REBOA-Induced Ischemia-Reperfusion Injury

  • Jigarkumar A. Patel
  • Joseph M. WhiteEmail author
Part of the Hot Topics in Acute Care Surgery and Trauma book series (HTACST)


Resuscitative endovascular balloon occlusion of the aorta (REBOA)-induced ischemia-reperfusion injury (IRI) represents a complex pathophysiologic process involving dysfunction of intracellular and extracellular components responsible for metabolic, thrombotic, and inflammatory signaling and cellular function. Mitigation strategies following repair and re-establishment of end-organ perfusion include surgical and pharmacologic considerations and adjuncts. Currently, there is a paucity of clinical data concerning the incidence and associated clinical ramifications of IRI following REBOA deployment. Given this limitation, this chapter aims to review IRI as a result of REBOA and discuss the current literature on REBOA-associated IRI mitigation strategies.


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© Springer Nature Switzerland AG 2020

Authors and Affiliations

  1. 1.The Department of Surgery, Walter Reed National Military Medical CenterUniformed Services University of the Health SciencesBethesdaUSA

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