Chagas Disease

A Clinical Approach

  • Jaime Marcelo Altcheh
  • Hector Freilij

Part of the Birkhäuser Advances in Infectious Diseases book series (BAID)

Table of contents

  1. Front Matter
    Pages i-xii
  2. Overview

    1. Front Matter
      Pages 1-1
    2. Héctor Freilij
      Pages 3-22
  3. The Agent

    1. Front Matter
      Pages 23-23
    2. Catalina D. Alba Soto, Stella Maris González Cappa
      Pages 25-59
    3. Gonzalo R. Acevedo, Magali C. Girard, Karina A. Gómez
      Pages 61-88
  4. Epidemiology

    1. Front Matter
      Pages 89-89
    2. Roberto Chuit, Roberto Meiss, Roberto Salvatella
      Pages 91-109
    3. Julio Alonso-Padilla, María Jesús Pinazo, Joaquim Gascón
      Pages 111-123
    4. Melissa S. Nolan, Kyndall Dye-Braumuller, Eva Clark
      Pages 125-138
  5. Diagnosis

    1. Front Matter
      Pages 139-139
    2. Alejandro O. Luquetti, Alejandro G. Schijman
      Pages 141-158
  6. Clinical Aspects

    1. Front Matter
      Pages 159-159
    2. Guillermo Moscatelli, Samanta Moroni
      Pages 161-178
    3. Jaime Marcelo Altcheh
      Pages 179-198
    4. Ênio Chaves de Oliveira, Alexandre Barcelos Morais da Silveira, Alejandro O. Luquetti
      Pages 243-264
    5. Adelina R. Riarte, Marisa L. Fernandez, Claudia Salgueira, Javier Altclas
      Pages 265-296
  7. Treatment

    1. Front Matter
      Pages 297-297
    2. Julián Ernesto Nicolás Gulin
      Pages 313-321
    3. Elizabeth Ruiz-Lancheros, Eric Chatelain, Momar Ndao
      Pages 323-349 Open Access
  8. Back Matter
    Pages 351-356

About this book


Chagas disease is a potentially life threatening condition that was historically mainly endemic to Latin America. Over the last decade, however, the disease has spread to and is increasingly prevalent in other continents such as North America and Europe, with an estimated 7 million people infected worldwide. It is primarily transmitted by insect vectors that carry the parasite Trypanosoma cruzi, the disease agent. In areas where there is vector control and in non-endemic countries, it is mainly transmitted via congenital infection. Cardiac and gastrointestinal complications are common in untreated individuals.This book offers a comprehensive overview of Chagas disease, including its vectorial and congenital transmission, and molecular diagnosis, which is essential for screening, and developing and providing timely, effective anti-trypanosomal treatment. Written by experts working with infected patients on a daily basis, it discusses the pathogenesis of congenital, cardiac, gastrointestinal and oral Chagas disease, as well as its treatment and the pharmacological aspects of drug development in this area.

The chapter, ‘Chagas Disease Treatment Efficacy Biomarkers: Myths and Realities’ is available open access under a Creative Commons Attribution 4.0 International License via


Chagas Trypanosoma cruzi Molecular diagnosis Epidemiology Treatment Congenital infection

Editors and affiliations

  • Jaime Marcelo Altcheh
    • 1
  • Hector Freilij
    • 2
  1. 1.Servicio de Parasitología y Enfermedad de Chagas, Hospital de Niños “Ricardo Gutiérrez”Buenos AiresArgentina
  2. 2.Servicio de Parasitología y Enfermedad de Chagas, Hospital de Niños “Ricardo Gutiérrez”Buenos AiresArgentina

Bibliographic information