Abstract
During the last decade, positron emission tomography/computed tomography (PET/CT) and single-photon emission computed tomography/computed tomography (SPECT/CT) have procured advances in research and clinical application of fusion imaging. The recent introduction of digital PET/CT opens new horizons for multimodality molecular imaging. This system offers more precise, simultaneous morphologic, functional, and molecular information of a living system. Moreover, other combinations of anatomic and functional imaging modalities hold promise in basic medical research or in clinical medicine. These developments are paralleled by advances in the field of biomolecules and particles that will provide new agents useful for more than one imaging modality and will facilitate the study of the same target by different imaging devices. Digital PET/CT may emerge as a powerful multimodality technique with great clinical impact on the diagnosis and therapy assessment of oncological diseases due to its enhanced sensitivity.
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References
Anger HO (1957) Scintillation camera. Rev Sci Instrum 29:27–33
Acuff SN, Jackson AS, Subramaniam RM, Osborne D (2018) Practical considerations for integrating PET/CT into radiation therapy planning. J Nucl Med Technol 46(4):343–348
Bennett CF, Swayze EE (2010) RNA targeting therapeutics: molecular mechanisms of antisense oligonucleotides as a therapeutic platform. Annu Rev Pharmacol Toxicol 50:259–293
Bennett CF, Baker BF, Pham N et al (2017) Pharmacology of antisense drugs. Annu Rev Pharmacol Toxicol 57:81–105
Bergeret S, Charbit J, Ansquer C et al (2019) Novel PET tracers: added value for endocrine disorders. Endocrine 64(1):14–30
Beyer T, Townsend DW, Brun T et al (2000) A combined PET/CT scanner for clinical oncology. J Nucl Med 41:1369–1379
Bundschuh R, Martínez-Möller A, Essler M et al (2008) Local motion correction for lung tumours in PET/CT—First results. Eur J Nucl Med Mol Imaging 35:1981–1988
Catana C, Procissi D, Wu YB et al (2008) Simultaneous in vivo positron emission tomography and magnetic resonance imaging. Proc Natl Acad Sci USA 105:3705–3710
Carne R, O’Brien T, Kilpatrick C et al (2004) MRI-negative PET-positive temporal lobe epilepsy: a distinct surgically remediable syndrome. Brain 127:2276–2285
Chakrabarti A, Aruva MR, Sajankila SP (2005) Synthesis of novel peptide nucleic acid-peptide chimera for non-invasive imaging of cancer. Nucleosides Nucleotides Nucleic Acids 24:409–414
Chakrabarti A, Zhang K, Aruva MR et al (2007) Radiohybridization PET imaging of KRAS G12D mRNA expression in human pancreas cancer xenografts with [64Cu]DO3A-peptide nucleic acid-peptide nanoparticles. Cancer Biol Ther 6:948–956
Chang G, Chang T, Pan T, Clark JW Jr, Mawlawi OR (2010) Implementation of an automated respiratory amplitude gating technique for PET/CT: clinical evaluation. J Nucl Med 51:16–24
Chandra PS, Salamon N, Huang J et al (2006) FDG-PET/MRI Coregistration and diffusion-tensor imaging distinguish epileptogenic tubers and cortex in patients with tuberous sclerosis complex: a preliminary report. Epilepsia 47:1543–1549
Cheng NM, Yu CT, Ho KC, Wu YC, Liu YC, Wang CW, Yen TC (2009) Respiration-averaged CT for attenuation correction in non-small-cell lung cancer. Eur J Nucl Med Mol Imaging 36:607–615
Cherry SR, Louie AY, Jacobs RE (2008) The integration of positron emission tomography with magnetic resonance imaging. Proc IEEE 96:416–438
Cherry SR, Jones T, Karp JS et al (2018) Totalbody PET: maximizing sensitivity to create new opportunities for clinical research and patient care. J Nucl Med 59:3–12
