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Tocilizumab for the treatment of birdshot uveitis that failed interferon alpha and anti-tumor necrosis factor-alpha therapy: two cases report and literature review

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Abstract

Biotherapies appear as potential drugs for the treatment of inflammatory noninfectious uveitis. In this report, we show that tocilizumab, an anti-IL-6 agent, greatly improved two patients with birdshot chorioretinopathy refractory to conventional immunosuppressive drugs, interferon α2a, and anti-TNFα agents. After a follow-up of 22 months, patients exhibited an improvement of both visual acuity and macular edema. A corticosteroid-sparing effect was achieved in both cases.

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Authors and Affiliations

  1. Normandie Université UNI Rouen, Service de Médecine Interne, CHU Charles Nicolle, 76000, Rouen, France

    Mathilde Leclercq & N. Girszyn

  2. Normandie Université UNI Rouen U1096, Service de Médecine Interne, CHU Charles Nicolle, 76000, Rouen, France

    M. Le Besnerais, Y. Benhamou & H. Levesque

  3. Service de Médecine Interne et Maladies Infectieuses, CH Le Havre, 76290, Montivilliers, France

    V. Langlois

  4. Normandie Université UNI Rouen, Service d’Ophtalmologie, CHU Charles Nicolle, 76000, Rouen, France

    C. Ngo, M. Muraine & J. Gueudry

Authors
  1. Mathilde Leclercq
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  2. M. Le Besnerais
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  3. V. Langlois
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  4. N. Girszyn
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  5. Y. Benhamou
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  6. C. Ngo
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  7. H. Levesque
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  8. M. Muraine
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  9. J. Gueudry
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Correspondence to Mathilde Leclercq.

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Leclercq, M., Le Besnerais, M., Langlois, V. et al. Tocilizumab for the treatment of birdshot uveitis that failed interferon alpha and anti-tumor necrosis factor-alpha therapy: two cases report and literature review. Clin Rheumatol 37, 849–853 (2018). https://doi.org/10.1007/s10067-018-4007-4

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  • DOI: https://doi.org/10.1007/s10067-018-4007-4

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