Abstract
Nuclear cardiology imaging is solidly based on many branches of science and engineering, including nuclear, optical, and mathematical physics; electrical and mechanical engineering; chemistry; and biology. This chapter uses principles from these scientific fields to provide an understanding of both the signals used and the imaging system that captures these signals. These principles have been simplified to fit the scope of this atlas.
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References
Chandra R. Introductory physics of nuclear medicine. Philadelphia: Lea and Febiger; 1992.
Christensen EE, Curry TS, Dowdey JE. An introduction to the physics of diagnostic radiology. 2nd ed. Philadelphia: Lea and Febiger; 1978. p. 159.
Powsner RA, Powsner ER. Essentials of nuclear medicine physics. Malden: Blackwell Science; 1998.
Hubble JH, Seltzer SM. Tables of x-ray mass attenuation coefficients, and mass energy-absorption coefficients. Gaithersburg: National Institute of Standards and Technology; 1996. Available at: http://physics.nist.gov/PhysRefData/XrayMassCoef/tab1.html. Accessed Jul 2018.
Cherry SR, Sorenson JA, Phelps ME. Physics in nuclear medicine. Philadelphia: WB Saunders; 2003.
Beller GA, Bergmann SR. Myocardial perfusion imaging agents: SPECT and PET. J Nucl Cardiol. 2004;11:71–86.
Saha GB. Fundamentals of nuclear pharmacy. New York: Springer; 2003.
Anger HO. Scintillation camera with multichannel collimators. J Nucl Med. 1964;5:515–31.
Maublant JC, Peycelon P, Kwiatkowski F, Lusson JR, Standke RH, Veyre A. Comparison between 180° and 360° data collection in technetium-99m MIBI SPECT of the myocardium. J Nucl Med. 1989;30:295–300.
Hoffman EJ. 180° compared to 360° sampling in SPECT. J Nucl Med. 1982;23:745–6.
Knesaurek K, King MA, Glick SJ, Penney BC. Investigation of causes of geometric distortion in 180° and 360° angular sampling in SPECT. J Nucl Med. 1989;30:1666–75.
Garcia EV, Galt JR, Cullom SJ, Faber TL. Principles of myocardial perfusion SPECT imaging. North Billerica: DuPont Pharma; 1994. p. 30.
Galt JR, Garcia EV, Robbins WL. Effects of myocardial wall thickness on SPECT quantification. IEEE Trans Med Imaging. 1990;9:144–50.
Shepp LA, Vardi Y. Maximum likelihood reconstruction for emission tomography. IEEE Trans Med Imaging. 1982;1:113–22.
Hudson HM, Larkin RS. Accelerated image reconstruction using ordered subsets of projection data. IEEE Trans Med Imaging. 1994;13:601–9.
Jaszczak RJ, Greer KL, Floyd CE Jr, Harris CC, Coleman RE. Improved SPECT quantification using compensation for scattered photons. J Nucl Med. 1984;25:893–900.
Ogawa K, Ichihara T, Kubo A. Accurate scatter correction in single photon emission CT. Ann Nucl Med Sci. 1994;7:145–50.
Glick SJ, Penney BC, King MA, Byrne CL. Noniterative compensation for the distance-dependent detector response and photon attenuation in SPECT imaging. IEEE Trans Med Imaging. 1994;13:363–74.
Zeng GL, Gullberg GT, Tsui BM, et al. Three-dimensional iterative reconstruction algorithms with attenuation and geometric point response correction. IEEE Trans Med Imaging. 1990;22:1475–9.
Smith WH, Kastner RJ, Calnon DA, Segalla D, Beller GA, Watson DD. Quantitative gated single-photon emission computed tomography imaging: a counts-based method for display and measurement of regional and global ventricular systolic function. J Nucl Cardiol. 1997;4:451–63.
Machac J, Chen H, Almeida OD, et al. Comparison of 2D and high dose and low dose 3D gated myocardial Rb-82 PET imaging [abstract]. J Nucl Med. 2002;43:777.
