Abstract
The eventual purpose of animal biotechnology is using the animals and animal cells to improve human health through nutrition, novel recombinant therapeutics and producing organs for transplantation. Utilizing the curative potential of microbiota is another motive of the pursuit of biotechnology into animal gut ecosystem.
Highlights
-
Human–animal interaction is associated with health and well-being
-
Various livestock species are important agriculturally and relevant as model organisms
-
Transgenic animals produce recombinant drugs, vaccines, and monoclonal antibodies.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
An L, Yang L, Huang Y, Cheng Y, Du F (2019) Generating goat mammary gland bioreactors for producing recombinant proteins by gene targeting. Methods Mol Biol 1874:391–401. https://doi.org/10.1007/978-1-4939-8831-0_23
Chan JL, Singh AK, Corcoran PC, Thomas ML, Lewis BG, Ayares DL, Vaught T, Horvath KA, Mohiuddin MM (2017) Encouraging experience using multi-transgenic xenografts in a pig-to-baboon cardiac xenotransplantation model. Xenotransplantation 24(6). https://doi.org/10.1111/xen.12330 (Epub 2017 Sep 22)
Chen W, Wang F, Tian C, Wang Y, Xu S, Wang R, Hou K, Zhao P, Yu L, Lu Z, Xia Q. (2018) Transgenic silkworm-based silk gland bioreactor for large scale production of bioactive human platelet-derived growth factor (pdgf-bb) in silk cocoons. Int J Mol Sci 19(9). pii: E2533. https://doi.org/10.3390/ijms19092533
Chung HJ, Park HJ, Baek SY, Park JK, Lee WY, Kim KW, Jo YM, Hochi S, Kim YM, Choi TJ, Cho ES, Cho KH (2018) Production of human tissue-type plasminogen activator (htPA) using in vitro cultured transgenic pig mammary gland cells. Anim Biotechnol 1–6. https://doi.org/10.1080/10495398.2018.1521824
Cooper DKC, Gaston R, Eckhoff D, Ladowski J, Yamamoto T, Wang L, Iwase H, Hara H, Tector M, Tector AJ (2018) Xenotransplantation-the current status and prospects. Br Med Bull 125(1):5–14. https://doi.org/10.1093/bmb/ldx043
Denner J (2017) Paving the path toward porcine organs for transplantation. N Engl J Med 377(19):1891–1893. https://doi.org/10.1056/NEJMcibr1710853 (No abstract available)
Feng X, Cao S, Wang H, Meng C, Li J, Jiang J, Qian Y, Su L, He Q, Zhang Q (2015) Production of transgenic dairy goat expressing human α-lactalbumin by somatic cell nuclear transfer. Transgenic Res 24(1):73–85. https://doi.org/10.1007/s11248-014-9818-8 (Epub 2014 Aug 20)
Finger EB, Bischof JC (2018) Cryopreservation by vitrification: a promising approach for transplant organ banking. Curr Opin Organ Transplant 23(3):353–360. https://doi.org/10.1097/MOT.0000000000000534
Friedman E, Krause-Parello CA (2018) Companion animals and human health: benefits, challenges, and the road ahead for human-animal interaction. Rev Sci Tech 37(1):71–82. https://doi.org/10.20506/rst.37.1.2741
Garcia-Gutierrez E, Mayer MJ, Cotter PD, Narbad A (2019) Gut microbiota as a source of novel antimicrobials. Gut Microbes 10(1):1–21. https://doi.org/10.1080/19490976.2018.1455790 (Epub 2018 May 22)
Gupta S (2017) Puppy power. Nature 543:S48–S49
