying agent. Songklanakarin J Sci Technol 28:145–155

    Google Scholar 

  • Lago AMT, Neves ICO, Oliveira NL, Botrel DA, Minim LA, de Resende JV (2019) Ultrasound-assisted oil-in-water nanoemulsion produced from Pereskia aculeata Miller mucilage. Ultrason Sonochem 50:339–353

    Article  CAS  Google Scholar 

  • Malakar J, Nayak AK, Das A (2013) Modified starch (cationized)-alginate beads containing aceclofenac: Formulation optimization using central composite design. Starch/Stärke 65:603–612

    Article  CAS  Google Scholar 

  • Malakar J, Nayak AK, Jana P, Pal D (2013) Potato starch-blended alginate beads for prolonged release of tolbutamide: Development by statistical optimization and in vitro characterization. Asian J Pharm 7:43–51

    Article  Google Scholar 

  • Malviya R, Srivastava P, Kulkarni GT (2011) Applications of mucilages in drug delivery-a review. Adv Biol Res 5:1–7

    Google Scholar 

  • Manek RV, Builders PF, Kolling WM, Emeje M, Kunle OO (2012) Physicochemical and binder properties of starch obtained from Cyperus esculentus. AAPS PharmSciTech 13:379–388

    Article  CAS  Google Scholar 

  • Mehra GR, Manish M, Rashi S, Neeraj G, Mishra DN (2010) Enhancement of miotic potential of pilocarpine by tamarind gum based in situ gelling ocular dosage form. Acta Pharm Sci 52:145–154

    CAS  Google Scholar 

  • Menon SS, Basavraj BV, Bharath S, Deveswaran R, Madhavan V (2011) Formulation and evaluation of ibuprofen tablets using orange peel pectin as binding agent. Der Pharm Lett 3:241–247

    CAS  Google Scholar 

  • Misale BV, Gavali HBM, Katare SD, Yadav AV (2008) Sago starch capsule shell: A suitable alternative to gelatin capsule shells. Indian J Pharm Educ Res 42:48–52

    Google Scholar 

  • Mishra MU, Khandare JN (2011) Evaluation of tamarind seed polysaccharide as a biodegradable carrier for colon specific drug delivery. Int J Pharm Pharmaceut Sci 3:139–142

    CAS  Google Scholar 

  • Mohanty S, Mohan GK, Reddy MS (2015) Formulation, evaluation and optimization of sustained release microcapsules of lornoxicam prepared with gum dikamali & pectin extracted from Dillenia indica. Int J Chem Sci 13:97–106

    CAS  Google Scholar 

  • Mundhe MR, Pagore RR, Biyani KR (2012) Isolation and evaluation of Trigonella foenum-gracum mucilage as gelling agent in diclofenac potassium gel. Int J Ayur Herb Med 2:300–306

    Google Scholar 

  • Mylangam CK, Beeravelli S, Medikonda J, Pidaparthi JS, Kolapalli VR (2016) Badam gum: a natural polymer in mucoadhesive drug delivery. Design, optimization, and biopharmaceutical evaluation of badam gum-based metoprolol succinate buccoadhesive tablets. Drug Deliv 23:195–206

    Article  CAS  Google Scholar 

  • Narkhede SB, Bendale AR, Jadhav AG, Patel K, Vidyasagar G (2011) Isolation and evaluation of starch of Artocarpus heterophyllus as a tablet binder. Int J PharmTech Res 3:836–840

    CAS  Google Scholar 

  • Nayak AK (2016) Tamarind seed polysaccharide-based multiple-unit systems for sustained drug release. In: Kalia S, Averous L (eds) Biodegradable and bio-based polymers: environmental and biomedical applications. WILEY-Scrivener, USA, pp 471–494

    Google Scholar 

  • Nayak AK, Ansari MT, Sami F, Bera H, Hasnain MS (2019) Cashew gum in drug delivery applications. In: Hasnain MS, Nayak AK, (eds) Natural polysaccharides in drug delivery and biomedical applications. Academic Press, Elsevier Inc., pp 263–283

    Google Scholar 

  • Nayak AK, Ara TJ, Hasnain MS, Hoda N (2018b) Okra gum-alginate composites for controlled releasing drug delivery, In: Inamuddin, Asiri AM, Mohammad A (eds) Applications of nanocomposite materials in drug delivery. Elsevier Inc., pp 761–785