Karp JS, Surti S, Daube-Witherspoon ME, Muehllehner G. Benefit of Time-of-Flight in PET: Experimental and clinical results. J Nucl Med. 2008;49(3):462–70.
Schaart DR, van Dam HT, Seifert S, Vinke R, Dendoover P, Lohner H, Beekman FJ. SiPM-Array Based PET detectors with depth-of-interaction correction. IEEE Nuc Sci Symposium Conference Record. 2008:3581–5.
Schelbert HR, Beanlands R, Bengel F, Knuuti J, Dicarli M, Machac J, Patterson R. PET myocardial perfusion and glucose metabolism imaging: Part 2-Guidelines for interpretation and reporting. J Nucl Cardiol. 2003;10:557–71.
Dorbala S, Ananthasubramaniam K, Armstrong IS, Chareonthaitawee P, DePuey EG, Einstein AJ, et al. Single photon emission computed tomography (SPECT) myocardial perfusion imaging guidelines: instrumentation, acquisition, processing, and interpretation. J Nucl Cardiol. 2018;25(5):1784–46.
Nichols KJ, Galt JR. Quality control for SPECT imaging. In: DePuey EG, Garcia EV, Berman DS, editors. Cardiac SPECT imaging. 2nd ed. New York: Lippincott Williams & Wilkins; 2001. p. 17–39.
DePuey EG. Artifacts in SPECT myocardial perfusion imaging. In: DePuey EG, Garcia EV, Berman DS, editors. Cardiac SPECT imaging. 2nd ed. New York: Lippincott Williams & Wilkins; 2001. p. 349.
DePuey EG, Garcia EV. Optimal specificity of thallium-201 SPECT through recognition of imaging artifacts. J Nucl Med. 1989;30:441–9.
Geckle WJ, Frank YL, Links JM, Becker LC. Correction for patient motion and organ movement in SPECT: application to exercise thallium-201 cardiac imaging. J Nucl Med. 1988;29:441–50.
Di Carli MF, Hachamovich R. New technology for noninvasive evaluation of coronary artery disease. Circulation. 2007;115:1464–80.
Faber TL, Santana CA, Garcia EV, Candell-Riera J, Folks RD, Peifer JW, et al. Three-dimensional fusion of coronary arteries with myocardial perfusion distributions: clinical validation. J Nucl Med. 2004;45:745–53.
Rispler S, Keidar Z, Ghersin E, Roguin A, Soil A, Dragu R, et al. Integrated single-photon emission computed tomography and computed tomography coronary angiography for the assessment of hemodynamically significant coronary artery lesions. J Am Coll Cardiol. 2007;49:1059–67.
Santana CA, Garcia EV, Faber TL, Sirineni GK, Esteves FP, Sanyal R, et al. Diagnostic performance of fusion of myocardial perfusion and computed tomography coronary angiography. J Nucl Cardiol. 2009;16:201–11.
Gaemperli O, Schepis T, Valenta I, Husmann L, Scheffel H, Duerst V, et al. Cardiac image fusion from stand-alone SPECT and CT: clinical experience. J Nucl Med. 2007;48:696–703.
Faber TL, Arepalli CD, Nye JA, et al. Second generation fusion of myocardial perfusion distributions with coronary artery data from CT angiography. J Nucl Cardiol. 2010;17(4):724–722 (abstr).
Garcia EV, Faber TL. New trends in camera and software technology in nuclear cardiology. Cardiol Clin. 2009;27:227–36.
Garcia EV, Faber TL, Esteves FP. Cardiac dedicated ultrafast SPECT cameras: new designs and clinical implications. J Nucl Med. 2011;52:210–7.
Borges-Neto S, Pagnanelli RA, Shaw LK, Honeycutt E, Shwartz SC, Adams GL, Coleman RE. Clinical results of a novel wide beam reconstruction method for shortening scan time of Tc-99m cardiac SPECT perfusion studies. J Nucl Cardiol. 2007;14:555–65.
DePuey EG, Gadiraju R, Clark J, Thompson L, Anstett F, Shwartz SC. Ordered subset expectation maximization and wide beam reconstruction “half-time” gated myocardial perfusion SPECT functional imaging: a comparison to “full-time” filtered backprojection. J Nucl Cardiol. 2008;15:547–63.