He Z, Lu R, Zhang T, Jiang L, Zhou M, Wu D, Cheng Y (2018) A novel recombinant human plasminogen activator: efficient expression and hereditary stability in transgenic goats and in vitro thrombolytic bioactivity in the milk of transgenic goats. PLoS ONE 13(8):e0201788. https://doi.org/10.1371/journal.pone.0201788 (eCollection 2018)
Hryhorowicz M, Zeyland J, Słomski R, Lipiński D (2017) Genetically modified pigs as organ donors for xenotransplantation. Mol Biotechnol 59(9–10):435–444. https://doi.org/10.1007/s12033-017-0024-9 (Review)
Kim GA, Lee EM, Cho B, Alam Z, Kim SJ, Lee S, Oh HJ, Hwang JI, Ahn C, Lee BC (2019) Generation by somatic cell nuclear transfer of GGTA1 knockout pigs expressing soluble human TNFRI-Fc and human HO-1. Transgenic Res 28(1):91–102. https://doi.org/10.1007/s11248-018-0103-0 (Epub 2018 Dec 14)
Kishore GM, Shewmaker C (1999) Biotechnology: enhancing human nutrition in developing and developed worlds. Proc Natl Acad Sci U S A 96(11):5968–5972
Kumar M, Nagpal R, Verma V, Kumar A, Kaur N, Hemalatha R, Gautam SK, Singh B. (2013) Probiotic metabolites as epigenetic targets in the prevention of colon cancer. Nutr Rev 71(1):23–34. https://doi.org/10.1111/j.1753-4887.2012.00542.x (Epub 2012 Nov 9. Review)
Kwon DJ, Kim DH, Hwang IS, Kim DE, Kim HJ, Kim JS, Lee K, Im GS, Lee JW, Hwang S (2017) Generation of α-1,3-galactosyltransferase knocked-out transgenic cloned pigs with knocked-in five human genes. Transgenic Res 26(1):153–163. https://doi.org/10.1007/s11248-016-9979-8
Li Z, Quan G, Jiang X, Yang Y, Ding X, Zhang D, Wang X, Hardwidge PR, Ren W, Zhu G (2018) Effects of metabolites derived from gut microbiota and hosts on pathogens. Front Cell Infect Microbiol 8:314. https://doi.org/10.3389/fcimb.2018.00314 (eCollection 2018. Review)
Luo Y, Wang Y, Liu J, Lan H, Shao M, Yu Y, Quan F, Zhang Y (2015) Production of transgenic cattle highly expressing human serum albumin in milk by phiC31 integrase-mediated gene delivery. Transgenic Res 24(5):875–883. https://doi.org/10.1007/s11248-015-9898-0 (Epub 2015 Jul 22)
Mamo G (2016) Anaerobes as sources of bioactive compounds and health promoting tools. Adv Biochem Eng Biotechnol 156:433–464 (Review)
Menchaca A, Anegon I, Whitelaw CB, Baldassarre H, Crispo M (2016) New insights and current tools for genetically engineered (GE) sheep and goats. Theriogenology 86(1):160–169. https://doi.org/10.1016/j.theriogenology.2016.04.028
Monzani PS, Adona PR, Ohashi OM, Meirelles FV, Wheeler MB (2016) Transgenic bovine as bioreactors: challenges and perspectives. Bioengineered 7(3):123–131. https://doi.org/10.1080/21655979.2016.1171429 (Epub 2016 May 11)
Palmiter RD, Brinster RL, Hammer RE, Trumbauer ME, Rosenfeld MG, Birnberg NC, Evans RM (1982) Dramatic growth of mice that develop from eggs microinjected with metallothionein-growth hormone fusion genes. Nature 300:611–615
Pan D, Liu T, Lei T, Zhu H, Wang Y, Deng S (2019) Progress in multiple genetically modified minipigs for xenotransplantation in China. Xenotransplantation 26(1):e12492. https://doi.org/10.1111/xen.12492 (Review)