    Google Scholar 

  • Nayak AK, Beg S, Hasnain MS, Malakar J, Pal D (2018) Soluble starch-blended Ca2+-Zn2+-alginate composites-based microparticles of aceclofenac: Formulation development and in vitro characterization. Future J Pharm Sci 4:63–70

    Article  Google Scholar 

  • Nayak AK, Bera H, Hasnain MS, Pal D (2018a) Synthesis and characterization of graft-copolymers of plant polysaccharides, In: Thakur VK (ed) Biopolymer grafting, synthesis and properties. Elsevier Inc., pp 1–62

    Google Scholar 

  • Nayak AK, Hasnain MS (2019a) Plant polysaccharides in drug delivery applications. In: Nayak AK, Hasnain MS (eds) Plant polysaccharides-based multiple-unit systems for oral drug delivery. Springer, Singapore, pp 19–23

    Chapter  Google Scholar 

  • Nayak AK, Hasnain MS (2019b) Some other plant polysaccharide based multiple units for oral drug delivery. In: Nayak AK, Hasnain MS (eds) Plant polysaccharides-based multiple-unit systems for oral drug delivery. Springer, Singapore, pp 123–1128

    Chapter  Google Scholar 

  • Nayak AK, Hasnain MS (2019c) Gum Arabic based multiple units for oral drug delivery. In: Nayak AK, Hasnain MS (eds) Plant polysaccharides-based multiple-unit systems for oral drug delivery. Springer, Singapore, pp 25–30

    Chapter  Google Scholar 

  • Nayak AK, Hasnain MS (2019d) Locust bean gum based multiple units for oral drug delivery. In: Nayak AK, Hasnain MS (eds) Plant polysaccharides-based multiple-unit systems for oral drug delivery. Springer, Singapore, pp 61–66

    Chapter  Google Scholar 

  • Nayak AK, Hasnain MS (2019e) Sterculia gum based multiple units for oral drug delivery. In: Nayak AK, Hasnain MS (eds) Plant polysaccharides-based multiple-unit systems for oral drug delivery. Springer, Singapore, pp 67–82

    Chapter  Google Scholar 

  • Nayak AK, Hasnain MS (2019f) Tamarind polysaccharide based multiple units for oral drug delivery. In: Nayak AK, Hasnain MS (eds) Plant Polysaccharides-Based Multiple-Unit Systems for Oral Drug Delivery. Springer, Singapore, pp 31–59

    Chapter  Google Scholar 

  • Nayak AK, Hasnain MS (2019g) Okra gum based multiple units for oral drug delivery. In: Nayak AK, Hasnain MS (eds) Plant polysaccharides-based multiple-unit systems for oral drug delivery. Springer, Singapore, pp 83–92

    Chapter  Google Scholar 

  • Nayak AK, Hasnain MS (2019h) Fenugreek seed mucilage based multiple units for oral drug delivery. In: Nayak AK, Hasnain MS (eds) Plant polysaccharides-based multiple-unit systems for oral drug delivery. Springer, Singapore, pp 93–112

    Chapter  Google Scholar 

  • Nayak AK, Hasnain MS (2019i) Linseed polysaccharide based multiple units for oral drug delivery. In: Nayak AK, Hasnain MS (eds) Plant polysaccharides-based multiple-unit systems for oral drug delivery. Springer, Singapore, pp 117–121

    Chapter  Google Scholar 

  • Nayak AK, Hasnain MS (2019j) Potato starch based multiple units for oral drug delivery. In: Nayak AK, Hasnain MS (eds) Plant polysaccharides-based multiple-unit systems for oral drug delivery. Springer, Singapore, pp 113–116

    Chapter  Google Scholar 

  • Nayak AK, Hasnain MS (2019k) Background: Multiple units in oral drug delivery. In: Nayak AK, Hasnain MS (eds) Plant polysaccharides-based multiple-unit systems for oral drug delivery. Springer, Singapore, pp 1–17

    Chapter  Google Scholar 

  • Nayak AK, Hasnain MS, Pal D (2018c) Gelled microparticles/beads of sterculia gum and tamarind gum for sustained drug release, In: V.K. Thakur, M.K. Thakur (eds) Handbook of Springer on polymeric gel. Springer International Publishing, Switzerland, pp 361–414

    Google Scholar 

  • Nayak AK, Hasnain MS, Pal K, Banerjee I, Pal D (2020) Gum-based hydrogels in drug delivery. Pal K, Banerjee I, Sarkar P, Kim D, Deng W-P, Dubey NK, Majumder K, (eds) Biopolymer-based formulations. Elsevier Inc., pp 605–645

    Google Scholar 

  • Nayak AK, Pal D (2012) Natural polysaccharides for drug delivery in tissue engineering. Everyman’s Science XLVI: 347–352.

