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Functionalized Antibacterial Nanoparticles for Controlling Biofilm and Intracellular Infections

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Surface Modification of Nanoparticles for Targeted Drug Delivery

Abstract

The intracellular and biofilm associated bacterial infections are difficult to treat due to the resistance potential of the organisms toward commonly used antimicrobial agents. Nanoparticles have promising future in the development of new therapeutics because of their easy functionalization and unique mode of action. This book chapter consists of three parts. The first two parts explain the limitations in the treatment of intracellular and biofilm infections in the current scenario. The last part describes how nanoparticles can be employed to tackle the problems of drug resistance and the latest research studies conducted regarding the same.

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Acknowledgments

The authors are grateful to Centre for Nanosciences and Molecular Medicine, Amrita Institute of Medical Sciences and Research Centre, Amrita Vishwa Vidyapeetham, Kochi, 682041, India for infrastructural support and Nanomission grant (SR/NM/NT-1033/2016 G) from the Department of Science and Technology, India for financial support.

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  1. Centre for Nanosciences and Molecular Medicine, Amrita Institute of Medical Sciences and Research Centre, Amrita Vishwa Vidyapeetham, Kochi, Kerala, India

    Aparna Viswanathan, Jayakumar Rangasamy & Raja Biswas

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  1. College of Pharmacy, University of South Florida, Tampa, FL, USA

    Yashwant V Pathak

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Viswanathan, A., Rangasamy, J., Biswas, R. (2019). Functionalized Antibacterial Nanoparticles for Controlling Biofilm and Intracellular Infections. In: Pathak, Y. (eds) Surface Modification of Nanoparticles for Targeted Drug Delivery. Springer, Cham. https://doi.org/10.1007/978-3-030-06115-9_10

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