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Risk Alleles for Drug Targets: Genomic Markers of Drug Response

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Biomarkers in Inflammatory Bowel Diseases

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Abstract

The armamentarium for the treatment of inflammatory bowel disease (IBD) is growing with the introduction of new targeted therapies. Developing precision medicine approaches using our knowledge of IBD genetics is of great interest and importance. To date, research on genomic markers of drug response has largely focused on anti-tumor necrosis factor alpha (TNF) agents. Currently, no genetic markers have been validated for use in clinical practice to guide treatment selection. However, several studies have highlighted promising blood- and tissue-based markers of drug response. In this chapter, we provide an overview of the current evidence for genomic markers of response to biologics and discuss potential future directions for predictive biomarker discovery.

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Author information

Authors and Affiliations

  1. The Dr. Henry D. Janowitz Division of Gastroenterology, Icahn School of Medicine at Mount Sinai, New York, NY, USA

    Ryan Ungaro

  2. The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA

    Judy Cho

Authors
  1. Ryan Ungaro
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  2. Judy Cho
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Corresponding authors

Correspondence to Ryan Ungaro or Judy Cho .

Editor information

Editors and Affiliations

  1. St Vincent’s Hospital, The University of Melbourne, Melbourne, VIC, Australia

    Nik Sheng Ding

  2. Austin Health, The University of Melbourne, Melbourne, VIC, Australia

    Peter De Cruz

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Ungaro, R., Cho, J. (2019). Risk Alleles for Drug Targets: Genomic Markers of Drug Response. In: Sheng Ding, N., De Cruz, P. (eds) Biomarkers in Inflammatory Bowel Diseases. Springer, Cham. https://doi.org/10.1007/978-3-030-11446-6_28

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  • DOI: https://doi.org/10.1007/978-3-030-11446-6_28

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-11445-9

  • Online ISBN: 978-3-030-11446-6

  • eBook Packages: MedicineMedicine (R0)

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