    Google Scholar 

  • Nayak AK, Pal D (2013a) Ionotropically-gelled mucoadhesive beads for oral metformin HCl delivery: Formulation, optimization and antidiabetic evaluation. J Sci Ind Res 72:15–22

    CAS  Google Scholar 

  • Nayak AK, Pal D (2013b) Blends of jackfruit seed starch-pectin in the development of mucoadhesive beads containing metformin HCl. Int J Biol Macromol 62:137–145

    Article  CAS  Google Scholar 

  • Nayak AK, Pal D (2013c) Formulation optimization of jackfruit seed starch-alginate mucoadhesive beads of metformin HCl. Int J Biol Macromol 59:264–272

    Article  CAS  Google Scholar 

  • Nayak AK, Pal D (2014) Trigonella foenum-graecum L. seed mucilage-gellan mucoadhesive beads for controlled release of metformin HCl. Carbohydr Polym 107:31–40

    Article  CAS  Google Scholar 

  • Nayak AK, Pal D (2016) Plant-derived polymers: Ionically gelled sustained drug release systems, In: Mishra M (ed) Encyclopedia of biomedical polymers and polymeric biomaterials, Vol III. Taylor & Francis Group, U.S.A., pp 6002–6017

    Google Scholar 

  • Nayak AK, Pal D (2017a) Natural starches-blended ionotropically-gelled micrparticles/beads for sustained drug release, In: Thakur VK, Thakur MK, Kessler MR (eds) Handbook of composites from renewable materials, Volume 8, Nanocomposites: advanced applications. WILEY-Scrivener, USA, pp 527–560

    Google Scholar 

  • Nayak AK, Pal D (2017) Tamarind seed polysaccharide: An emerging excipient for pharmaceutical use. Indian J Pharm Educ Res 51:S136–S146

    Article  CAS  Google Scholar 

  • Nayak AK, Pal D (2018) Functionalization of tamarind gum for drug delivery, In: Thakur VK, Thakur MK (eds) Functional biopolymers. Springer International Publishing, Switzerland, pp 35–56

    Google Scholar 

  • Nayak AK, Pal D, Das S (2013) Calcium pectinate-fenugreek seed mucilage mucoadhesive beads for controlled delivery of metformin HCl. Carbohydr Polym 96:349–357

    Article  CAS  Google Scholar 

  • Nayak AK, Pal D, Hasnain MS (2013) Development, optimization and in vitro-in vivo evaluation of pioglitazone-loaded jackfruit seed starch-alginate beads. Curr Drug Deliv 10:608–619

    Article  CAS  Google Scholar 

  • Nayak AK, Pal D, Malakar J (2013) Development, optimization and evaluation of emulsion-gelled floating beads using natural polysaccharide-blend for controlled drug release. Polym Eng Sci 53:338–350

    Article  CAS  Google Scholar 

  • Nayak AK, Pal D, Pany DR, Mohanty B (2010) Evaluation of Spinacia oleracea L. leaves mucilage as innovative suspending agent. J Adv Pharm Technol Res 1:338–341

    Article  CAS  Google Scholar 

  • Nayak AK, Pal D, Pradhan J (2012) Ghorai T (2012) The potential of Trigonella foenum-graecum L. seed mucilage as suspending agent. Indian J Pharm Educ Res 46:312–317

    Google Scholar 

  • Nayak AK, Pal D, Pradhan J, Hasnain MS (2013) Fenugreek seed mucilage-alginate mucoadhesive beads of metformin HCl: design, optimization and evaluation. Int J Biol Macromol 54:144–154

    Article  CAS  Google Scholar 

  • Nayak AK, Pal D, Santra K (2014a) Development of pectinate-ispagula mucilage mucoadhesive beads of metformin HCl by central composite design. Int J Biol Macromol 66:203–221

    Article  CAS  Google Scholar 

  • Nayak AK, Pal D, Santra K (2014b) Development of calcium pectinate-tamarind seed polysaccharide mucoadhesive beads containing metformin HCl. Carbohydr Polym 101:220–230

    Article  CAS  Google Scholar 

  • Nayak AK, Pal D, Santra K (2014c) Ispaghula mucilage-gellan mucoadhesive beads of metformin HCl: Development by response surface methodology. Carbohydr Polym 107:41–50

