Skip to main content

Severe Respiratory Failure: ARDS and ECMO

  • Chapter
  • First Online:
Echography and Doppler of the Brain

Abstract

Respiratory complications are common in patients with acute brain injury and represent a significant challenge from both a respiratory and a neurological perspective. Commonly used ventilatory and non-ventilatory strategies may affect cerebral perfusion and oxygen delivery. The concomitant use of brain and general critical care ultrasound techniques aimed at monitoring cerebral perfusion and cardiorespiratory parameters at the bedside may offer a significant benefit in delivering both lung- and neuroprotective approaches in patients with complex ventilatory needs and deranged cerebrovascular physiology. In this chapter we discuss potential applications of ultrasonography for the management of patients with severe respiratory failure. Although appealing and physiologically sound, the use of ultrasound is currently supported by limited evidence and more data are needed to support its routine use in clinical practice.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

eBook
USD 16.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 69.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 109.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Rincon F, Ghosh S, Dey S, Maltenfort M, Vibbert M, Urtecho J, et al. Impact of acute lung injury and acute respiratory distress syndrome after traumatic brain injury in the United States. Neurosurgery. 2012;71(4):795–803.

    Article  PubMed  Google Scholar 

  2. Veeravagu A, Chen YR, Ludwig C, Rincon F, Maltenfort M, Jallo J, et al. Acute lung injury in patients with subarachnoid hemorrhage: a nationwide inpatient sample study. World Neurosurg. 2014;82(1):e235–41.

    Article  PubMed  Google Scholar 

  3. Esteban A, Frutos-Vivar F, Muriel A, Ferguson ND, Peñuelas O, Abraira V, et al. Evolution of mortality over time in patients receiving mechanical ventilation. Am J Respir Crit Care Med. 2013;188(2):220–30.

    Article  PubMed  Google Scholar 

  4. Wilcox ME, Brummel NE, Archer K, Ely EW, Jackson JC, Hopkins RO. Cognitive dysfunction in ICU patients: risk factors, predictors, and rehabilitation interventions. Crit Care Med. 2013;41(9 Suppl 1):S81–98.

    Article  PubMed  Google Scholar 

  5. Young N, Rhodes JKJ, Mascia L, Andrews PJD. Ventilatory strategies for patients with acute brain injury. Curr Opin Crit Care. 2010;16(1):45–52.

    Article  PubMed  Google Scholar 

  6. Corradi F, Robba C, Tavazzi G, Via G. Combined lung and brain ultrasonography for an individualized “brain-protective ventilation strategy” in neurocritical care patients with challenging ventilation needs. Crit Ultrasound J. 2018;10(1):24.

    Article  PubMed  PubMed Central  Google Scholar 

  7. Schramm P, Closhen D, Felkel M, Berres M, Klein KU, David M, et al. Influence of PEEP on cerebral blood flow and cerebrovascular autoregulation in patients with acute respiratory distress syndrome. J Neurosurg Anesthesiol. 2013;25(2):162–7.

    Article  PubMed  Google Scholar 

  8. Frisvold SK, Robba C, Guérin C. What respiratory targets should be recommended in patients with brain injury and respiratory failure? Intensive Care Med. 2019;45(5):683–6.

    Article  PubMed  Google Scholar 

  9. Caricato A, Conti G, Della Corte F, Mancino A, Santilli F, Sandroni C, et al. Effects of PEEP on the intracranial system of patients with head injury and subarachnoid hemorrhage: the role of respiratory system compliance. J Trauma – Inj Infect Crit Care. 2005;58(3):571–6.

    Article  Google Scholar 

  10. Mascia L, Grasso S, Fiore T, Bruno F, Berardino M, Ducati A. Cerebro-pulmonary interactions during the application of low levels of positive end-expiratory pressure. Intensive Care Med. 2005;31(3):373–9.

    Article  PubMed  Google Scholar 

  11. Mc Guire G, Crossley D, Richards J, Wong D. Effects of varying levels of positive end-expiratory pressure on intracranial pressure and cerebral perfusion pressure. Crit Care Med. 1997;25(6):1059–62.

