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A Brief Overview of Progranulin in Health and Disease

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Progranulin

Part of the book series: Methods in Molecular Biology ((MIMB,volume 1806))

Abstract

The purpose of this brief overview of the progranulin protein is to provide a sense of the range and extent of the roles of progranulin in normal physiology and pathology. Progranulin has received attention due to its role in neurodegeneration, where mutation of a single copy of GRN, the gene encoding progranulin, results in frontotemporal dementia, whereas viral delivery of progranulin to the brains of mice exhibiting Parkinson’s or Alzheimer’s disease phenotypes inhibits the progression of the neurodegenerative phenotypes. Of equal importance, progranulin protects tissues against the harmful effects of poorly controlled inflammation and promotes tissue regeneration after injury at a multitude of sites throughout the body. Progranulin is overexpressed by many types of cancer and contributes to their progression. Given suitable analytical methods and model systems, progranulin offers a wealth of research possibilities.

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Authors and Affiliations

  1. Department of Medicine, McGill University, Montreal, QC, Canada

    Andrew Bateman & Hugh P. J. Bennett

  2. Program in Metabolic Diseases and Their Complications, Centre for Translational Biology, Research Institute of McGill University Health Centre, Montreal, QC, Canada

    Andrew Bateman & Hugh P. J. Bennett

  3. Department of Surgery, The Chinese University of Hong Kong, Hong Kong, China

    Siu Tim Cheung

  4. Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong, China

    Siu Tim Cheung

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  1. Andrew Bateman
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  2. Siu Tim Cheung
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  3. Hugh P. J. Bennett
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Correspondence to Andrew Bateman .

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Editors and Affiliations

  1. Department of Medicine, McGill University MUHC, Montreal, Québec, Canada

    Andrew Bateman

  2. Department of Medicine, McGill University MUHC, Montreal, Québec, Canada

    Hugh P.J. Bennett

  3. Department of Surgery, The Chinese University of Hong Kong, Hong Kong, China

    Siu Tim Cheung

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Bateman, A., Cheung, S.T., Bennett, H.P.J. (2018). A Brief Overview of Progranulin in Health and Disease. In: Bateman, A., Bennett, H., Cheung, S. (eds) Progranulin. Methods in Molecular Biology, vol 1806. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-8559-3_1

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  • DOI: https://doi.org/10.1007/978-1-4939-8559-3_1

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  • Publisher Name: Humana Press, New York, NY

  • Print ISBN: 978-1-4939-8557-9

  • Online ISBN: 978-1-4939-8559-3

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