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Coordinate regulation of cell cycle and apoptosis during myogenesis

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Progress in Cell Cycle Research

Part of the book series: Progress in Cell Cycle Research ((PCCR))

Abstract

During myogenesis, precursor cells irreversibly withdraw from the cell cycle as they differentiate into mature myotubes. The state of myocyte differentiation also influences the propensity of these cells to undergo apoptosis. Proliferative precursor cells are far more susceptible to apoptotic cell death than are terminally differentiated myotubes. The upregulation of the cdk inhibitor p21 and the dephosphorylation of pRb are critical regulatory events that establish both the post-mitotic and apoptosis-resistant states. The coordinate regulation of cell proliferation and death provides the organism with a mechanism to control the deposition of muscle mass during embryonic development.

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Author information

Authors and Affiliations

  1. Division of Cardiovascular Research, St. Elizabeth’s Medical Center and Tufts University School of Medicine, 736 Cambridge St., Boston, MA, 02135, USA

    Kenneth Walsh

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  1. Kenneth Walsh
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Editors and Affiliations

  1. Centre National de la Recherche Scientifique, Roscoff, France

    Laurent Meijer  & Silvana Guidet  & 

  2. Centre National de la Recherche Scientifique, Université de Rennes I, Rennes, France

    Michel Philippe

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© 1997 Springer Science+Business Media New York

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Walsh, K. (1997). Coordinate regulation of cell cycle and apoptosis during myogenesis. In: Meijer, L., Guidet, S., Philippe, M. (eds) Progress in Cell Cycle Research. Progress in Cell Cycle Research. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-5371-7_5

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  • DOI: https://doi.org/10.1007/978-1-4615-5371-7_5

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-7451-0

  • Online ISBN: 978-1-4615-5371-7

  • eBook Packages: Springer Book Archive

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