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Immunity and Health

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Explaining Health Across the Sciences

Part of the book series: Healthy Ageing and Longevity ((HAL,volume 12))

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Abstract

Health is very difficult to define. In 1948 the WHO tried to conceptualise health, which was in its time revolutionary. This was slightly amended in 1986 by introducing a new approach and concepts. However, many authors from various scientific horizons criticized this definition and tried to give an alternative. One alternative is that of a dynamic process which contributes to a functional and complete life. This state of health should be maintained at each moment of life and we argue that immunity is meant to play this role by protecting an organism from external (pathogen, injury) or internal (cancerous transformation of the cells) challenges. It is in fact destined to do so during the entire lifespan and its dwindling capability to neutralize challenges results in a shortening of the lifespan. However, the constant challenges by environmental and endogenous pathogens/stressors to the immune system may dysregulate it and lead to chronic inflammation underlying most of the modern chronic diseases. This dysregulation may be avoided or reset largely thanks to a healthy lifestyle. Thus, health and immunity are intricately linked and it is important to understand the interactions to boost the immune system for sustaining health.

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Acknowledgments

This work was supported by grants from Canadian Institutes of Health Research (CIHR) (No. 106634), the Société des médecins de l’Université de Sherbrooke and the Research Center on Aging of the CIUSSS-CHUS, Sherbrooke, by the Polish Ministry of Science and Higher Education statutory grant 02–0058/07/262 to JMW and by Agency for Science Technology and Research (A*STAR) to AL.

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Authors and Affiliations

  1. Department of Geriatrics, Faculty of Medicine, Research Center on Aging, University of Sherbrooke, Sherbrooke, QC, J1K 2R1, Canada

    T. Fülöp

  2. Department of Family Medicine, Faculty of Medicine, Research Center on Aging, University of Sherbrooke, Sherbrooke, QC, J1K 2R1, Canada

    A. A. Cohen

  3. Biology of Aging Program and Immunomonitoring Platform, Singapore Immunology Network (SIgN), Agency for Science Technology and Research (A*STAR), Immunos Building, Biopolis, 138648, Singapore

    A. Larbi

  4. Department of Pathophysiology, Medical University of Gdansk, Gdansk, Poland

    J. M. Witkowski

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  1. T. Fülöp
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  2. A. A. Cohen
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  3. A. Larbi
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  4. J. M. Witkowski
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Correspondence to T. Fülöp .

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Editors and Affiliations

  1. Philosophy and History of Ideas, Aarhus University, Aarhus, Denmark

    Jonathan Sholl

  2. Department of Molecular Biology and Genetics, Aarhus University, Aarhus, Denmark

    Suresh I.S. Rattan

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Fülöp, T., Cohen, A.A., Larbi, A., Witkowski, J.M. (2020). Immunity and Health. In: Sholl, J., Rattan, S.I. (eds) Explaining Health Across the Sciences. Healthy Ageing and Longevity, vol 12. Springer, Cham. https://doi.org/10.1007/978-3-030-52663-4_13

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