    Article  CAS  Google Scholar 

  12. Muench E, Bauhuf C, Roth H, Horn P, Phillips M, Marquetant N, et al. Effects of positive end-expiratory pressure on regional cerebral blood flow, intracranial pressure, and brain tissue oxygenation. Crit Care Med. 2005;33(10):2367–72.

    Article  PubMed  Google Scholar 

  13. Nemer SN, Caldeira JB, Santos RG, Guimarães BL, Garcia JM, Prado D, et al. Effects of positive end-expiratory pressure on brain tissue oxygen pressure of severe traumatic brain injury patients with acute respiratory distress syndrome: a pilot study. J Crit Care. 2015;30(6):1263–6.

    Article  PubMed  Google Scholar 

  14. Robba C, Cardim D, Tajsic T, Pietersen J, Bulman M, Donnelly J, et al. Ultrasound non-invasive measurement of intracranial pressure in neurointensive care: a prospective observational study. PLoS Med. 2017;14(7):e1002356.

    Article  PubMed  PubMed Central  Google Scholar 

  15. Guérin C, Reignier J, Richard J-C, Beuret P, Gacouin A, Boulain T, et al. Prone positioning in severe acute respiratory distress syndrome. N Engl J Med. 2013;368(23):2159–68.

    Article  CAS  PubMed  Google Scholar 

  16. Roth C, Ferbert A, Deinsberger W, Kleffmann J, Kästner S, Godau J, et al. Does prone positioning increase intracranial pressure? A retrospective analysis of patients with acute brain injury and acute respiratory failure. Neurocrit Care. 2014;21(2):186–91.

    Article  PubMed  Google Scholar 

  17. Reinprecht A, Greher M, Wolfsberger S, Dietrich W, Illievich UM, Gruber A. Prone position in subarachnoid hemorrhage patients with acute respiratory distress syndrome: effects on cerebral tissue oxygenation and intracranial pressure. Crit Care Med. 2003;31(6):1831–8.

    Article  PubMed  Google Scholar 

  18. Robba C, Bragazzi NL, Bertuccio A, Cardim D, Donnelly J, Sekhon M, et al. Effects of prone position and positive end-expiratory pressure on noninvasive estimators of ICP: a pilot study. J Neurosurg Anesthesiol. 2017;29(3):243–50.

    Article  PubMed  Google Scholar 

  19. Luyt C-E, Bréchot N, Demondion P, Jovanovic T, Hékimian G, Lebreton G, et al. Brain injury during venovenous extracorporeal membrane oxygenation. Intensive Care Med. 2016;42(5):897–907.

    Article  PubMed  CAS  Google Scholar 

  20. Australia and New Zealand Extracorporeal Membrane Oxygenation (ANZ ECMO) Influenza Investigators, Davies A, Jones D, Bailey M, Beca J, Bellomo R, et al. Extracorporeal membrane oxygenation for 2009 influenza a(H1N1) acute respiratory distress syndrome. JAMA. 2009;302(17):1888–95.

    Article  Google Scholar 

  21. Kasirajan V, Smedira NG, McCarthy JF, Casselman F, Boparai N, McCarthy PM. Risk factors for intracranial hemorrhage in adults on extracorporeal membrane oxygenation. Eur J Cardiothorac Surg. 1999;15(4):508–14.

    Article  PubMed  CAS  Google Scholar 

  22. Sutter R, Tisljar K, Marsch S. Acute neurologic complications during extracorporeal membrane oxygenation: a systematic review. Crit Care Med. 2018;46(9):1506–13.

    Article  PubMed  CAS  Google Scholar 

  23. Rilinger JF, Smith CM, deRegnier RAO, Goldstein JL, Mills MG, Reynolds M, et al. Transcranial Doppler identification of neurologic injury during pediatric extracorporeal membrane oxygenation therapy. J Stroke Cerebrovasc Dis. 2017;26(10):2336–45.