Degenhardt C, Prescher G, Frach T et al (2009) The digital silicon photomultiplier: a novel sensor for the detection of scintillation light. In: IEEE Nuclear Science Conference Record 2383–2386
Dimitrakopoulou-Strauss A (2015) PET-based molecular imaging in personalized oncology: potential of the assessment of therapeutic outcome. Future Oncol 11(7):1083–1091
Ehman E, Johnson G, Villanueva-Meyer J et al (2017) PET/MRI: where might it replace PET/CT? J Magn Reson Imaging 46(5):1247–1262
Faria SL, Menard S, Devic S, Sirois C, Souhami L, Lisbona R, Freeman CR (2008) Impact of FDG- PET/CT on radiotherapy volume delineation in non-small-cell lung cancer and correlation of imaging stage with pathologic findings. Int J Radiat Oncol Biol Phys 70:1035–1038
Flavell R, Naeger D, Aparici C et al (2016) Malignancies with low fluorodeoxyglucose uptake at PET/CT: pitfalls and prognostic importance: resident and fellow education feature. RadioGraphics 36:293–294
Frach T, Prescher G, Degenhardt C et al (2009) The digital silicon photomultiplier: principle of operation and intrinsic detector performance. In: IEEE Nuclear Science Conference Record 1959–1965
Fuentes-Ocampo F, López-Mora DA, Flotats A et al (2019) Digital versus analog PET/CT: intra-subject comparison of the SUVmax in target lesions and reference regions. Eur J Nucl Med Mol Imaging. In press
Germano PM, Le SV, Oh DS et al (2004) Differential coupling of PAC1 SV1 splice variant of human colonic tumors to the activation of intracellular cAMP but not intracellular Ca2+ does not activate tumor proliferation. J Mol Neurosci 22:83–92
Goerres GW, Stupp R, Barghouth G et al (2005) The value of PET, CT and in-line PET/CT in patients with gastrointestinal stromal tumours: long-term outcome of treatment with imatinib mesylate. Eur J Nucl Med Mol Imaging 32:153–162
Guerra L, Ponti E, Morzenti S et al (2017) Respiratory motion management in PET/CT: applications and clinical usefulness. Curr Radiopharm 10(2):85–92
Guido A, Fuccio L, Rombi B, Castellucci P, Cecconi A, Bunkheila F, Fuccio C, Spezi E, Angelini AL, Barbieri E (2009) Combined 18F-FDG-PET/CT imaging in radiotherapy target delineation for head-and-neck cancer. Int J Radiat Oncol Biol Phys 73:759–763
Hersey P, Bastholt L, Chiarion-Sileni V, Cinat G, Dummer R, Eggermont AM, Espinosa E, Hauschild A, Quirt I, Robert C, Schadendorf D (2009) Small molecules and targeted therapies in distant metastatic disease. Ann Oncol 20(Suppl6):vi35–vi40
Heusch P, Buchbender C, Kohler J et al (2013) Correlation of the apparent diffusion coefficient (ADC) with the standardized uptake value (SUV) in hybrid 18F-FDG PET/MRI in non-small cell lung cancer (NSCLC) lesions: initial results RoFo 185:1056–1062
Hofmann M, Steinke F, Scheel V et al (2008) MRI-based attenuation correction for PET/MRI: a novel approach combining pattern recognition and atlas registration. J Nucl Med 49:1875–1883
Hutton BF (2014) The origin of SPECT and SPECT/CT. Eur J Nucl Med Mol Imaging 41(Suppl 1):S3–S16
Inobushi M, Tatsumi M, Yamamoto Y et al (2018) European research trends in nuclear medicine. Ann Nucl Med 32:579–582
Judenhofer MS, Wehrl HF, Newport DF et al (2008) Simultaneous PET-MRI: a new approach for functional and morphological imaging. Nat Med 14:459–465
Kang B, Lee JM, Song YS et al (2016) Added value of integrated whole-body PET/MRI for evaluation of colorectal cancer: comparison with contrast-enhanced MDCT. AJR Am J Roentgenol 206:W10–W20
Koopman D, Groot Koerkamp M, Jager PL et al (2017) Digital PET compliance to EARL accreditation specifications. EJNMMI Phys 4:9. https://doi.org/10.1186/s40658-017-0176-5
Kuker R, Sztejnberg M, Gulec S (2017) I-124 imaging and dosimetry. Mol Imaging Radionucl Ther 26(suppl 1):66–73
