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Practical Approaches in M2 Macrophage Biology: Analysis, Pharmacology, and Didactical Interpretation of M2 Macrophage Functions

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The M2 Macrophage

Part of the book series: Progress in Inflammation Research ((PIR,volume 86))

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  • The original version of this chapter was revised: The original version of this chapter was inadvertently published with incomplete captions of Figs. 6 and 7 which has been updated now. The correction to this chapter is available at https://doi.org/10.1007/978-3-030-50480-9_11

Abstract

This chapter overviews the practical aspects of M2 macrophage analysis, such as the work with various types of macrophages and the choice and analysis of M2 marker mRNA and proteins. M2 macrophages have biomedical impact, and pharmacological reprogramming of macrophage activation has gained attention in the past decade. In certain diseases the induction of M2 activation is a desired therapeutic aim, most importantly in metabolic diseases, where promoting M2 activation within metabolic organs is a tool to reduce chronic inflammation. Although inducing an M2 macrophage state is desired in chronic inflammatory diseases, the restoration of anticancer immunity requires the blockage of M2 activation. The pharmacology of M2 macrophage activation, and inhibition of M2 macrophage functions, are overviewed in this chapter. Finally, some didactic approaches are shown that have practical application in interpreting M2 macrophage functions and in aiding scientific communication and university teaching of the theory of M2 macrophage biology.

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Change history

  • 17 September 2020

    The original version of chapter 10 in this book was inadvertently published with incomplete captions of Figs. 6 and 7. 8. The figure captions have now been corrected – image courtesy details are added at the end of the captions as given below.

Notes

  1. 1.

    William Shakespeare: Romeo and Juliet, Act 2, Scene 3, monologue of Friar Lawrence.

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  1. Institute of Neurobiology, Ulm University, Ulm, Baden-Württemberg, Germany

    Tamás Röszer

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Röszer, T. (2020). Practical Approaches in M2 Macrophage Biology: Analysis, Pharmacology, and Didactical Interpretation of M2 Macrophage Functions. In: The M2 Macrophage. Progress in Inflammation Research, vol 86. Springer, Cham. https://doi.org/10.1007/978-3-030-50480-9_10

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