    Article  CAS  Google Scholar 

  • Nayak AK, Pal D, Santra K (2014d) Tamarind seed polysaccharide-gellan mucoadhesive beads for controlled release of metformin HCl. Carbohydr Polym 103:154–163

    Article  CAS  Google Scholar 

  • Nayak AK, Pal D, Santra K (2014e) Artocarpus heterophyllus L. seed starch-blended gellan gum mucoadhesive beads of metformin HCl. Int J Biol Macromol 65:329–339

    Article  CAS  Google Scholar 

  • Nayak AK, Pal D, Santra K (2015) Screening of polysaccharides from tamarind, fenugreek and jackfruit seeds as pharmaceutical excipients. Int J Biol Macromol 79:756–760

    Article  CAS  Google Scholar 

  • Nayak AK, Pal D, Santra K (2016) Swelling and drug release behavior of metformin HCl-loaded tamarind seed polysaccharide-alginate beads. Int J Biol Macromol 82:1023–1027

    Article  CAS  Google Scholar 

  • Nazim S, Dehghan MHG, Shaikh S, Shaikh A (2011) Studies on hydrotrope potato starch gel as topical carrier for rofecoxib. Der Pharm Sin 2:227–235

    CAS  Google Scholar 

  • Nerkar PP, Gattani S (2011) In vivo, in vitro evaluation of linseed mucilage based buccal mucoadhesive microspheres of venlafaxine. Drug Deliv 18:111–121

    Article  CAS  Google Scholar 

  • Newton AMJ, Indana VL, Kumar J (2015) Chronotherapeutic drug delivery of tamarind gum, chitosan and okra gum controlled release colon targeted directly compressed propranolol HCl matrix tablets and in vitro evaluation. Int J Biol Macromol 79:290–299

    Article  CAS  Google Scholar 

  • Odeku OA, Fell JT (2005) In vitro evaluation of khaya and Albizia gums as compression coatings for drug targeting to the colon. J Pharm Pharmacol 57:163–168

    Article  CAS  Google Scholar 

  • Ofori-Kwakye K, Mfoafo KA, Kipo SL, Kuntworbe N, Boakye-Gyasi ME (2016) Development and evaluation of natural gum-based extended release matrix tablets of two model drugs of different water solubilities by direct compression. Saudi Pharm J 24:82–91

    Article  Google Scholar 

  • Ogaji I (2011) Some physicochemical properties of acetaminophen pediatric suspensions formulated with okra gums obtained from different extraction process as suspending agent. Asian J Pharm 5:15–20

    Article  CAS  Google Scholar 

  • Ogaji IJ, Hoang SW (2011) Effect of grewia gum as a suspending agent on ibuprofen pediatric formulation. AAPS PharmSciTech 12:507–513

    Article  CAS  Google Scholar 

  • Okunlola A, Odeku OA (2011) Evaluation of starches obtained from four Dioscorea species as binding agent in chloroquine phosphate tablet formulations. Saudi Pharm J 19:95–105

    Article  CAS  Google Scholar 

  • Pachuau L, Mazumdar B (2012) Albizia procera gum as an excipient for oral controlled release matrix tablets. Carbohydr Polym 90:284–295

    Article  CAS  Google Scholar 

  • Pal D, Chandra P, Sachan N, Hasnain MS, Nayak AK (2019b) Pharmaceutical applications of fenugreek seed gum. In: Nayak AK, Hasnain MS, Pal D (eds) Natural polymers for pharmaceutical applications, Vol. I: plant derived polymers, Apple Academic Press, USA, pp.203–226.

    Google Scholar 

  • Pal D, Nayak AK (2012) Novel tamarind seed polysaccharide-alginate mucoadhesive microspheres for oral gliclazide delivery. Drug Deliv 19:123–131

    Article  CAS  Google Scholar 

  • Pal D, Nayak AK (2017) Plant polysaccharides-blended ionotropically-gelled alginate multiple-unit systems for sustained drug release, In: Thakur VK, Thakur MK, Kessler MR (eds) Handbook of composites from renewable materials, volume 6, polymeric composites. WILEY-Scrivener, USA, pp 399–400

    Google Scholar 

  • Pal D, Nayak AK, Kalia K (2010) Studies on Basella alba L. leaves mucilage: Evaluation of suspending properties. Int J Drug Discov Technol 1:15–20