    Article  PubMed  Google Scholar 

  24. Blanco P, Blaivas M. Applications of transcranial color-coded sonography in the emergency department. J Ultrasound Med. 2017;36(6):1251–66.

    Article  PubMed  Google Scholar 

  25. Mäurer M, Shambal S, Berg D, Woydt M, Hofmann E, Georgiadis D, et al. Differentiation between intracerebral hemorrhage and ischemic stroke by transcranial color-coded duplex-sonography. Stroke. 1998;29(12):2563–7.

    Article  PubMed  Google Scholar 

  26. Kukulska-Pawluczuk B, Ksiazkiewicz B, Nowaczewska M. Imaging of spontaneous intracerebral hemorrhages by means of transcranial color-coded sonography. Eur J Radiol. 2012;81(6):1253–8.

    Article  PubMed  Google Scholar 

  27. Niesen WD, Burkhardt D, Hoeltje J, Rosenkranz M, Weiller C, Sliwka U. Transcranial grey-scale sonography of subdural haematoma in adults. Ultraschall der Medizin. 2006;27(3):251–5.

    Article  Google Scholar 

  28. Llompart Pou JA, Abadal Centellas JM, Palmer Sans M, Pérez Bárcena J, Casares Vivas M, Homar Ramírez J, et al. Monitoring midline shift by transcranial color-coded sonography in traumatic brain injury: a comparison with cranial computerized tomography. Intensive Care Med. 2004;30(8):1672–5.

    Article  PubMed  Google Scholar 

  29. Tang SC, Huang SJ, Jeng JS, Yip PK. Third ventricle midline shift due to spontaneous supratentorial intracerebral hemorrhage evaluated by transcranial color-coded sonography. J Ultrasound Med. 2006;25(2):203–9.

    Article  PubMed  Google Scholar 

  30. Omar HR, Mirsaeidi M, Shumac J, Enten G, Mangar D, Camporesi EM. Incidence and predictors of ischemic cerebrovascular stroke among patients on extracorporeal membrane oxygenation support. J Crit Care. 2016;32:48–51.

    Article  PubMed  Google Scholar 

  31. Mehta A, Ibsen LM. Neurologic complications and neurodevelopmental outcome with extracorporeal life support. World J Crit Care Med. 2013;2(4):40–7.

    Article  PubMed  PubMed Central  Google Scholar 

  32. Ringelstein EB, Droste DW, Babikian VL, Evans DH, Grosset DG, Kaps M, et al. Consensus on microembolus detection by TCD: international consensus group on microembolus detection. Stroke. 1998;29(3):725–9.

    Article  PubMed  CAS  Google Scholar 

  33. Marinoni M, Migliaccio ML, Trapani S, Bonizzoli M, Gucci L, Cianchi G, et al. Cerebral microemboli detected by transcranial doppler in patients treated with extracorporeal membrane oxygenation. Acta Anaesthesiol Scand. 2016;60(7):934–44.

    Article  PubMed  CAS  Google Scholar 

  34. Fanelli V, Mazzeo AT, Battaglini I, Caccia S, Boffini M, Ricci D, et al. Cerebral autoregulation in patients treated with V-V ECMO for severe ARDS. Intensive Care Med Exp. 2015;3(Suppl 1):A509–3.

    Article  PubMed Central  Google Scholar 

  35. O’Brien NF, Hall MW. Extracorporeal membrane oxygenation and cerebral blood flow velocity in children. Pediatr Crit Care Med. 2013;14(3):e126–34.

    Article  PubMed  Google Scholar 

  36. Zamora CA, Oshmyansky A, Bembea M, Berkowitz I, Alqahtani E, Liu S, et al. Resistive index variability in anterior cerebral artery measurements during daily transcranial duplex sonography: a predictor of cerebrovascular complications in infants undergoing extracorporeal membrane oxygenation? J Ultrasound Med. 2016;35(11):2459–65.

