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Heat Shock Protein 60 (HSP60): Role in Skeletal Muscle Diseases and Novel Prospects for Therapy

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Heat Shock Protein 60 in Human Diseases and Disorders

Part of the book series: Heat Shock Proteins ((HESP,volume 18))

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Abstract

Eukaryotic Hsp60 is also known as mitochondrial chaperones (Chaperonin, Cpn60) as earlier it was considered to be present in mitochondria only. Last few years it has become clear that it is also present in cytosol, cell surface, extracellular space and in the peripheral blood. Hsp60 plays a vital role in quality control of proteins. It interacts with Hsp10 (resides in mitochondria, also named as Cpn10) to prepare native conformational protein from nascent polypeptides in the presence of ATP. Some other newly identified functions of Hsp60 include cell survival and proliferation. Hsp60 has significant role in various skeletal muscle wasting diseases like sarcopenia, cancer cachexia, sepsis, denervation, burns, and chronic obstructive pulmonary disease. The present chapter describes a brief representative research efforts aimed to establish the role of Hsp60 in various skeletal muscle wasting conditions with the purpose to illustrate possible protective and therapeutic implications for developing novel approach to rectify them.

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Abbreviations

HSBP1:

Heat shock protein binding factor 1

HSEs:

Heat shock elements

HSF1:

Heat shock factor transcription factor

HSP:

Heat shock family

Hsp:

Heat shock proteins

Hsp60:

Heat shock protein60

IGF1:

Insulin growth factor-1

LMF:

Lipid mobilising factor

MAPK:

Mitogen-activated protein kinase

mTOR:

Mammalian target of rapamycin

TLRs:

Toll like receptors

UPS:

Unfolded protein response

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Acknowledgements

The authors are thankful to Dr. Bhuvnesh Kumar, Director, DIPAS, for his constant support and encouragement. The study was supported by the Defence Research and Development Organisation, Ministry of Defence, Government of India.

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  1. Cellular Biochemistry Group, Defense Institute of Physiology and Allied Sciences, Delhi, India

    Richa Rathor, Geetha Suryakumar, Som Nath Singh & Bhuvnesh Kumar

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Correspondence to Richa Rathor .

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Editors and Affiliations

  1. Department of Medicine and Director, Precision Therapeutics Proteogenomics Diagnostic Center, Eleanor N. Dana Cancer Center, University of Toledo, College of Medicine and Life Sciences, Toledo, OH, USA

    Alexzander A. A. Asea

  2. Department of Experimental Radiation Oncology, MD Anderson Cancer Center, Houston, TX, USA

    Punit Kaur

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Rathor, R., Suryakumar, G., Singh, S.N., Kumar, B. (2019). Heat Shock Protein 60 (HSP60): Role in Skeletal Muscle Diseases and Novel Prospects for Therapy. In: Asea, A., Kaur, P. (eds) Heat Shock Protein 60 in Human Diseases and Disorders. Heat Shock Proteins, vol 18. Springer, Cham. https://doi.org/10.1007/978-3-030-23154-5_18

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