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Role of Flavonoids in Obesity Induced Cardiovascular Dysfunction

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Biochemistry of Cardiovascular Dysfunction in Obesity

Part of the book series: Advances in Biochemistry in Health and Disease ((ABHD,volume 20))

Abstract

Obesity is found to be a contributing risk factor for Cardiovascular Dysfunction (CVD), coronary heart disease (CHD) and heart failure (HF). Obesity is found to be linked to the release of several proinflammatory mediators. The fluctuation in the levels of these mediators and adipocytokines released by the adipocytes further leads to cardiovascular complications. The increase in the risk of CVD and mortality caused by obesity is due to increasing levels of atherosclerotic plaques in the arteries and blood vessels leading to the heart. The current available treatment strategies leads to several unwanted side effects for the patient which leads to a decreased quality of life. Flavonoids are polyphenolic compounds which occur naturally in nature. Several clinical and preclinical studies have demonstrated that flavonoids are beneficial in decreasing the cardiovascular risks presented by obesity. The mechanism of action primarily depends on the antioxidant and anti-inflammatory actions of flavonoids. In view of these observations, the intake of foods containing flavonoids have enormous potential in preventing obesity induced cardio-metabolic diseases. However, randomized and placebo-controlled clinical trials are needed to determine the long-term safety and efficacy of different flavonoids. The focus of this chapter is to highlight the cost-effective health benefits of flavonoid-rich-foods and dietary supplements containing flavonoids for the prevention and cure of obesity linked cardiovascular diseases (CVDs).

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Abbreviations

CVDs:

Cardiovascular diseases

CHD:

Congenital heart disease

LDL:

Low density lipoproteins

HDL:

High density lipoproteins

BMI:

Body mass index

TNF-α:

Tumor necrosis factor alpha

IL-1:

Interleukin-1

IL-6:

Interleukin-6

SAA:

Serum amyloid A

MI:

Myocardial infarction

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The authors declare no conflict of interest.

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Authors and Affiliations

  1. Shobhaben Pratapbhai Patel School of Pharmacy and Technology Management, SVKM’s NMIMS, Mumbai, 400056, Maharashtra, India

    Zoha Ahmed, Antara Pal, Siddhi Bagwe-Parab & Ginpreet Kaur

  2. Department of Pathology and Laboratory Medicine, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada

    Harpal Singh Buttar

  3. Department of Biotechnology, Maharishi Markandeshwar (Deemed to be University), Mullana, Ambala, Haryana, India

    Hardeep Singh Tuli

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  1. Zoha Ahmed
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  2. Antara Pal
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  3. Siddhi Bagwe-Parab
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  4. Ginpreet Kaur
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  5. Harpal Singh Buttar
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  6. Hardeep Singh Tuli
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Correspondence to Ginpreet Kaur .

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Editors and Affiliations

  1. Asper Clinical Research Institute, St. Boniface Hospital, Winnipeg, MB, Canada

    Paramjit S. Tappia

  2. Institute of Cardiovascular Sciences, St. Boniface Hospital, Winnipeg, MB, Canada

    Sukhwinder K. Bhullar

  3. Institute of Cardiovascular Sciences, St. Boniface Hospital, Winnipeg, MB, Canada

    Naranjan S. Dhalla

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Ahmed, Z., Pal, A., Bagwe-Parab, S., Kaur, G., Buttar, H.S., Tuli, H.S. (2020). Role of Flavonoids in Obesity Induced Cardiovascular Dysfunction. In: Tappia, P.S., Bhullar, S.K., Dhalla, N.S. (eds) Biochemistry of Cardiovascular Dysfunction in Obesity. Advances in Biochemistry in Health and Disease, vol 20. Springer, Cham. https://doi.org/10.1007/978-3-030-47336-5_16

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