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Endoplasmic Reticulum Stress Signalling During Development

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The Unfolded Protein Response in Cancer

Part of the book series: Cancer Drug Discovery and Development ((CDD&D))

Abstract

The unfolded protein response (UPR) is a complex homeostatic programme that balances the load of secretory protein synthesis with the folding capacity of the endoplasmic reticulum (ER). Although originally believed to function predominantly as a stress response pathway, growing evidence supports a role for the UPR in the regulation of development. The study of human diseases alongside work with transgenic mouse models has implicated the UPR in a wide range of developmental processes. This chapter examines the three distinct branches of the UPR and their importance during development.

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Authors and Affiliations

  1. Cambridge Institute for Medical Research (CIMR), University of Cambridge, Cambridge, UK

    Caia S. Dominicus, Vruti Patel, Joseph E. Chambers, Elke Malzer & Stefan J. Marciniak

  2. The Francis Crick Institute, London, UK

    Caia S. Dominicus

  3. University College London, London, UK

    Vruti Patel

  4. MRC Harwell Institute Oxfordshire, England, UK

    Elke Malzer

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    Robert Clarke

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Dominicus, C.S., Patel, V., Chambers, J.E., Malzer, E., Marciniak, S.J. (2019). Endoplasmic Reticulum Stress Signalling During Development. In: Clarke, R. (eds) The Unfolded Protein Response in Cancer. Cancer Drug Discovery and Development. Humana Press, Cham. https://doi.org/10.1007/978-3-030-05067-2_2

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