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Short- and Long-Term ICU-Acquired Immunosuppression

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Post-Intensive Care Syndrome

Part of the book series: Lessons from the ICU ((LEICU))

Abstract

Acute severe injuries such as sepsis, trauma, severe hemorrhage, major surgery or cardiac arrest account for most of the ICU admission. Thanks to advances in life support tools and knowledge, to technical progress, a majority of patients now survive the first days of their injury but are then exposed to the development of ICU-acquired infections that are associated with significant morbidity and mortality [1, 2]. The increasing burden of nosocomial infections and the emergence of multidrug resistant bacteria call to urgent progress in preventive treatment of ICU-acquired infections. Although the prolonged use of invasive medical devices and the selection of resistant bacteria remain important determinants of ICU-acquired infections, there is increasing evidence that some acquired immune dysfunctions might contribute to the increased susceptibility to secondary infections despite recovery from the primary insult.

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Authors and Affiliations

  1. Department of Intensive Care, CUB-Erasme, Université Libre de Bruxelles (ULB), Brussels, Belgium

    D. Grimaldi

  2. Service de Médecine Intensive – Réanimation, hôpital Cochin, Hôpitaux Universitaires Paris Centre, Assistance Publique – Hôpitaux de Paris, Paris, France

    F. Pène

  3. Faculté de Médecine, Université Paris Descartes, Paris, France

    F. Pène

  4. Institut Cochin, INSERM U1016, CNRS UMR8104, Paris, France

    F. Pène

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  1. D. Grimaldi
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Correspondence to F. Pène .

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Editors and Affiliations

  1. Department of Intensive Care, Erasme Hospital, Université libre de Bruxelles, Brussels, Belgium

    Jean-Charles Preiser

  2. Respiratory and CCM, Toronto General Hospital, University of Toronto, Toronto, ON, Canada

    Margaret Herridge

  3. Medical Intensive Care Unit, AP-HP Saint-Louis Hospital, Paris, France

    Elie Azoulay

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Grimaldi, D., Pène, F. (2020). Short- and Long-Term ICU-Acquired Immunosuppression. In: Preiser, JC., Herridge, M., Azoulay, E. (eds) Post-Intensive Care Syndrome. Lessons from the ICU. Springer, Cham. https://doi.org/10.1007/978-3-030-24250-3_11

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