Sharir T, Slomka PJ, Berman DS. Solid-state SPECT technology: fast and furious. J Nucl Cardiol. 2010;17:890–6.
Maddahi J, Mendez R, Mahmarian J, Thomas G, Babla H, Bai C, et al. Prospective multi-center evaluation of rapid gated SPECT myocardial perfusion upright imaging. J Nucl Cardiol. 2009;16:351–7.
Sharir T, Ben-Haim S, Merzon K, Prochorov V, Dickman D, Ben-Haim S, Berman DS. High-speed myocardial perfusion imaging: initial clinical comparison with conventional dual detector anger camera imaging. JACC Cardiovasc Imaging. 2008;1:156–63.
Sharir T, Slomka PJ, Hayes SW, DiCarli MF, Ziffer JA, Martin WH, et al. Multicenter trial of high-speed versus conventional single-photon emission computed tomography imaging: quantitative results of myocardial perfusion and left ventricular function. J Am Coll Cardiol. 2010;55:1965–74.
Ben-Haim S, Hutton BF, Van Grantberg D. Simultaneous dual-radionuclide myocardial perfusion imaging with a solid-state dedicated cardiac camera. Eur J Nucl Med Mol Imaging. 2010;37:1710–21.
Garcia EV, Tsukerman L, Keidar Z. A new solid state ultra fast cardiac multi-detector SPECT system. J Nucl Cardiol. 2008;15:S3 (abstr).
Esteves FP, Raggi P, Folks RD, Keidar Z, Askew JW, Rispler S, et al. Novel solid-state-detector dedicated cardiac camera for fast myocardial perfusion imaging: multicenter comparison with standard dual detector cameras. J Nucl Cardiol. 2009;16:927–34.
Buechel RR, Herzog BA, Husmann L, Burger IA, Pazhenkottil AP, Treyer V, et al. Ultrafast nuclear myocardial perfusion imaging on a new gamma camera with semiconductor detector technique: first clinical validation. Eur J Nucl Med Mol Imaging. 2010;37:773–8.
Herzog BA, Buechel RR, Katz R, Brueckner M, Husmann L, Burger IA, et al. Nuclear myocardial perfusion imaging with a cadmium-zinc-telluride detector technique: optimized protocol for scan time reduction. J Nucl Med. 2010;51:46–51.
Cerqueira MD, Allman KC, Ficaro EP, Hansen CL, Nichols KJ, Thompson RC, et al. Recommendations for reducing radiation exposure in myocardial perfusion imaging. J Nucl Cardiol. 2010;17:709–18.
Herzog BA, Buechel RR, Husmann L, Pazhenkottil AP, Burger IA, Wolfrum M, et al. Validation of CT attenuation correction for high-speed myocardial perfusion imaging using a novel cadmium-zinc-telluride detector technique. J Nucl Med. 2010;51:1539–44.
Pazhenkottil AP, Husmann L, Kaufmann PA. Cardiac hybrid imaging with high-speed single-photon emission computed tomography/CT camera to detect ischaemia and coronary artery obstruction. Heart. 2010;96:2050. https://doi.org/10.1136/hrt.2010.201996.
Gremillet E, Agostini D. How to use cardiac IQ•SPECT routinely? An overview of tips and tricks from practical experience to the literature. Eur J Nucl Med Mol Imaging. 2016;43:707–10.
Lyon MC, Foster C, Ding X, Dorbala S, Spence D, Bhattacharya M, et al. Dose reduction in half-time myocardial perfusion SPECT-CT with multifocal collimation. J Nucl Cardiol. 2016;23:657–67.
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Garcia, E.V., Galt, J.R., Piccinelli, M., Chen, J. (2021). Principles of Nuclear Cardiology Imaging. In: Dilsizian, V., Narula, J. (eds) Atlas of Nuclear Cardiology. Springer, Cham. https://doi.org/10.1007/978-3-030-49885-6_2
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DOI: https://doi.org/10.1007/978-3-030-49885-6_2
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