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Pericyte Secretome

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Pericyte Biology - Novel Concepts

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1109))

Abstract

The role of pericytes seems to extend beyond their known function in angiogenesis, fibrosis and wound healing, blood-brain barrier maintenance, and blood flow regulation. More and more data are currently accumulating indicating that pericytes, uniquely positioned at the interface between blood and parenchyma, secrete a large plethora of different molecules in response to microenvironmental changes. Their secretome is tissue-specific and stimulus-specific and includes pro- and anti-inflammatory factors, growth factors, and extracellular matrix as well as microvesicles suggesting the important role of pericytes in the regulation of immune response and immune evasion of tumors. However, the angiogenic and trophic secretome of pericytes indicates that their secretome plays a role in physiological homeostasis but possibly also in disease progression or could be exploited for regenerative processes in the future. This book chapter summarizes the current data on the secretory properties of pericytes from different tissues in response to certain pathological stimuli such as inflammatory stimuli, hypoxia, high glucose, and others and thereby aims to provide insights into the possible role of pericytes in these conditions.

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Abbreviations

AD:

Alzheimer disease

AGE:

Advanced glycation end product

Ang:

Angiopoietin

BDNF:

Brain-derived neurotrophic factor

CCL:

Chemokine (C-C motif)

CD:

Cluster of differentiation

CMV:

Cytomegalovirus

COX-2:

Prostaglandin-endoperoxide synthase 2

CXCL:

Chemoattractants

EC:

Endothelial cells

EGF:

Endothelial growth factor

ENA:

Epithelial-derived neutrophil-activating peptide

FGF:

Fibroblast growth factor

G-CSF:

Granulocyte colony-stimulating factor

GDNF:

Glial cell-derived neurotrophic factor

GM-CSF:

Granulocyte-macrophage colony-stimulating factor

GROα/β/γ:

Growth-regulated protein alpha/beta/gamma

GUCY1B3:

Guanylate cyclase 1 soluble beta3

HB-EGF:

Heparin-binding EGF-like growth factor

HGF:

Hepatocyte growth factor

HIF-1α:

Hypoxia-inducible factor 1-alpha

HIV-1:

Human immunodeficiency virus type-1

HLA:

Human leukocyte antigen

HO-1:

Heme oxygenase-1

ICAM:

Intercellular adhesion molecule

IFN:

Interferon

IGFPB:

Insulin-like growth factor-binding protein

IL:

Interleukin

iNOS:

Induced nitric oxide synthase

IP-10:

Interferon gamma-induced protein 10

ITAC:

Interferon-inducible T-cell alpha chemoattractant

JE:

Japanese encephalitis

LIF:

Leukemia inhibitory factor

LPS:

Lipopolysaccharide

MCP-1:

Monocyte chemoattractant protein-1

MHC:

Major histocompatibility complex

MIF:

Macrophage migration inhibitory factor

MMP:

Matrix metalloproteinases

MVs:

Microvesicles

NGF:

Nerve growth factor

NK:

Natural killer

NO:

Nitric oxide

NOX4:

NADPH oxidase 4

NT3:

Neurotrophin 3

PDGF:

Platelet-derived growth factor

PGES:

Prostaglandin E synthase

PLGF:

Placental growth factor

RANTES:

Regulated on activation normal T-cell expressed and secreted

ROS:

Reactive oxygen species

SCF:

Stem cell factor

SDF-1:

Stromal cell-derived factor 1 alpha

SELE:

Selectin E

TARC:

Thymus- and activation-regulated chemokine

TGF:

Transforming growth factor

TNF:

Tumor necrosis factor

VCAM-1:

Vascular cell adhesion protein

VEGF:

Vascular endothelial growth factor

ZO1:

Zona occludens 1

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Authors and Affiliations

  1. Translational Neurology Group, Department of Clinical Sciences and Wallenberg Center for Molecular Medicine, Department of Neurology, Lund University, Lund, Sweden

    Abderahim Gaceb & Gesine Paul

  2. Skåne University Hospital, Lund, Sweden

    Gesine Paul

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  1. Abderahim Gaceb
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  2. Gesine Paul
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Correspondence to Gesine Paul .

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  1. Department of Radiology, Columbia University Medical Center, New York, NY, USA

    Alexander Birbrair

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Gaceb, A., Paul, G. (2018). Pericyte Secretome. In: Birbrair, A. (eds) Pericyte Biology - Novel Concepts. Advances in Experimental Medicine and Biology, vol 1109. Springer, Cham. https://doi.org/10.1007/978-3-030-02601-1_11

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