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Senolysis and Senostasis Through the Plasma Membrane

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Senolytics in Disease, Ageing and Longevity

Part of the book series: Healthy Ageing and Longevity ((HAL,volume 11))

Abstract

With increasing evidence that senescent cells are detrimental towards a range of age-associated diseases and physiologic declines, there is rising urgency to develop interventions to suppress their adverse effects. Most senolytic approaches aim to eliminate senescent cells by rendering them vulnerable to apoptosis, while senostatic (senomorphic) approaches do not destroy the cell and instead suppress a specific senescent trait. In both senolysis and senostasis, the major goals include reducing the senescence-associated secretory phenotype (SASP) and to enhance the immunogenicity of the senescent compartment. These therapeutic aims are best elicited from the plasma membrane, although efforts to identify plasma membrane targets are only now beginning. We discuss several plasma membrane proteins expressed preferentially in senescent cells and their roles in neutralizing senescent cells by immune-mediated senolysis (as reported for DPP4, VIM, and NKFB2 ligands) and by suppressing the SASP (as reported for SCAMP4 and CD36). We identify the advantages and challenges of developing therapeutic approaches directed at the plasma membrane of senescent cells.

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Acknowledgements

This work was supported by the NIA IRP, NIH, and by the Chungnam National University research fund.

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Authors and Affiliations

  1. Laboratory of Genetics and Genomics, National Institute on Aging Intramural Research Program, National Institutes of Health, Baltimore, MD, 21224, USA

    Kyoung Mi Kim, Ji Heon Noh & Myriam Gorospe

  2. Department of Biochemistry, Chungnam National University, Daejeon, 34134, Republic of Korea

    Ji Heon Noh

  3. Department of Biological Sciences, Chungnam National University, Daejeon, 34134, Republic of Korea

    Kyoung Mi Kim

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Correspondence to Kyoung Mi Kim .

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Editors and Affiliations

  1. CRUK Cambridge Centre Early Detection Programme, Department of Oncology, Hutchison/MRC Research Centre, University of Cambridge, Cambridge, UK

    Daniel Muñoz-Espin

  2. European Research Institute for the Biology of Aging (ERIBA), University Medical Center Groningen, Groningen, The Netherlands

    Marco Demaria

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Kim, K.M., Noh, J.H., Gorospe, M. (2020). Senolysis and Senostasis Through the Plasma Membrane. In: Muñoz-Espin, D., Demaria, M. (eds) Senolytics in Disease, Ageing and Longevity. Healthy Ageing and Longevity, vol 11. Springer, Cham. https://doi.org/10.1007/978-3-030-44903-2_7

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