    Google Scholar 

  • Pal D, Nayak AK, Saha S (2019) Cellulose-based hydrogels: present and future. In: Akhtar MS Swamy MK Sinniah UR (eds) Natural bio-active compounds. Springer, Singapore, pp 285–332

    Google Scholar 

  • Panda D, Si S, Swain S, Kanungo SK, Gupta R (2006) Preparation and evaluation of gels from gum of Moringa oleifera. Indian J Pharm Sci 68:777–780

    Article  CAS  Google Scholar 

  • Peerapattana J, Laovachirasuwan P, Sodata P, Srijesdaruk V, Otsuka M (2020) Evaluation of using spray-dried glutinous rice starch as a direct compression hydrophilic matrix tablet. Biomed Mater Eng. https://doi.org/10.3233/BME-201080

    Article  Google Scholar 

  • Piriyaprasarth S, Patomchaiviwat V, Sriamornsak P, Seangpongchawal N, Katewongsa P, Akeuru P, Srijarreon P, Suttiphratya P (2010) Evaluation of yam (Dioscorea sp.) starch and arrowroot (Maranta arundinacea) starch as suspending agent in suspension. Adv Mater Res 93–94:362–365

    Article  CAS  Google Scholar 

  • Pitombeira NAO, Veras Neto JG, Silva DA, Feitosa JPA, Paula HCB, dePaula RCM (2015) Self-assembled nanoparticles of acetylated cashew gum: characterization and evaluation as potential drug carrier. Carbohydr Polym 117:610–615

    Article  CAS  Google Scholar 

  • Porto BC, Cristianini M (2014) Evaluation of cashew tree gum (Anacardium occidentale L.) emulsifying properties. LWT Food Sci Technol 59:1325–1331

    Article  CAS  Google Scholar 

  • Prajapati VD, Jani GK, Moradiya NG, Randeria NP (2013) Pharmaceutical applications of various natural gums, mucilages and their modified forms. Carbohydr Polym 92:1685–1699

    Article  CAS  Google Scholar 

  • Rana V, Rai P, Tiwary AK, Singh RS, Kennedy JF, Knill CJ (2011) Modified gums: Approaches and applications in drug delivery. Carbohydr Polym 83:1031–1047

    Article  CAS  Google Scholar 

  • Rao GC, Prasad PG, Srinivas K, Rao MF (2005) Application of Moringa oleifera as a suspending agent in the formulation of sulphamethoxazole. Indian Pharmacist 5:75–77

    Google Scholar 

  • Rao KM, Gnanaprakash K, Badrinath AV, Chetty CM, Alagusundaram M (2010) Preparation and evaluation of flurbiprofen gel: mucilage of Cocculas hirsutus leaf powder as gel base. Int J PharmTech Res 2:1578–1583

    CAS  Google Scholar 

  • Sachan NK, Bhattyacharya A (2009) Feasibility of Assam bora rice based matrix microdevices for controlled release of water insoluble drug. Int J Pharm Pharmaceut Sci 1:96–102

    CAS  Google Scholar 

  • Sadrjavadi K, Shahbazi B, Fattahi A (2018) De-esterified tragacanth-chitosan nano-hydrogel for methotrexate delivery; optimization of the formulation by Taguchi design. Artif Cells Nanomed Biotechnol 46(sup2):883–893

    Article  CAS  Google Scholar 

  • Sahu BP, Sharma HK, Das MK (2011) Development and evaluation of a mucoadhesive nasal gel of felodipine prepared with mucoadhesive substance of Dillenia indica L. Asian J Pharm Sci 5:175–187

    CAS  Google Scholar 

  • Samanta A, De A, Hasnain MS, Bera H, Nayak AK (2019) Gum odina as pharmaceutical excipient. In: Hasnain MS, Nayak AK, (eds) Natural polysaccharides in drug delivery and biomedical applications. Academic Press, Elsevier Inc., pp 327–337

    Google Scholar 

  • Samanta A, Ojha D, Mukherjee B (2010) Stability analysis of primary emulsion using a new emulsifying agent gum odina. Nat Sci 2:494–505

    CAS  Google Scholar 

  • Sinha Mahapatra S, Mohanta S, Nayak AK (2011) Preliminary investigation on angiogenic potential of Ziziphus oenoplia M. root ethanolic extract by chorioallantoic membrane model. Sci Asia 37:72–74