    Article  PubMed  Google Scholar 

  37. Kredel M, Lubnow M, Westermaier T, Müller T, Philipp A, Lotz C, et al. Cerebral tissue oxygenation during the initiation of venovenous ECMO. ASAIO J. 2014;60(6):694–700.

    Article  PubMed  CAS  Google Scholar 

  38. Marinoni M, Cianchi G, Trapani S, Migliaccio ML, Bonizzoli M, Gucci L, et al. Retrospective analysis of transcranial doppler patterns in veno-arterial extracorporeal membrane oxygenation patients: feasibility of cerebral circulatory arrest diagnosis. ASAIO J. 2018;62(2):175–82.

    Article  Google Scholar 

  39. Hagen PT, Scholz DG, Edwards WD. Incidence and size of patent foramen ovale during the first 10 decades of life: an autopsy study of 965 normal hearts. Mayo Clin Proc. 1984;59(1):17–20.

    Article  PubMed  CAS  Google Scholar 

  40. Mekontso Dessap A, Boissier F, Leon R, Carreira S, Campo FR, Lemaire F, et al. Prevalence and prognosis of shunting across patent foramen ovale during acute respiratory distress syndrome. Crit Care Med. 2010;38(9):1786–92.

    Article  PubMed  Google Scholar 

  41. Boissier F, Razazi K, Thille AW, Roche-Campo F, Leon R, Vivier E, et al. Echocardiographic detection of transpulmonary bubble transit during acute respiratory distress syndrome. Ann Intensive Care. 2015;5:5.

    Article  PubMed  PubMed Central  Google Scholar 

  42. Tobe J, Bogiatzi C, Munoz C, Tamayo A, Spence JD. Transcranial Doppler is complementary to echocardiography for detection and risk stratification of patent foramen ovale. Can J Cardiol. 2016;32(8):986.

    Article  PubMed  Google Scholar 

  43. Vuković-Cvetković V. Microembolus detection by transcranial Doppler sonography: review of the literature. Stroke Res Treat. 2012;2012:382361.

    PubMed  Google Scholar 

  44. Legras A, Dequin PF, Hazouard E, Doucet O, Tranquart F, Perrotin D. Right-to-left interatrial shunt in ARDS: dramatic improvement in prone position. Intensive Care Med. 1999;25(4):412–4.

    Article  PubMed  CAS  Google Scholar 

  45. Lui JK, Banauch GI. Diagnostic bedside ultrasonography for acute respiratory failure and severe hypoxemia in the medical intensive care unit: basics and comprehensive approaches. J Intensive Care Med. 2016;32(6):355–72.

    Article  PubMed  Google Scholar 

  46. Goffi A, Kruisselbrink R, Volpicelli G. The sound of air: point-of-care lung ultrasound in perioperative medicine. Can J Anaesth. 2018;65(4):399–416.

    Article  PubMed  Google Scholar 

  47. Kruisselbrink R, Chan V, Cibinel GA, Abrahamson S, Goffi A. I-AIM (indication, acquisition, interpretation, medical decision-making) framework for point of care lung ultrasound. Anesthesiology. 2017;127(3):568–82.

    Article  PubMed  Google Scholar 

  48. Mayo PH, Copetti R, Feller-Kopman D, Mathis G, Maury E, Mongodi S, et al. Thoracic ultrasonography: a narrative review. Intensive Care Med. 2019;45(9):1200–11.

    Article  PubMed  CAS  Google Scholar 

  49. Vieillard-Baron A, Millington SJ, Sanfillipo F, Chew M, Diaz-Gomez J, McLean A, et al. A decade of progress in critical care echocardiography: a narrative review. Intensive Care Med. 2019;45(6):770–88.

    Article  PubMed  Google Scholar 

  50. Bilotta F, Dei Giudici L, Lam A, Rosa G. Ultrasound-based imaging in neurocritical care patients: a review of clinical applications. Neurol Res. 2013;35(2):149–58.