Kumar P, Tripathi SK, Chen CP et al (2019) Evaluating Ga-68 peptide conjugates for targeting VPAC receptors: stability and pharmacokinetics. Mol Imaging Biol 21(1):130–139
Lendvai G, Estrada S, Bergström M (2009) Radiolabelled oligonucleotides for imaging of gene expression with PET. Curr Med Chem 16:4445–4461
Ljungberg M, Preterius H (2018) SPET/CT: an update on technological developments and clinical applications. Br J Radiol 90:20160402
Lopez-Mora DA, Flotats A, Fuentes-Ocampo F et al (2019) Comparison of image quality and lesion detection between digital and analog PET/CT. Eur J Nucl Med Mol Imaging 46(6):1383–1390
Mehranian A, Arabi H, Zaidi H (2016) Vision 20/20: magnetic resonance imaging-guided attenuation correction in PET/MRI: challenges, solutions, and opportunities. Med Phys 43(3):1130–1155. https://doi.org/10.1118/1.4941014
Messerli M, Stolzmann P, Egger-Sigg M et al (2018) Impact of a Bayesian penalized likelihood reconstruction algorithm on image quality in novel digital PET/CT: clinical implications for the assessment of lung tumors. EJNMMI Phys 5:27. https://doi.org/10.1186/s40658-018-0223-x
Mittra E, Quon A (2009) Positron emission tomography/computed tomography: the current technology and applications. Radiol Clin N Am 47:147–160
Mollet P, Keereman Vincent, Bini J et al (2014) Improvement of attenuation correction in time-of-flight PET/MR imaging with a positron-emitting source. J Nucl Med 55(2):329–336
Nguyen N, Vercher-Conejero JL, Sattar A et al (2015) Image quality and diagnostic performance of a digital PET prototype in patients with oncologic diseases: initial experience and comparison with analog PET. J Nucl Med 56:1378–1385
Patton JA, Townsend DW, Hutton BF (2009) Hybrid imaging technology: from dreams and vision to clinical devices. Semin Nucl Med 39:247–263
Rausch I, Ruiz A, Valverde-Pascual I et al (2018) Performance evaluation of the Philips Vereos PET/CT system according to the NEMA NU2-2012 standard. J Nucl Med 60(4):561–567
Raylman RR, Majewski S, Lemieux SK et al (2006) Simultaneous MRI and PET imaging of a rat brain. Phys Med Biol 51:6371–6379
Ruhlmann V, Ruhlmann M, Bellendorf A et al (2016) Hybrid imaging for detection of carcinoma of unknown primary: a preliminary comparison trial of whole-body PET/MRI versus PET/CT. Eur J Radiol 85:1941–1947
Salamon N, Kung J, Shaw S et al (2008) FDG-PET/MRI coregistration improves detection of cortical dysplasia in patients with epilepsy. Neurology 71:1594–1601
Santhanam P, Taieb D, Solnes L et al (2017) Utility of I-124 PET/CT in identifying radioiodine avid lesions in differentiated thyroid cancer: a systematic review and meta-analysis. Clin Endocrinol (Oxf) 86(5):645–651
Sawicki LM, Grueneisen J, Buchbender C et al (2016) Evaluation of the outcome of lung nodules missed on 18F-FDG PET/MRI compared with 18F-FDG PET/CT in patients with known malignancies. J Nucl Med 57:15–20
Sawicki LM, Grueneisen J, Buchbender C et al (2016) Comparative performance of 18F-FDG PET/MRI and 18F-FDG PET/CT in detection and characterization of pulmonary lesions in 121 oncologic patients. J Nucl Med 57:582–586
Schelhaas S, Heinzmann K, Bollineni VR (2017) Preclinical applications of 3′-deoxy-3′-[18F]fluoro-thymidine in oncology-A systematic review. Theranostics 7(1):40–50
Schillaci O, Urbano N (2019) Digital PET/CT: a new intriguing chance for clinical nuclear medicine and personalized molecular imaging. Eur J Nucl Med Mol Imaging 46(6):1222–1225
Schlemmer HPW, Pichler BJ, Schmand M et al (2008) Simultaneous MR/PET imaging of the human brain: feasibility study. Radiology 248:1028–1035
Schmidt H, Brendle C, Schraml C et al (2013) Correlation of simultaneously acquired diffusion-weighted imaging and 2-deoxy-[18F] fluoro-2-D-glucose positron emission tomography of pulmonary lesions in a dedicated whole-body magnetic resonance/positron emission tomography system. Invest Radiol 48:247–255
