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Disseminated Intravascular Coagulation in Cardiac Surgery

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Principles of Pulmonary Protection in Heart Surgery

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Abstract

Disseminated intravascular coagulation (DIC) is a complex thrombohemorrhagic disease, secondary to an underlying clinical disease,1 producing both thrombosis and hemorrhage. It is initiated by a number of defined disorders and consists of the following components2: exposure of blood to procoagulants; formation of fibrin in the circulation; fibrinolysis; depletion of clotting factors; and end-organ damage. Systemic activation of coagulation in its most extreme form is known as DIC,3 which occurs in approximately 1% of hospital admissions.4

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Authors and Affiliations

  1. Division of Cardiovascular Medicine, Duke University Medical Center, Duke Clinical Research Institute, 3850, 2400 Pratt Street, Room 0311, Durham, NC, 27705, USA

    Renato Delascio Lopes

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  1. Leticia Sandre Vendrame
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  2. Helio Penna Guimaraes
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  3. Renato Delascio Lopes
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Correspondence to Renato Delascio Lopes .

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  1. Federal University of Sao Paulo, Sao Paulo, 04023900, Brazil

    Edmo Atique Gabriel

  2. University of Miami, 1611 N.W. 12th Avenue, Miami, 33136, Florida, USA

    Tomas Salerno

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Vendrame, L.S., Guimaraes, H.P., Lopes, R.D. (2010). Disseminated Intravascular Coagulation in Cardiac Surgery. In: Gabriel, E., Salerno, T. (eds) Principles of Pulmonary Protection in Heart Surgery. Springer, London. https://doi.org/10.1007/978-1-84996-308-4_20

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