T-Cell Development: From T-Lineage Specification to Intrathymic Maturation

  • Kogulan Yoganathan
  • Edward L. Y. Chen
  • Jastaranpreet Singh
  • Juan Carlos Zúñiga-PflückerEmail author


T-cell development occurs in the thymus in both mice and humans. Upon entry into the thymus, bone marrow-derived blood-borne progenitors receive instructive signals, including Notch signaling, to extinguish their potential to develop into alternative immune lineages while committing to the T-cell fate. Upon T-lineage commitment, developing T-cells receive further instructional cues to generate different T-cell sublineages, which together possess diverse immunological functions to provide host immunity. Over the years, numerous studies have contributed to a greater understanding of key thymic signals that govern T-cell differentiation and subset generation. Here, we review these critical signaling factors that govern the different stages of both mouse and human T-cell development, while also focusing on the transcriptional changes that mediate T-cell identity and diversity.


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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Kogulan Yoganathan
    • 1
  • Edward L. Y. Chen
    • 1
  • Jastaranpreet Singh
    • 1
  • Juan Carlos Zúñiga-Pflücker
    • 1
    Email author
  1. 1.Department of Immunology, Sunnybrook Research InstituteUniversity of TorontoTorontoCanada

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