Abstract
A kinetic model for Excitatory Amino Acid Transporters (EAATs) was derived to analyze data from patch clamp experiments. The model was fitted to experimental data for EAAT1, and reliable parameter estimations were obtained. This allowed for inference and estimate of the turnover rate of EAAT1 and, potentially, for other EAATs, which would resolve longstanding discrepancies in the literature.
The authors thank Anastassios Tzingounis for data on Excitatory Amino Acid Transporter currents.
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Shchepakin, D., Kalachev, L., Kavanaugh, M. (2019). Modeling of Excitatory Amino Acid Transporters. In: Korobeinikov, A., Caubergh, M., Lázaro, T., Sardanyés, J. (eds) Extended Abstracts Spring 2018. Trends in Mathematics(), vol 11. Birkhäuser, Cham. https://doi.org/10.1007/978-3-030-25261-8_31
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DOI: https://doi.org/10.1007/978-3-030-25261-8_31
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