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A Panoramic View of the Immune Response to Trypanosoma cruzi Infection

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Chagas Disease

Part of the book series: Birkhäuser Advances in Infectious Diseases ((BAID))

Abstract

Chagas disease is a complex disorder in which the immunological response developed by the host plays a fundamental role, not only in the clearance of the parasite but also in the inflammatory status observed in specific affected tissues. Chagas disease has two phases, acute and chronic, the latter being established in those cases where treatment with currently available anti-parasitic drugs (nifurtimox and benznidazole) is either not applied or not effective. During the chronic phase, the disease may remain without any detectable symptoms for several decades or progress toward cardiac, digestive, neurological forms, or even a combination of these alterations. The immune response developed in all of these conditions is flowery and comprises humoral and cellular components; however the clearance of the parasite is incomplete due to the multiple mechanisms that T. cruzi deploys in order to perpetuate itself within the host.

Here, we make an extensive review of T. cruzi-host immune response interactions with special attention on human models, also referring to the particular clinical scenario of etiological treatment in Chagas disease.

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  1. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular (INGEBI-CONICET), Buenos Aires, Argentina

    Gonzalo R. Acevedo, Magali C. Girard & Karina A. Gómez

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  1. Servicio de Parasitología y Enfermedad de Chagas, Hospital de Niños “Ricardo Gutiérrez”, Buenos Aires, Argentina

    Jaime Marcelo Altcheh

  2. Servicio de Parasitología y Enfermedad de Chagas, Hospital de Niños “Ricardo Gutiérrez”, Buenos Aires, Argentina

    Hector Freilij

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Acevedo, G.R., Girard, M.C., Gómez, K.A. (2019). A Panoramic View of the Immune Response to Trypanosoma cruzi Infection. In: Altcheh, J., Freilij, H. (eds) Chagas Disease. Birkhäuser Advances in Infectious Diseases. Springer, Cham. https://doi.org/10.1007/978-3-030-00054-7_3

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