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Role of Polycyclic Aromatic Hydrocarbons as EDCs in Metabolic Disorders

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Endocrine Disrupting Chemicals-induced Metabolic Disorders and Treatment Strategies

Abstract

Polycyclic aromatic hydrocarbons (PAHs) are universal toxic chemicals produced mainly due to improper combustion of organic substances like wood, coal, petrol, oil, etc. Release of these pollutants into the environment is because of various activities including open air burning, natural losses, leakage of various chemicals, accidental fire, and many more. The most common sources of PAH production are household heating systems, plants using coal for gasification and liquefaction, various industries and factories manufacturing different livelihood products, petroleum refineries, and automobile exhaust. In the environment, PAHs exist in gaseous-phase and sorbet to aerosols. The movement of PAH from atmosphere to humans is strongly dependent on its phase in the air and the route of entry to human body. Soil and water are the main sources of PAHs deposition in the ecosystem. Many PAHs act as endocrine-disrupting chemicals (EDCs) having a strong blow on the regulation of endocrine dependent functions including metabolism, growth, reproduction, immune system, and may also have toxic and carcinogenic properties. After exposure, PAHs enter into the human body through different routes, get absorbed, and metabolized via cytochrome P450 oxidation system. PAHs are obesogens causing dysregulation of hormonal network controlling appetite and endocrine tissues which changes insulin sensitivity and lipid metabolism. The time of obesogens exposure (prenatal, postnatal, early childhood, and young) possesses different consequences on the entire life span of an individual. Different assays are used to check PAHs both qualitatively and quantitatively in various samples.

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Authors and Affiliations

  1. College of Animal Science and Veterinary Medicine, Shanxi Agricultural University, Taigu, Shanxi, People’s Republic of China

    Ajab Khan, Anam Ahsan & Hongquan Li

  2. Department of Pharmaceutics, School of Pharmacy, China Pharmaceutical University, Nanjing, Jiangsu, People’s Republic of China

    Muhammad Asim Farooq

  3. Key Laboratory of Cardiovascular and Cerebrovascular Medicine, School of Pharmacy, Nanjing Medical University, Nanjing, Jiangsu, People’s Republic of China

    Muhammad Naveed

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  1. Ajab Khan
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  4. Muhammad Naveed
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  1. Department of Pharmaceutical Chemistry, Government College University Faisalabad, Faisalabad, Pakistan

    Muhammad Sajid Hamid Akash

  2. Department of Pharmacy, University of Agriculture Faisalabad, Faisalabad, Pakistan

    Kanwal Rehman

  3. Department of Chemistry, COMSATS University Islamabad, Islamabad, Pakistan

    Muhammad Zaffar Hashmi

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Khan, A., Ahsan, A., Farooq, M.A., Naveed, M., Li, H. (2021). Role of Polycyclic Aromatic Hydrocarbons as EDCs in Metabolic Disorders. In: Akash, M.S.H., Rehman, K., Hashmi, M.Z. (eds) Endocrine Disrupting Chemicals-induced Metabolic Disorders and Treatment Strategies. Emerging Contaminants and Associated Treatment Technologies. Springer, Cham. https://doi.org/10.1007/978-3-030-45923-9_19

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