    Article  PubMed  Google Scholar 

  51. Volpicelli G, Elbarbary M, Blaivas M, Lichtenstein DA, Mathis G, Kirkpatrick AW, et al. International evidence-based recommendations for point-of-care lung ultrasound. Intensive Care Med. 2012;38(4):577–91.

    Article  PubMed  Google Scholar 

  52. Pivetta E, Goffi A, Lupia E, Tizzani M, Porrino G, Ferreri E, et al. Lung ultrasound-implemented diagnosis of acute decompensated heart failure in the ED: a SIMEU multicenter study. Chest. 2015;148(1):202–10.

    Article  PubMed  Google Scholar 

  53. Lichtenstein DA, Mezière GA. Relevance of lung ultrasound in the diagnosis of acute respiratory failure: the BLUE protocol. Chest. 2008;134(1):117–25.

    Article  PubMed  PubMed Central  Google Scholar 

  54. Volpicelli G, Mussa A, Garofalo G, Cardinale L, Casoli G, Perotto F, et al. Bedside lung ultrasound in the assessment of alveolar-interstitial syndrome. Am J Emerg Med. 2006;24(6):689–96.

    Article  PubMed  Google Scholar 

  55. Yousefifard M, Baikpour M, Ghelichkhani P, Asady H, Shahsavari Nia K, Moghadas Jafari A, et al. Screening performance characteristic of ultrasonography and radiography in detection of pleural effusion, a meta-analysis. Emerg (Tehran, Iran). 2016;4(1):1–10.

    Google Scholar 

  56. Reissig A, Copetti R, Mathis G, Mempel C, Schuler A, Zechner P, et al. Lung ultrasound in the diagnosis and follow-up of community-acquired pneumonia: a prospective, multicenter, diagnostic accuracy study. Chest. 2012;142(4):965–72.

    Article  PubMed  Google Scholar 

  57. Alrajab S, Youssef A, Akkus N, Caldito G. Pleural ultrasonography versus chest radiography for the diagnosis of pneumothorax: review of the literature and meta-analysis. Crit Care. 2013;17(5):R208.

    Article  PubMed  PubMed Central  Google Scholar 

  58. Pivetta E, Goffi A, Nazerian P, Castagno D, Tozzetti C, Tizzani P, et al. Lung ultrasound integrated with clinical assessment for the diagnosis of acute decompensated heart failure in the emergency department: a randomized controlled trial. Eur J Heart Fail. 2019;21(6):754–66.

    Article  PubMed  CAS  Google Scholar 

  59. Merenkov VV, Kovalev AN, Gorbunov VV. Bedside lung ultrasound: a case of neurogenic pulmonary edema. Neurocrit Care. 2013;18(3):391–4.

    Article  PubMed  Google Scholar 

  60. Williamson CA, Co I, Pandey AS, Gregory Thompson B, Rajajee V. Accuracy of daily lung ultrasound for the detection of pulmonary edema following subarachnoid hemorrhage. Neurocrit Care. 2016;24(2):189–96.

    Article  PubMed  Google Scholar 

  61. Bentzer P, Griesdale DE, Boyd J, MacLean K, Sirounis D, Ayas NT. Will this hemodynamically unstable patient respond to a bolus of intravenous fluids? JAMA. 2016;316(12):1298–309.

    Article  PubMed  Google Scholar 

  62. Vignon P, Repessé X, Begot E, Léger J, Jacob C, Bouferrache K, et al. Comparison of echocardiographic indices used to predict fluid responsiveness in ventilated patients. Am J Respir Crit Care Med. 2017;195(8):1022–32.

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Alberto Goffi .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2021 Springer Nature Switzerland AG

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Goffi, A., de Oliveira Manoel, A.L., Robba, C. (2021). Severe Respiratory Failure: ARDS and ECMO. In: Robba, C., Citerio, G. (eds) Echography and Doppler of the Brain. Springer, Cham. https://doi.org/10.1007/978-3-030-48202-2_14

Download citation

  • DOI: https://doi.org/10.1007/978-3-030-48202-2_14

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-48201-5

  • Online ISBN: 978-3-030-48202-2

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics