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Characteristics of Visual Electrophysiology in Inflammatory Disorders

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Handbook of Clinical Electrophysiology of Vision

Abstract

This chapter summarizes the application of electroretinogram, electrooculogram, and/or visual evoked potential in patients with acute zonal occult outer retinopathy, multiple evanescent white dot syndrome, acute posterior multifocal placoid pigment epitheliopathy, birdshot chorioretinopathy, autoimmune retinopathy, and neuroretinopathy.

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References

  1. Gass JD. Acute zonal occult outer retinopathy. Donders Lecture: The Netherlands Ophthalmological Society, Maastricht, Holland, June 19, 1992. J Clin Neuroophthalmol. 1993;13(2):79–97.

    CAS  PubMed  Google Scholar 

  2. Boudreault KA, et al. Quantitative autofluorescence intensities in acute zonal occult outer retinopathy vs healthy eyes. JAMA Ophthalmol. 2017;135(12):1330–8.

    Article  PubMed  PubMed Central  Google Scholar 

  3. Wang Q, et al. Fundus autofluorescence imaging in the assessment of acute zonal occult outer retinopathy. Ophthalmologica. 2017;237(3):153–8.

    Article  PubMed  Google Scholar 

  4. Mrejen S, et al. Acute zonal occult outer retinopathy: a classification based on multimodal imaging. JAMA Ophthalmol. 2014;132(9):1089–98.

    Article  PubMed  Google Scholar 

  5. Fujiwara T, et al. Fundus autofluorescence and optical coherence tomographic findings in acute zonal occult outer retinopathy. Retina. 2010;30(8):1206–16.

    Article  PubMed  Google Scholar 

  6. Takai Y, et al. Morphological study of acute zonal occult outer retinopathy (AZOOR) by multiplanar optical coherence tomography. Acta Ophthalmol. 2009;87(4):408–18.

    Article  PubMed  Google Scholar 

  7. Jacobson SG, et al. Pattern of retinal dysfunction in acute zonal occult outer retinopathy. Ophthalmology. 1995;102(8):1187–98.

    Article  CAS  PubMed  Google Scholar 

  8. Francis PJ, et al. Acute zonal occult outer retinopathy: towards a set of diagnostic criteria. Br J Ophthalmol. 2005;89(1):70–3.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Li D, Kishi S. Loss of photoreceptor outer segment in acute zonal occult outer retinopathy. Arch Ophthalmol. 2007;125(9):1194–200.

    Article  PubMed  Google Scholar 

  10. Mkrtchyan M, et al. Outer retinal structure in patients with acute zonal occult outer retinopathy. Am J Ophthalmol. 2012;153(4):757–68, 768 e1.

    Article  PubMed  Google Scholar 

  11. Nakao S, et al. Spontaneous remission of acute zonal occult outer retinopathy: follow-up using adaptive optics scanning laser ophthalmoscopy. Graefes Arch Clin Exp Ophthalmol. 2015;253(6):839–43.

    Article  PubMed  Google Scholar 

  12. Makino S, Tampo H. Changes in optical coherence tomography findings in acute zonal occult outer retinopathy. Case Rep Ophthalmol. 2013;4(3):99–104.

    Article  PubMed  PubMed Central  Google Scholar 

  13. Tagami M, et al. Autologous antibodies to outer retina in acute zonal occult outer retinopathy. Jpn J Ophthalmol. 2014;58(6):462–72.

    Article  CAS  PubMed  Google Scholar 

  14. Jampol LM, Wiredu A. MEWDS, MFC, PIC, AMN, AIBSE, and AZOOR: one disease or many? Retina. 1995;15(5):373–8.

    Article  CAS  PubMed  Google Scholar 

  15. Gass JD. The acute zonal outer retinopathies. Am J Ophthalmol. 2000;130(5):655–7.

    Article  CAS  PubMed  Google Scholar 

  16. Gass JD. Are acute zonal occult outer retinopathy and the white spot syndromes (AZOOR complex) specific autoimmune diseases? Am J Ophthalmol. 2003;135(3):380–1.

    Article  PubMed  Google Scholar 

  17. Heckenlively JR, Ferreyra HA. Autoimmune retinopathy: a review and summary. Semin Immunopathol. 2008;30(2):127–34.

    Article  PubMed  Google Scholar 

  18. He SX, et al. Auto antibodies against retinal pigment epithelium in patients with atypical retinopathies. Invest Ophthalmol Vis Sci. 2010;51(5):E-Abstract 3771.

    Google Scholar 

  19. Qian CX, et al. Prevalence of Antiretinal antibodies in acute zonal occult outer retinopathy: a comprehensive review of 25 cases. Am J Ophthalmol. 2017;176:210–8.

    Article  PubMed  Google Scholar 

  20. Gass JD, Agarwal A, Scott IU. Acute zonal occult outer retinopathy: a long-term follow-up study. Am J Ophthalmol. 2002;134(3):329–39.

    Article  PubMed  Google Scholar 

  21. Abo-Shasha R, et al. Is acute zonal occult outer retinopathy an autoimmune condition? A case report and literature review. Ophthalmic Surg Lasers Imaging Retina. 2015;46(6):662–5.

    Article  PubMed  Google Scholar 

  22. Priem HA, et al. Electrophysiologic studies in birdshot chorioretinopathy. Am J Ophthalmol. 1988;106:430–6.

    Article  CAS  PubMed  Google Scholar 

  23. Hirose T, et al. Retinal function in birdshot retinochoroidopathy. Acta Ophthalmol. 1991;69:327–37.

    Article  CAS  Google Scholar 

  24. Menezo V, Taylor SR. Birdshot uveitis: current and emerging treatment options. Clin Ophthalmol. 2014;8:73–81.

    PubMed  Google Scholar 

  25. Holak HM, Szymaniec S, Holak SA. The pathogenesis of birdshot chorioretinopathy. Surv Ophthalmol. 2006;51(4):446–7; author reply 447.

    Article  PubMed  Google Scholar 

  26. Lei B, et al. Human melanoma-associated retinopathy (MAR) antibodies alter the retinal ON-response of the monkey ERG in vivo. Invest Ophthalmol Vis Sci. 2000;41:262–6.

    CAS  PubMed  Google Scholar 

  27. Shiraga S, Adamus G. Mechanism of CAR syndrome: anti-recoverin antibodies are the inducers of retinal cell apoptotic death via the caspase 9- and caspase 3-dependent pathway. J Neuroimmunol. 2002;132(1–2):72–82.

    Article  CAS  PubMed  Google Scholar 

  28. Chan JW. Paraneoplastic retinopathies and optic neuropathies. Surv Ophthalmol. 2003;48(1):12–38.

    Article  PubMed  Google Scholar 

  29. Adamus G, Ren G, Weleber RG. Autoantibodies against retinal proteins in paraneoplastic and autoimmune retinopathy. BMC Ophthalmol. 2004;4:5.

    Article  PubMed  PubMed Central  Google Scholar 

  30. Lu Y, et al. Melanoma-associated retinopathy: a paraneoplastic autoimmune complication. Arch Ophthalmol. 2009;127(12):1572–80.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  31. Iannaccone A, et al. Basal cell carcinoma-associated retinopathy and optic neuropathy (BARN): a novel paraneoplastic entity. Invest Ophthalmol Vis Sci. 2019;60(5):E-Abstract 2780.

    Google Scholar 

  32. Barnes AC, et al. Treatment of acute zonal occult outer retinopathy with intravitreal steroids. Ophthalmic Surg Lasers Imaging Retina. 2018;49(7):504–9.

    Article  PubMed  Google Scholar 

  33. Kuo YC, Chen N, Tsai RK. Acute Zonal Occult Outer Retinopathy (AZOOR): a case report of vision improvement after intravitreal injection of Ozurdex. BMC Ophthalmol. 2017;17(1):236.

    Article  PubMed  PubMed Central  Google Scholar 

  34. Chen SN, Yang CH, Yang CM. Systemic corticosteroids therapy in the management of acute zonal occult outer retinopathy. J Ophthalmol. 2015;2015:793026.

    PubMed  PubMed Central  Google Scholar 

  35. Jampol LM, et al. Multiple evanescent white dot syndrome. I. Clinical findings. Arch Ophthalmol. 1984;102(5):671–4.

    Article  CAS  PubMed  Google Scholar 

  36. Raven ML, et al. Multi-modal imaging and anatomic classification of the white dot syndromes. Int J Retina Vitreous. 2017;3:12.

    Article  PubMed  PubMed Central  Google Scholar 

  37. dell'Omo R, Pavesio CE. Multiple evanescent white dot syndrome (MEWDS). Int Ophthalmol Clin. 2012;52(4):221–8.

    Article  PubMed  Google Scholar 

  38. Ryan PT. Multiple evanescent white dot syndrome: a review and case report. Clin Exp Optom. 2010;93(5):324–9.

    Article  PubMed  Google Scholar 

  39. Matsumoto Y, Haen SP, Spaide RF. The white dot syndromes. Compr Ophthalmol Updat. 2007;8(4):179–200; discussion 203–4.

    Google Scholar 

  40. Quillen DA, et al. The white dot syndromes. Am J Ophthalmol. 2004;137(3):538–50.

    Article  PubMed  Google Scholar 

  41. Feigl B, Haas A, El-Shabrawi Y. Multifocal ERG in multiple evanescent white dot syndrome. Graefes Arch Clin Exp Ophthalmol. 2002;240(8):615–21.

    Article  PubMed  Google Scholar 

  42. Chen D, Martidis A, Baumal CR. Transient multifocal electroretinogram dysfunction in multiple evanescent white dot syndrome. Ophthalmic Surg Lasers. 2002;33(3):246–9.

    Article  CAS  PubMed  Google Scholar 

  43. Cheng JY, et al. The outer and inner retinal function in patients with multiple evanescent white dot syndrome. Clin Exp Ophthalmol. 2009;37(5):478–84.

    Article  PubMed  Google Scholar 

  44. Yamamoto S, et al. S-cone electroretinograms in multiple evanescent white dot syndrome. Doc Ophthalmol. 2003;106(2):117–20.

    Article  PubMed  Google Scholar 

  45. Gass JD. Acute posterior multifocal placoid pigment epitheliopathy. Arch Ophthalmol. 1968;80(2):177–85.

    Article  CAS  PubMed  Google Scholar 

  46. Roberts TV, Mitchell P. Acute posterior multifocal placoid pigment epitheliopathy: a long-term study. Aust N Z J Ophthalmol. 1997;25(4):277–81.

    Article  CAS  PubMed  Google Scholar 

  47. Vianna R, et al. Natural history and visual outcome in patients with APMPPE. Bull Soc Belge Ophtalmol. 1993;248:73–6.

    CAS  PubMed  Google Scholar 

  48. de Laey JJ. [Placoid epitheliopathy and serpiginous choroidopathy]. Bull Soc Belge Ophtalmol. 1989;230:105–22.

    Google Scholar 

  49. Xerri O, et al. Untreated acute posterior multifocal placoid pigment epitheliopathy (APMPPE): a case series. BMC Ophthalmol. 2018;18(1):76.

    Article  PubMed  PubMed Central  Google Scholar 

  50. Brydak-Godowska J, et al. Ocular complications in influenza virus infection. Ocul Immunol Inflamm. 2019;27(4):545–50.

    Article  PubMed  Google Scholar 

  51. Mangeon M, et al. Multimodal evaluation of patients with acute posterior multifocal placoid pigment epitheliopathy and serpiginous choroiditis. Ocul Immunol Inflamm. 2018;26(8):1212–8.

    Article  PubMed  Google Scholar 

  52. Goen TM, Terry JE. Acute posterior multifocal placoid pigment epitheliopathy. J Am Optom Assoc. 1987;58(2):112–7.

    CAS  PubMed  Google Scholar 

  53. Cozubas R, et al. Similarities and differences between three different types of white dot syndrome and the therapeutic possibilities. Rom J Ophthalmol. 2018;62(3):183–7.

    Article  PubMed  PubMed Central  Google Scholar 

  54. Thomson SP, Roxburgh ST. Acute posterior multifocal placoid pigment epitheliopathy associated with adenovirus infection. Eye (Lond). 2003;17(4):542–4.

    Article  CAS  Google Scholar 

  55. Azar P Jr, et al. Acute posterior multifocal placoid pigment epitheliopathy associated with an adenovirus type 5 infection. Am J Ophthalmol. 1975;80(6):1003–5.

    Article  PubMed  Google Scholar 

  56. Daniele S, et al. Progression of choroidal atrophy in acute posterior multifocal placoid pigment epitheliopathy. Ophthalmologica. 1998;212(1):66–72.

    Article  CAS  PubMed  Google Scholar 

  57. Aoyagi R, et al. Multifocal electroretinographic evaluation of macular function in acute posterior multifocal placoid pigment epitheliopathy. Doc Ophthalmol. 2013;126(3):253–8.

    Article  PubMed  Google Scholar 

  58. Leung E, et al. Birdshot retinochoroidopathy. In: Karth PA, O’Keefe GD, editors. eyewiki.aao.org. American Academy of Ophthalmology; 2019.

  59. Franceschetti A, Babel J. La chorioretinite en taches de bougie, manifestation de la maladie de Besnier-Boeck. Ophthalmologica. 1949;118(4–5):701–10.

    Article  CAS  PubMed  Google Scholar 

  60. Gasch AT, Smith JA, Whitcup SM. Birdshot retinochoroidopathy. Br J Ophthalmol. 1999;83(2):241–9.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  61. Rothova A, et al. Birdshot chorioretinopathy: long-term manifestations and visual prognosis. Ophthalmology. 2004;111(5):954–9.

    Article  PubMed  Google Scholar 

  62. Kiss S, et al. Long-term follow-up of patients with birdshot retinochoroidopathy treated with corticosteroid-sparing systemic immunomodulatory therapy. Ophthalmology. 2005;112(6):1066–71.

    Article  PubMed  Google Scholar 

  63. Levinson RD, et al. Research criteria for the diagnosis of birdshot chorioretinopathy: results of an international consensus conference. Am J Ophthalmol. 2006;141(1):185–7.

    Article  PubMed  Google Scholar 

  64. Thorne JE, et al. Loss of visual field among patients with birdshot chorioretinopathy. Am J Ophthalmol. 2008;145(1):23–8.

    Article  PubMed  Google Scholar 

  65. Leclercq M, et al. Tocilizumab for the treatment of birdshot uveitis that failed interferon alpha and anti-tumor necrosis factor-alpha therapy: two cases report and literature review. Clin Rheumatol. 2018;37(3):849–53.

    Article  PubMed  Google Scholar 

  66. Steeples LR, et al. Adalimumab in refractory cystoid macular edema associated with birdshot chorioretinopathy. Int Ophthalmol. 2018;38(3):1357–62.

    Article  PubMed  Google Scholar 

  67. Lopalco G, et al. IL-6 blockade in the management of non-infectious uveitis. Clin Rheumatol. 2017;36(7):1459–69.

    Article  PubMed  Google Scholar 

  68. Mesquida M, et al. Twenty-four month follow-up of tocilizumab therapy for refractory uveitis-related macular edema. Retina. 2018;38(7):1361–70.

    Article  CAS  PubMed  Google Scholar 

  69. Calvo-Rio V, et al. Efficacy of anti-IL6-receptor tocilizumab in refractory cystoid macular edema of birdshot retinochoroidopathy report of two cases and literature review. Ocul Immunol Inflamm. 2017;25(5):604–9.

    Article  PubMed  CAS  Google Scholar 

  70. Papo M, et al. Tocilizumab in severe and refractory non-infectious uveitis. Clin Exp Rheumatol. 2014;32(4 Suppl 84):S75–9.

    PubMed  Google Scholar 

  71. Mesquida M, et al. Long-term effects of tocilizumab therapy for refractory uveitis-related macular edema. Ophthalmology. 2014;121(12):2380–6.

    Article  PubMed  Google Scholar 

  72. Adan A, et al. Tocilizumab treatment for refractory uveitis-related cystoid macular edema. Graefes Arch Clin Exp Ophthalmol. 2013;251(11):2627–32.

    Article  CAS  PubMed  Google Scholar 

  73. Artornsombudh P, et al. Infliximab treatment of patients with birdshot retinochoroidopathy. Ophthalmology. 2013;120(3):588–92.

    Article  PubMed  Google Scholar 

  74. Sobrin L, et al. Daclizumab for treatment of birdshot chorioretinopathy. Arch Ophthalmol. 2008;126(2):186–91.

    Article  CAS  PubMed  Google Scholar 

  75. Magrys A, et al. The role of anti-alpha-enolase autoantibodies in pathogenicity of autoimmune-mediated retinopathy. J Clin Immunol. 2007;27(2):181–92.

    Article  CAS  PubMed  Google Scholar 

  76. Weleber RG, et al. Clinical and electrophysiologic characterization of paraneoplastic and autoimmune retinopathies associated with antienolase antibodies. Am J Ophthalmol. 2005;139(5):780–94.

    Article  CAS  PubMed  Google Scholar 

  77. Ren G, Adamus G. Cellular targets of anti-alpha-enolase autoantibodies of patients with autoimmune retinopathy. J Autoimmun. 2004;23(2):161–7.

    Article  CAS  PubMed  Google Scholar 

  78. Adamus G. Autoantibody-induced apoptosis as a possible mechanism of autoimmune retinopathy. Autoimmun Rev. 2003;2(2):63–8.

    Article  CAS  PubMed  Google Scholar 

  79. Adamus G. Antirecoverin antibodies and autoimmune retinopathy. Arch Ophthalmol. 2000;118(11):1577–8.

    Article  CAS  PubMed  Google Scholar 

  80. Mizener JB, et al. Autoimmune retinopathy in the absence of cancer. Am J Ophthalmol. 1997;123(5):607–18.

    Article  CAS  PubMed  Google Scholar 

  81. Heckenlively JR, et al. Autoimmune retinopathy: patients with antirecoverin immunoreactivity and panretinal degeneration. Arch Ophthalmol. 2000;118(11):1525–33.

    Article  CAS  PubMed  Google Scholar 

  82. Adamus G, Karren L. Autoimmunity against carbonic anhydrase II affects retinal cell functions in autoimmune retinopathy. J Autoimmun. 2009;32(2):133–9.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  83. Adamus G, Yang S, Weleber RG. Unique epitopes for carbonic anhydrase II autoantibodies related to autoimmune retinopathy and cancer-associated retinopathy. Exp Eye Res. 2016;147:161.

    Article  CAS  PubMed  Google Scholar 

  84. Adamus G, et al. Diversity in autoimmunity against retinal, neuronal, and axonal antigens in acquired neuro-retinopathy. J Ophthalmic Inflamm Infect. 2011;1(3):111–21.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  85. Radhakrishnan SS, et al. Patterns of visual function loss in autoimmune neuro-retinopathy (AINR): psychophysical and electrophysiological findings [ARVO abstract]. Invest Ophthalmol Vis Sci. 2010;51(5):E-abstract 3547.

    Google Scholar 

  86. Iyer SS, et al. Presentation of autoimmune neuro-retinopathy (AINR) patients with anti-carbonic anhydrase II auto-antibodies [ARVO Abstract]. Invest Ophthalmol Vis Sci. 2011;52(6):E-abstract 2924.

    Article  CAS  Google Scholar 

  87. Carboni G, et al. Bilateral paraneoplastic optic neuropathy and unilateral retinal compromise in association with prostate cancer: a differential diagnostic challenge in a patient with unexplained visual loss. Doc Ophthalmol. 2012;125:63.

    Article  PubMed  PubMed Central  Google Scholar 

  88. Epstein RS, et al. Clinical, functional, and imaging characteristics of cancer-associated retinopathy and optic neuropathy. In: American Academy of Ophthalmology meeting. 2014: Chicago, 18–22 Oct 2014.

    Google Scholar 

  89. Grange L, et al. Autoimmune retinopathy. Am J Ophthalmol. 2014;157(2):266–272 e1.

    Article  CAS  PubMed  Google Scholar 

  90. Comlekoglu DU, Thompson IA, Sen HN. Autoimmune retinopathy. Curr Opin Ophthalmol. 2013;24(6):598–605.

    Article  PubMed  Google Scholar 

  91. Ferreyra HA, et al. Management of autoimmune retinopathies with immunosuppression. Arch Ophthalmol. 2009;127(4):390–7.

    Article  CAS  PubMed  Google Scholar 

  92. Turaka K, et al. Carcinoma-associated retinopathy in a young teenager with immature teratoma of the ovary. J AAPOS. 2014;18(4):396–8.

    Article  PubMed  Google Scholar 

  93. Suhler EB, et al. Presumed teratoma-associated paraneoplastic retinopathy. Arch Ophthalmol. 2003;121(1):133–7.

    Article  PubMed  Google Scholar 

  94. Jacobson SG, et al. Interocular asymmetry of visual function in heterozygotes of X-linked retinitis pigmentosa. Exp Eye Res. 1989;48:679–91.

    Article  CAS  PubMed  Google Scholar 

  95. Ko AC, et al. Anti-gamma-enolase autoimmune retinopathy manifesting in early childhood. Arch Ophthalmol. 2010;128(12):1590–5.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  96. Polans AS, et al. Recoverin, a photoreceptor-specific calcium-binding protein, is expressed by the tumor of a patient with cancer-associated retinopathy. Proc Natl Acad Sci U S A. 1995;92(20):9176–80.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  97. Pratesi F, et al. Autoantibodies specific for alpha-enolase in systemic autoimmune disorders. J Rheumatol. 2000;27(1):109–15.

    CAS  PubMed  Google Scholar 

  98. Iannaccone A, et al. Autoimmunity in age-related macular degeneration: a possible role player in disease development and progression. Adv Exp Med Biol. 2012;723:11–6.

    Article  CAS  PubMed  Google Scholar 

  99. Iannaccone A, et al. Circulating autoantibodies in age-related macular degeneration recognize human macular tissue antigens implicated in autophagy, immunomodulation, and protection from oxidative stress and apoptosis. PLoS One. 2015;10(12):e0145323.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  100. Iannaccone A, et al. Retinal pigment epithelium and microglia express the CD5 antigen-like protein, a novel autoantigen in age-related macular degeneration. Exp Eye Res. 2017;155:64–74.

    Article  CAS  PubMed  Google Scholar 

  101. Chang PY, Yang CH, Yang CM. Cancer-associated retinopathy in a patient with hepatocellular carcinoma: case report and literature review. Retina. 2005;25(8):1093–6.

    Article  PubMed  Google Scholar 

  102. Andreasson S, Ponjavic V, Ehinger B. Full-field electroretinogram in a patient with cutaneous melanoma-associated retinopathy. Acta Ophthalmol (Copenh). 1993;71:487–90.

    Article  CAS  Google Scholar 

  103. Milam AH, et al. Autoantibodies against retinal bipolar cells in cutaneous melanoma-associated retinopathy. Invest Ophthalmol Vis Sci. 1993;34:91–100.

    CAS  PubMed  Google Scholar 

  104. Lei B, et al. Human melanoma-associated retinopathy (MAR) antibodies alter the retinal ON-response of the monkey ERG in vivo. Invest Ophthalmol Vis Sci. 2000;41(1):262–6.

    CAS  PubMed  Google Scholar 

  105. Potter MJ, et al. Autoantibodies to transducin in a patient with melanoma-associated retinopathy. Am J Ophthalmol. 2002;134(1):128–30.

    Article  PubMed  Google Scholar 

  106. Jacobson DM, Adamus G. Retinal anti-bipolar cell antibodies in a patient with paraneoplastic retinopathy and colon carcinoma. Am J Ophthalmol. 2001;131(6):806–8.

    Article  CAS  PubMed  Google Scholar 

  107. Birg A, et al. Spectral-domain optical coherence tomography (SD-OCT) findings in patients with autoimmune neuro-retinopathy (AINR). Invest Ophthalmol Vis Sci. 2011;52(5):–E-Abstract 3690.

    Google Scholar 

  108. Iannaccone A, et al. Optic nerve/retinal ganglion cell involvement in autoimmune retinopathies resulting in autoimmune neuroretinopathy. In: American Academy of Ophthalmology meeting. Chicago; 2014. p. PO547.

    Google Scholar 

  109. Frishman L, et al. ISCEV extended protocol for the photopic negative response (PhNR) of the full-field electroretinogram. Doc Ophthalmol. 2018;136(3):207–11.

    Article  PubMed  PubMed Central  Google Scholar 

  110. Majander A, et al. The pattern of retinal ganglion cell dysfunction in Leber hereditary optic neuropathy. Mitochondrion. 2017;36:138–49.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  111. Karanjia R, et al. The photopic negative response: an objective measure of retinal ganglion cell function in patients with Leber’s hereditary optic neuropathy. Invest Ophthalmol Vis Sci. 2017;58(6):BIO300–6.

    Article  PubMed  Google Scholar 

  112. Katagiri S, et al. Retinal structure and function in eyes with optic nerve hypoplasia. Sci Rep. 2017;7:42480.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  113. You Y, et al. Optic neuropathies: characteristic features and mechanisms of retinal ganglion cell loss. Rev Neurosci. 2013;24(3):301–21.

    Article  PubMed  Google Scholar 

  114. Machida S. Clinical applications of the photopic negative response to optic nerve and retinal diseases. J Ophthalmol. 2012;2012:397178.

    Article  PubMed  PubMed Central  Google Scholar 

  115. Boudreault K, et al. Efficacy of rituximab in non-paraneoplastic autoimmune retinopathy. Orphanet J Rare Dis. 2017;12(1):129.

    Article  PubMed  PubMed Central  Google Scholar 

  116. Forooghian F, MacDonald IM. Rituximab for the treatment of autoimmune retinopathy. Am J Ophthalmol. 2017;180:xv–xvi.

    Article  PubMed  Google Scholar 

  117. Davoudi S, et al. Outcomes in autoimmune retinopathy patients treated with rituximab. Am J Ophthalmol. 2017;180:124–32.

    Article  CAS  PubMed  Google Scholar 

  118. Maleki A, et al. Rituximab as a monotherapy or in combination therapy for the treatment of non-paraneoplastic autoimmune retinopathy. Clin Ophthalmol. 2017;11:377–85.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  119. Uludag G, et al. Electroretinographic improvement after rituximab therapy in a patient with autoimmune retinopathy. Am J Ophthalmol Case Rep. 2016;2:4–7.

    Article  PubMed  PubMed Central  Google Scholar 

  120. Fox A, et al. Rituximab treatment for nonparaneoplastic autoimmune retinopathy. Can J Ophthalmol. 2015;50(6):e101–4.

    Article  PubMed  Google Scholar 

  121. Finn AP, Keenan RT, Jaffe GJ. Reconstitution of the ellipsoid zone with tocilizumab in autoimmune retinopathy. Retin Cases Brief Rep. 2018.

    Google Scholar 

  122. Grewal DS, Jaffe GJ, Keenan RT. Sarilumab for recalcitrant cystoid macular edema in non-paraneoplastic autoimmune retinopathy. Retin Cases Brief Rep. 2019.

    Google Scholar 

  123. Jaffe GJ, et al. Adalimumab in patients with active noninfectious uveitis. N Engl J Med. 2016;375(10):932–43.

    Article  CAS  PubMed  Google Scholar 

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Iannaccone, A., Senatore, A., Kheir, W.J., Creel, D., Yu, M. (2019). Characteristics of Visual Electrophysiology in Inflammatory Disorders. In: Yu, M., Creel, D., Iannaccone, A. (eds) Handbook of Clinical Electrophysiology of Vision. Springer, Cham. https://doi.org/10.1007/978-3-030-30417-1_8

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