Abstract
Bacterial infections are a major threat for the global population. Realizing the interaction between the infectious bacteria and antibacterial agents is fundamental to understand the novel therapeutic approaches that combat the bacterial infection leading to morbidity and mortality. At present situation, contemporary healthcare sectors and clinical microbiology deal with the current issue, discovering novel therapeutic strategies to overcome bacterial infections associated with rapidly accelerating multidrug-resistant bacteria. Currently, a remarkable advancement has been occurred in nanobiotechnology toward the formulation of several novel nanoparticles (NPs) that are actively participated as potential antibacterial agents. The control over morphologies and several significant features including size, shape, and nature of the particles made it an extensive area of research in NP synthesis. This feasibility in the technology for the development of NPs facilitates utilization of NPs in the wide range of applications including biomedicine, biosensor, and catalyst with cost-effective manner. The NP-based antibacterial agents are out grouped from the fundamental antibacterial agents such as antibiotic and anti-infective. Nanoantibacterial agents are able to address the regular complication in mechanism of antibiotic resistance including multidrug efflux pumps, permeability regulation, degradation of antibacterial agents, and untargeted site binding affinity mutations. This highly spotted nanoantimicrobial agents are developed by means of different methodologies for both research and commercial utilization. These methodologies are widely classified into physical, chemical, and biological, which are gaining significant advancements in the recent years. The present chapter critically discusses the recent development in the nanobiotechnology, availability of various methods for the synthesis of NPs, field-specific formulation of NPs, wide range of application of NPs in the healthcare sectors specifically antibacterial and biofilm, and future perspective in the field of nanobiotechnology.
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Paramanantham, P., Siddhardha, B. (2020). Recent Advancements in the Design and Synthesis of Antibacterial and Biofilm Nanoplatforms. In: Prasad, R., Siddhardha, B., Dyavaiah, M. (eds) Nanostructures for Antimicrobial and Antibiofilm Applications. Nanotechnology in the Life Sciences. Springer, Cham. https://doi.org/10.1007/978-3-030-40337-9_14
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