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A Mechanostatistical Approach to Multiscale Computational Bone Remodelling

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The Computational Mechanics of Bone Tissue

Part of the book series: Lecture Notes in Computational Vision and Biomechanics ((LNCVB,volume 35))

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Abstract

Computational models in biomechanics are generally unable to incorporate mechanical and anatomical data over the entire range of relevant spatial scales. This chapter proposes the construction of a framework, which unites several methodologies that operate on traditionally different aspects of bone remodelling, bridging the gap between previously incompatible data. The presented framework is used to solve the load adaptation response of the femoral neck as an application and consists of passing data from different sources across a multitude of spatial scales to solve for both organ-level and Haversian-level biomechanical states. The solutions are then stored in a database, to be utilised by a statistical method which can quickly estimate new load adaptation responses for which solutions were not previously generated, cutting down computation time.

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Author information

Authors and Affiliations

  1. Auckland Bioengineering Institute, 70 Symonds St, Auckland, New Zealand

    X. Wang

  2. Department of Engineering Science, Auckland Bioengineering Institute, 70 Symonds St, Auckland, New Zealand

    J. Fernandez

Authors
  1. X. Wang
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  2. J. Fernandez
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Corresponding author

Correspondence to X. Wang .

Editor information

Editors and Affiliations

  1. Department of Mechanical Engineering, School of Engineering, Polytechnic of Porto (ISEP), Porto, Portugal

    Jorge Belinha

  2. Departament de Patologia i Terapèutica Experimental, University of Barcelona, Barcelona, Spain

    Maria-Cristina Manzanares-Céspedes

  3. Department of Mechanical Engineering, University of Aveiro, Aveiro, Portugal

    António M. G. Completo

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Wang, X., Fernandez, J. (2020). A Mechanostatistical Approach to Multiscale Computational Bone Remodelling. In: Belinha, J., Manzanares-Céspedes, MC., Completo, A. (eds) The Computational Mechanics of Bone Tissue. Lecture Notes in Computational Vision and Biomechanics, vol 35. Springer, Cham. https://doi.org/10.1007/978-3-030-37541-6_6

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