    Article  Google Scholar 

  • Sinha P, Ubaidulla U, Hasnain MS, Nayak AK, Rama B (2015) Alginate-okra gum blend beads of diclofenac sodium from aqueous template using ZnSO4 as a cross-linker. Int J Biol Macromol 79:555–563

    Article  CAS  Google Scholar 

  • Sinha P, Ubaidulla U, Nayak AK (2015) Okra (Hibiscus esculentus) gum-alginate blend mucoadhesive beads for controlled glibenclamide release. Int J Biol Macromol 72:1069–1075

    Article  CAS  Google Scholar 

  • Sinha VR, Al-Azaki AA, Kumar RV (2011) Novel Lannea Woodier gum matrices for controlled release of drugs. Carbohydr Polym 83:1492–1498

    Article  CAS  Google Scholar 

  • Soumya RS, Ghosh S, Abraham ET (2010) Preparation and characterization of guar gum nanoparticles. Int J Biol Macromol 46:267–269

    Article  CAS  Google Scholar 

  • Srivastava P, Malaviya R, Kulkarni GT (2010) Formulation and evaluation of paracetamol tablets to access binding property of orange peel pectin. Int J Pharm Sci Rev Res 3:982–996

    Google Scholar 

  • Sukhavasi S, Kishore VS (2012) Formulation and evaluation of fast dissolving tablets of amlodipine besylate by using fenugreek seed mucilage and Ocimum basilicum gum. Int Curr Pharm J 1:243–249

    Article  CAS  Google Scholar 

  • Tan C, Xie J, Zhang X, Cai J, Xia S (2016) Polysaccharide-based nanoparticles by chitosan and gum Arabic polyelectrolyte complexation as carriers for curcumin. Food Hydrocolloids 57:236–245

    Article  CAS  Google Scholar 

  • Verma PRP, Razdan B (2003) Studies on Leucaena leucocephala seed gum: Emulsifying properties. J Sci Ind Res 62:198–206

    CAS  Google Scholar 

  • Vivekanandan K, Gunasekaran V, Jayabalan G (2015) Design and evaluation of colon specific drug delivery of budenoside. Int J Pharm Pharm Sci 7:261–263

    Google Scholar 

  • Xie JH, Jin ML, Morris GA, Zha XQ, Chen HQ, Yi Y, Li JE, Wang ZJ, Gao J, Nie SP, Shang P, Xie MY (2016) Advances on bioactive polysaccharides from medicinal plants. Crit Rev Food Sci Nutr 56(Suppl 1):S60-84

    Article  CAS  Google Scholar 

  • Zhao Y, Khalid N, Shu G, Neves MA, Kobayashi I, Nakajima M (2017) Formulation and characterization of oil-in-water emulsions stabilized by gelatinized kudzu starch. Int J Food Prop 20:1329–1341

    CAS  Google Scholar 

  • Zhou W, Liu W, Zou L, Liu W, Liu C, Liang R, Chen J (2014) Storage stability and skin permeation of vitamin C liposomes improved by pectin coating. Colloids Surf B Biointerf 117:330–337

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Pharmaceutics, Seemanta Institute of Pharmaceutical Sciences, Mayurbhanj, Odisha, 757086, India

    Amit Kumar Nayak

  2. Department of Pharmacy, Shri Venkateshwara University, Gajraula, Amroha, UP, India

    Md Saquib Hasnain

  3. Department of Pharmacy, Contai Polytechnic, Darua, Contai, Purba Medinipur, West Bengal, 721406, India

    Amal Kumar Dhara

  4. Department of Pharmaceutical Sciences, Guru Ghasidas Vishwavidyalaya (A Central University), Koni, Bilaspur, C.G, 495009, India

    Dilipkumar Pal

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  1. Amit Kumar Nayak
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  3. Amal Kumar Dhara
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  4. Dilipkumar Pal
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  1. Institute of Pharmaceutical Sciences, Guru Ghasidas Vishwavidyalaya (A Central University), Bilaspur, Chhattisgarh, India

    Dilipkumar Pal

  2. Department of Pharmaceutics, Seemanta Institute of Pharmaceutical Science, Mayurbhanj, Odisha, India

    Amit Kumar Nayak

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Nayak, A.K., Hasnain, M.S., Dhara, A.K., Pal, D. (2021). Plant Polysaccharides in Pharmaceutical Applications. In: Pal, D., Nayak, A.K. (eds) Bioactive Natural Products for Pharmaceutical Applications. Advanced Structured Materials, vol 140. Springer, Cham. https://doi.org/10.1007/978-3-030-54027-2_3

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