Schulz S, Rocken C, Mawrin C et al (2004) Immunocytochemical identification of VPAC1, VPAC2 and PAC1 receptors in normal and neoplastic human tissues with subtype specific antibodies. Clin Cancer Res 10:8234–8242
Sekine T, Delso G, Zeimpekis KG et al (2018) Reduction of (18)F-FDG dose in clinical PET/MR imaging by using silicon photomultiplier detectors. Radiology 286:249–259
Shah C, Miller TW, Wyatt SK, McKinley ET, Olivares MG, Sanchez V, Nolting DD, Buck JR, Zhao P, Ansari MS, Baldwin RM, Gore JC, Schiff R, Arteaga CL, Manning HC (2009) Imaging biomarkers predict response to anti-HER2 (ErbB2) therapy in preclinical models of breast cancer. Clin Cancer Res 15:4712–4721
Sikkandhar M, Krishna KG, Sachin M et al (2017) PET/MRI: a frontier in era of complementary hybrid imaging. Eur J Hybrid Imaging 2018; 2(1):12
Slomka PJ, Pan T, Germano G (2016) Recent advances and future progress in PET instrumentation. Semin Nucl Med 46(1):5–19
Smith CP, Laucis A, Harmon S et al (2019) Novel imaging in detection of metastatic prostate cancer. Curr Oncol Rep 21(4):31
Specht L, Berthelsen AK (2018) PET/CT in radiation therapy planning. Semin Nucl Med 48(1):67–75
Stieb S, Eleftheriou A, Warnock G et al (2018) Longitudinal PET imaging for tumor hypoxia during the courseof radiotherapy. Eur J Nucl Med Mol Imaging 45(12):2201–2217
Tan PH, Bay BH, Yip G et al (2005) Immunohistochemical detection of Ki67 in breast cancer correlates with transcriptional regulation of genes related to apoptosis and cell death. Mod Pathol 18:374–381
Tang C, Nie D, Tang G et al (2017) Radiosyntesis and biological evaluation of N-(2-[18F]fluoropropionyl)-3,4-dihydroxy-l-phenylalanine as a PET tracer for oncologic imaging. Nucl Med Biol 50:39–46
Tian X, Aruva MR, Qin W et al (2004) External imaging of CCND1 cancer gene activity in experimental human breast cancer xenografts with 99mTc-peptide–peptide nucleic acid- peptide chimeras. J Nucl Med 45:2070–2082
Tian X, Aruva MR, Wolfe HR et al (2005) Tumor-targeting peptide-PNA peptide chimeras for imaging overexpressed oncogene mRNAs. Nucleosides Nucleotides Nucleic Acids 24:1085–1091
Tian X, Aruva MR, Zhang K et al (2007) PET imaging of CCND1 mRNA in human MCF7 estrogen receptor positive breast cancer xenografts with oncogene-specific [64Cu] chelator- peptide nucleic acid-IGF1 analog radiohybridization probes. J Nucl Med 48:1699–1707
Townsend DW (2008) Multimodality imaging of structure and function. Phys Med Biol 53:R1–R39
Velikyan I (2014) Prospective of 68 Ga-radiopharmaceutical development. Theranostics 4(1):47–80
Voigt W (2017) Advanced PET imaging in oncology: status and developments with current and future relevance to lung cancer care. Curr Opin Oncol 30(2):77–83
Woody C, Schlyer D, Vaska P et al (2007) Preliminary studies of a simultaneous PET/MRI scanner based on the RatCAP small animal tomograph. Nucl Instrum Methods A 571:102–105
Wright C, Binzel K, Zhang J et al (2017) Advanced functional tumor imaging and precision nuclear medicine enabled by digital PET technologies. Contrast Media Mol I. https://doi.org/10.1155/2017/5260305
Zaidi H (2007) Is MR-guided attenuation correction a viable option for dual modality PET/MR imaging? Radiology 244:639–642
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López-Mora, D.A., Lagos, L.A., Estorch, M., Carrio, I. (2020). Future Challenges of Multimodality Imaging. In: Schober, O., Kiessling, F., Debus, J. (eds) Molecular Imaging in Oncology. Recent Results in Cancer Research, vol 216. Springer, Cham. https://doi.org/10.1007/978-3-030-42618-7_30
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