Parc AL, Karav S, Rouquié C, Maga EA, Bunyatratchata A, Barile D (2017) Characterization of recombinant human lactoferrin N-glycans expressed in the milk of transgenic cows. PLoS ONE 12(2):e0171477. https://doi.org/10.1371/journal.pone.0171477 (eCollection 2017)
Petersen B (2018) Transgenic pigs to the rescue. Elife 7. pii: e37641. https://doi.org/10.7554/elife.37641
Qian Q, You Z, Ye L, Che J, Wang Y, Wang S, Zhong B (2018) High-efficiency production of human serum albumin in the posterior silk glands of transgenicsilkworms, Bombyx mori L. PLoS ONE 13(1):e0191507. https://doi.org/10.1371/journal.pone.0191507 (eCollection 2018)
Sheridan C (2016) FDA approves ‘farmaceutical’ drug from transgenic chickens. Nat Biotechnol 34(2):117–119. https://doi.org/10.1038/nbt0216-117
Smood B, Hara H, Cleveland D, Cooper DKC (2019) In search of the ideal valve: optimizing genetic modifications to prevent bioprosthetic degeneration. Ann Thorac Surg. pii: S0003-4975(19)30251-6. https://doi.org/10.1016/j.athoracsur.2019.01.054 (Epub ahead of print Review)
Wang Y, Ding F, Wang T, Liu W, Lindquist S, Hernell O, Wang J, Li J, Li L, Zhao Y, Dai Y, Li N (2017) Purification and characterization of recombinant human bile salt-stimulated lipase expressed in milk of transgenic cloned cows. PLoS ONE 12(5):e0176864
Woodfint RM, Hamlin E, Lee K (2018) Avian bioreactor systems: a review. Mol Biotechnol 60(12):975–983. https://doi.org/10.1007/s12033-018-0128-x
Wu X, Ouyang H, Duan B, Pang D, Zhang L, Yuan T, Xue L, Ni D, Cheng L, Dong S, Wei Z, Li L, Yu M, Sun QY, Chen DY, Lai L, Dai Y, Li GP (2012) Production of cloned transgenic cow expressing omega-3 fatty acids. Transgenic Res 21(3):537–543. https://doi.org/10.1007/s11248-011-9554-2 (Epub 2011 Sep 15)
Xie Z, Pang D, Yuan H, Jiao H, Lu C, Wang K, Yang Q, Li M, Chen X, Yu T, Chen X, Dai Z, Peng Y, Tang X, Li Z, Wang T, Guo H, Li L, Tu C, Lai L, Ouyang H (2018) Genetically modified pigs are protected from classical swine fever virus. PLoS Pathog 14(12):e1007193. https://doi.org/10.1371/journal.ppat.1007193 (eCollection 2018 Dec)
Zhang R, Tang C, Guo H, Tang B, Hou S, Zhao L, Wang J, Ding F, Zhao J, Wang H, Chen Z, Dai Y, Li N (2018a) A novel glycosylated anti-CD20 monoclonal antibody from transgenic cattle. Sci Rep 8(1):13208. https://doi.org/10.1038/s41598-018-31417-2
Zhang X, Li Z, Yang H, Liu D, Cai G, Li G, Mo J, Wang D, Zhong C, Wang H, Sun Y, Shi J, Zheng E, Meng F, Zhang M, He X, Zhou R, Zhang J, Huang M, Zhang R, Li N, Fan M, Yang J, Wu Z (2018b) Novel transgenic pigs with enhanced growth and reduced environmental impact. Elife 7. pii: e34286. https://doi.org/10.7554/elife.34286
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
Copyright information
© 2019 Springer Nature Switzerland AG
About this chapter
Cite this chapter
Singh, B., Mal, G., Gautam, S.K., Mukesh, M. (2019). Animal Biotechnology in Human Health. In: Advances in Animal Biotechnology. Springer, Cham. https://doi.org/10.1007/978-3-030-21309-1_37
Download citation
DOI: https://doi.org/10.1007/978-3-030-21309-1_37
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-030-21308-4
Online ISBN: 978-3-030-21309-1
eBook Packages: Biomedical and Life SciencesBiomedical and Life Sciences (R0)